Changing trends in clinicopathological parameters in dengue with evaluation of predictors of poor outcome in children

Ramachandran, Smita; Gera, Akriti; Kamal, Murtaza; Gera, Rani; Roy, Manas Pratim

doi:10.18203/2349-3291.ijcp20163688

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…However, the bleeding manifestations described in the present study were considerably lower compared to previous Sri Lankan studies. Table 5 [29][30][31][32][33][34][35][36][37][38][39][40][41] compared the findings of our study with similar studies from South Asia. The distribution of gender was comparable.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka

Jayarajah

Madarasinghe²,

Hapugoda³

et al. 2020

Global Pediatric Health

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Introduction: Analyzing dengue disease patterns from different parts of the world should help us formulate more evidence based treatment guidelines and appropriately allocate limited healthcare resources. Therefore, we described the disease characteristics of hospitalised pediatric patients with dengue infections from Sri Lanka during the 2017 dengue epidemic. Methods: Clinical and biochemical characteristics of pediatric dengue patients treated at a secondary care hospital in Sri Lanka from 1 June 2017 to 31 August 2017 were analyzed. Our findings were compared with previous pediatric dengue studies in Asia. Results: A total of 305 patients (number of males = 184(60%); mean age = 8.6 years) were analyzed. DF (Dengue Fever)—245 (80.3%), DHF (Dengue Hemorrhagic fever)—I:52 (17%), DHF—II:7 (2.3%), and DHF—III:1 (0.3%). Significant associations were found between DHF and abdominal symptoms/signs and overt bleeding manifestations ( P < .001). Time of onset of the critical phase was variable (Day 3: 12%, Day 4-5: 78%, Day 6: 5%, and Day 7: 5%). Platelet and white-cell counts (WBC) were significantly lower in DHF than DF; liver enzyme derangement was mild and was similar in the DHF and DF subgroups. None had cardiac, renal, or neurological manifestations and all recovered uneventfully. Conclusion: In Sri Lankan pediatric dengue patients, we found abdominal symptoms and signs, decreased WBC and platelet counts and bleeding manifestations were to be significantly associated with DHF. Liver enzyme derangement did not predict DHF. The time of onset of the critical phase was difficult to predict due to the considerable variations noted.

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Section: Discussionmentioning

confidence: 99%

Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka

Jayarajah

Madarasinghe²,

Hapugoda³

et al. 2020

Global Pediatric Health

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“…16 The clinical features in our study ranged from the usual triad of fever, vomiting, and abdominal pain to rare condition such as association with West syndrome; similar features have been documented in other Indian studies. 13,17,18 When we compared severe dengue cases with other cases, there was no significant difference in clinical presentation except the fact that myalgia was less common in the severe form of the disease. Hematemesis and melena were most frequent bleeding manifestation.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Biochemical Findings in Confirmed Pediatric Dengue Cases in Delhi

Agarwal

Roy

Singh

2017

J Pediatr Infect Dis

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The clinical presentations of dengue fever range from mild viral fever to life-threatening manifestations that may be typical or atypical. With the World Health Organization recommending new guidelines for the diagnosis of dengue, it becomes necessary to document clinical spectrum for classification and setting priorities. Therefore, a study was undertaken to document clinical and biochemical profile and outcome in dengue-positive pediatric patients. Records were retrieved from August to November 2015 in a tertiary care hospital in Delhi. Out of 188 dengue-positive patients enrolled, 61.1% were males. Mortality rate was 1%. Apart from the classic triad of fever, vomiting and abdominal pain, there were some atypical presentations, including febrile seizure (5.8%) and acute respiratory distress syndrome (3%). Myalgia was rare in the severe form of the disease. On laboratory investigation, anemia (75%) and thrombocytopenia (73%) were most common findings. Platelet counts were significantly lower in severe dengue than in other types.

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“…Asites, efusi pleura, dan hemokonsentrasi merupakan faktor risiko atau prediktor bermakna syok dengue. 4,7,21,26,27 Infeksi dengue sekunder dialami 40,4% subyek SSD. Hal ini mungkin terjadi karena peran antibodydependent enhancement dalam patogenesis SSD.…”

Section: Pembahasanunclassified

Faktor Prognosis Sindrom Syok Dengue pada Anak

Satari¹,

Mardani²,

Gunardi³

2018

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Latar belakang. Manifestasi klinis yang bervariasi, patogenesis yang kompleks, dan perbedaan serotipe virus membuat sulit memprediksi perjalanan penyakit dengue. Banyak penelitian yang telah dilakukan tentang faktor prognosis terjadinya sindrom syok dengue (SSD), tetapi semuanya menggunakan pedoman World Health Organization (WHO) tahun 1997. Tujuan. Penelitian ini bertujuan mengetahui faktor-faktor prognosis terjadinya SSD berdasarkan pedoman WHO tahun 2011.Metode. Studi retrospektif menggunakan data rekam medik pasien anak usia 0 sampai <18 tahun dengan diagnosis demam berdarah dengue (DBD), SSD dan expanded dengue syndrome (EDS) yang memenuhi kriteria WHO tahun 2011 di RSCM dari Januari 2013 sampai Desember 2016. Variabel independen, yaitu jenis kelamin, usia, status gizi, infeksi dengue sekunder, leukopenia, nyeri abdomen, perdarahan gastrointestinal, hepatomegali dan kebocoran plasma. Syok merupakan variabel dependen. Analisis multivariat menggunakan analisis regresi logistik. Hasil. Subyek yang memenuhi kriteria penelitian 145 pasien, 52 (35,8%) di antaranya mengalami SSD. Lima dari 52 pasien SSD mengalami syok selama perawatan di rumah sakit. Analisis bivariat yang menghasilkan faktor-faktor signifikan di antaranya, malnutrisi, gizi lebih dan obesitas, perdarahan gastrointestinal, hemokonsentrasi, asites, leukosit ≥5.000 mm3, ensefalopati, peningkatan enzim hati dan overload. Hasil analisis multivariat menunjukkan variabel hemokonsentrasi dan peningkatan enzim hati merupakan faktor prognosis SSD. Kesimpulan. Hemokonsentrasi dan peningkatan enzim hati merupakan faktor prognosis terjadinya SSD.

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Changing trends in clinicopathological parameters in dengue with evaluation of predictors of poor outcome in children

Cited by 7 publications

References 9 publications

Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka

Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka

Clinical and Biochemical Findings in Confirmed Pediatric Dengue Cases in Delhi

Faktor Prognosis Sindrom Syok Dengue pada Anak

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