Changing Susceptibility of <i>Staphylococcus aureus</i> in a US Pediatric Population

Sutter, Deena E.; Milburn, Emma; Chukwuma, Uzo; Dzialowy, Nicole; Maranich, Ashley M.; Hospenthal, Duane R.

doi:10.1542/peds.2015-3099

Cited by 119 publications

(116 citation statements)

References 38 publications

(59 reference statements)

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“…Rates of MRSA are lower in northern California compared with other parts of the United States. 36 At KPNC only 10% of pediatric S aureus bacteremia cases are due to MRSA. Our N meningitidis bacteremia rates of 0.2 per 100 000 children are consistent with the national estimate of 0.3 per 100 000 children.…”

Section: Figurementioning

confidence: 99%

Bacteremia in Children 3 to 36 Months Old After Introduction of Conjugated Pneumococcal Vaccines

2017

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BACKGROUND AND OBJECTIVES: In June 2010, Kaiser Permanente Northern California replaced all 7-valent pneumococcal conjugate vaccine (PCV7) vaccines with the 13-valent pneumococcal conjugate vaccine (PCV13). Our objectives were to compare the incidence of bacteremia in children 3 to 36 months old by 3 time periods: pre-PCV7, post-PCV7/pre-PCV13, and post-PCV13. METHODS: We designed a retrospective review of the electronic medical records of all blood cultures collected on children 3 to 36 months old at Kaiser Permanente Northern California from September 1, 1998 to August 31, 2014 in outpatient clinics, in emergency departments, and in the first 24 hours of hospitalization. RESULTS: During the study period, 57 733 blood cultures were collected in the population of children 3 to 36 months old. Implementation of routine immunization with the pneumococcal conjugate vaccine resulted in a 95.3% reduction of Streptococcus pneumoniae bacteremia, decreasing from 74.5 to 10 to 3.5 per 100 000 children per year by the post-PCV13 period. As pneumococcal rates decreased, Escherichia coli, Salmonella spp, and Staphylococcus aureus caused 77% of bacteremia. Seventy-six percent of all bacteremia in the post-PCV13 period occurred with a source. CONCLUSIONS: In the United States, routine immunizations have made bacteremia in the previously healthy toddler a rare event. As the incidence of pneumococcal bacteremia has decreased, E coli, Salmonella spp, and S aureus have increased in relative importance. New guidelines are needed to approach the previously healthy febrile toddler in the outpatient setting.

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Section: Figurementioning

confidence: 99%

Bacteremia in Children 3 to 36 Months Old After Introduction of Conjugated Pneumococcal Vaccines

2017

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“…Antibacterial prophylaxis in the presence of TMP-SMX intolerance is difficult, because few oral agents with reliable activity against both S aureus (including methicillin-resistant strains, especially while the rates of clindamycin resistance are rising progressively [9]) and Gram-negative pathogens are available. The first step of antibacterial prophylaxis in a patient with CGD and an apparent sulfa allergy is determining whether true hypersensitivity in fact exists, because antibiotic allergy rates are often overreported.…”

Section: Prophylactic Antibiotic Therapymentioning

confidence: 99%

Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease

Slack

Thomsen

2018

Journal of the Pediatric Infectious Diseases Society

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Chronic granulomatous disease (CGD) is a primary immunodeficiency that confers a markedly increased risk of bacterial and fungal infections caused by certain opportunistic pathogens. Current evidence supports the use of prophylactic antibacterial, antifungal, and immunomodulatory therapies designed to prevent serious or life-threatening infections in patients with CGD. In this review, we discuss current strategies for the prevention of infections in children and adults with CGD and the evidence that supports those strategies. In addition, we address current challenges and opportunities for future research in this important area.

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“…9 Recent surveillance reports of S aureus infections in children in the United States have indicated that the percentage of CA-MRSA isolates among S aureus-causing community infections has plateaued and that the incidence of health care-associated invasive MRSA infections has declined. 10,11 In the study by Sutter et al, 1 isolates recovered from outpatients and inpatients were grouped together, and thus no distinctions were made for infections that were CA, health care associated but with community onset, or hospital acquired. The most common site of infection was skin and soft tissue, but the second most common site was "other" infections, which were not further identified.…”

Section: Section Of Infectious Diseases Department Of Pediatrics Bamentioning

confidence: 99%

“…In this issue of Pediatrics, Sutter et al 1 report the antibiotic susceptibility trends of Staphylococcus aureus isolates recovered from >39 000 children who received care at sites within the US military health system from 2005 through 2014. S aureus is the most common pathogen causing skin and soft tissue infections (SSTIs) as well as some invasive infections such as osteomyelitis and septic arthritis in children.…”

mentioning

confidence: 99%

Staphylococcus aureus Infections in Children: The Implications of Changing Trends

Kaplan

2016

Pediatrics

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Changing Susceptibility of Staphylococcus aureus in a US Pediatric Population

Cited by 119 publications

References 38 publications

Bacteremia in Children 3 to 36 Months Old After Introduction of Conjugated Pneumococcal Vaccines

Bacteremia in Children 3 to 36 Months Old After Introduction of Conjugated Pneumococcal Vaccines

Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease

Staphylococcus aureus Infections in Children: The Implications of Changing Trends

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