Changing trends ofin vitroantimicrobial resistance patterns in blood isolates in a tertiary care hospital over a period of 4 years

Abstract

Our findings suggest that there is a definite increase in the multidrug resistant organisms. The data on the changing trends in antibiotic resistance, we believe is an important pillar in our efforts at improving infection control practices.

Antimicrobial Resistance Pattern among Community-Acquired Gram-Positive and Gram-Negative Bacterial Bloodstream Isolates in India

“…This co-resistance could be mediated due to thickened cell wall, changes in cellular metabolism, and enhanced cell wall turnover that could interfere with the antimicrobial action of glycopeptides. Also, in case of S. aureus isolates, vancomycin, teicoplanin and linezolid reported high antimicrobial activity of 96.3%, 100% and 100% respectively; a finding similar to other studies [4][5][6][7][8][9][10]. On the contrary, reduced susceptibility was reported by Dubey et al (vancomycin,44.9%; teicoplanin, 44.7%; linezolid, 76.6%) [5].…”

“…recorded high level resistance to most antimicrobials (>50%) tested; with 80.4% isolates exhibiting ciprofloxacin resistance, similar to that reported by Kapoor et al [11]. Among the glycopeptides, 12.1% isolates were resistant to vancomycin, a frequency similar to that reported by other Indian studies (12-16.9%) [10,12]. This increase in vancomycin resistance could be attributed to the vanA genotype or the acquisition of vanB mobile genetic determinant [13,14].…”

Surveillance of multidrug resistant uropathogenic bacteria in hospitalized patients in Indian

“…Apart from the promotion of UTI from fecal matter, it is more readily in females than that of in males [20,21] , catheter-associated UTIs in both males and females are rampant [22,23] . In an Iranian study, the average length hospitalization for symptomatic development of UTI was recoded as 9.96 days [23] ; but fewer days, i.e., 7 d were reported with the catheter-associated UTI development elsewhere [24] . In summary, the most frequently UTI pathogens could be arranged in the decreasing order, Klebsiella, E. coli, Pseudomonas and Enterobacter; not surprisingly the fungus Candida sp.…”

“…An aliquot of 5 mL of nitrite broth (peptone 5 g, beefextract 3 g, KNO 3 1 g and distilled water 1 000 mL) was inoculated with 1 drop of 24 h old broth test culture and was incubated for 48 h at 37 °C . From the development of red colour within 30 seconds of adding a few drops of the reagent A (α-napthol 5 g in 1 000 mL of 30% acetic acid) and reagent B (sulphanilic acid 5 g in 1 000 mL acetic acid), the positive result was inferred.…”

Microbiological Profile and Antibiogram of Blood Stream Isolates at a Referral Hospital in North Delhi: A One Year Study

“…Besides helping in treatment of the patient, profile of the isolated organisms provides useful adjuncts to choice of empiric therapy in a given set up. Comparison of the etiological profile of our blood cultures with various studies has been done in Table 1 [1,[7][8][9][10][11][12][13][14][15][16][17][18][19][20]. We observed in our study, maximum number of isolates was Coagulase negative Staphylococcus (40.5%).Similar findings have been reported by other authors -41.2% by Lu et al [7], 42% by Karlosky et al [8]and 54.3% by Bharmare et al [13].…”