Changing species distribution and antimicrobial susceptibility pattern ofShigellaover a 29-year period (1980–2008)

Khatun, Fatema; Faruque, A. S. G.; Koeck, Jean-Louis; Olliaro, Piero; Millet, Patrick; Paris, Nancy; Malek, Mohammad Abdul; Salam, Mohammed Abdus; Luby, Stephen P.

doi:10.1017/s0950268810001093

Cited by 42 publications

(41 citation statements)

References 17 publications

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“…No isolates of S. boydii and S. dysenteriae were identified. These results are in keeping with reports of previous studies in which S. flexneri was responsible for more than 50z of shigellosis cases (34)(35)(36).…”

Section: Discussionsupporting

confidence: 93%

Prevalence and Virulence Genes of Shigella spp. Isolated from Patients with Diarrhea in Rosario, Argentina

et al. 2016

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SUMMARY:The aim of this study was to determine the prevalence and virulence factors of Shigella species isolated from patients with diarrhea. Shigella species were isolated from 1,022 stool samples collected from different hospitals in Rosario, Argentina. The isolates were characterized using phenotypic tests, serotyping, and detection of virulence genes by PCR. One hundred strains (9.8z of samples collected) of Shigella were isolated. Shigella flexneri was the most frequently identified species (74z), followed by S. sonnei (26z). S. flexneri was also the predominant species isolated from children aged 6-14 years. These clinical strains of Shigella were then tested for the presence of ipaH, virA, ial, sen, and set using specific primers. virA was present in all strains, whereas ipaH was detected in 98z of strains and ial in 83z. sen was found in 71.6z of S. flexneri and 42.3z of S. sonnei isolates, and 41.9z of S. flexneri isolates were positive for set. Furthermore, 32.4z of S. flexneri isolates were positive for both set and sen. This study provides data on the prevalence and distribution of diverse Shigella strains.

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Section: Discussionsupporting

confidence: 93%

Prevalence and Virulence Genes of Shigella spp. Isolated from Patients with Diarrhea in Rosario, Argentina

et al. 2016

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“…Shigella was the second most isolated organism in Mirzapur, but was significantly lower in the other sites, especially Mirpur. A 2011 study conducted with 83,073 patients in Dhaka, revealed that the proportion of hospitalized patients with Shigella decreased steadily from 8% to 12% in 1980 to 3% in 2008 [32]. Our results also indicate that S. flexneri is the dominant circulating species; this finding supports reports previously indicating the dominance of S. flexneri in Bangladesh [32].…”

Section: Discussionsupporting

confidence: 88%

“…A 2011 study conducted with 83,073 patients in Dhaka, revealed that the proportion of hospitalized patients with Shigella decreased steadily from 8% to 12% in 1980 to 3% in 2008 [32]. Our results also indicate that S. flexneri is the dominant circulating species; this finding supports reports previously indicating the dominance of S. flexneri in Bangladesh [32]. The results from the study also illustrate that V. cholerae continues to be a major [33,34,35].…”

Section: Discussionsupporting

confidence: 87%

Etiological diversity of diarrhoeal disease in Bangladesh

Das

Ahmed

Ferdous

et al. 2013

J Infect Dev Ctries

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Background: This study compared the diversity of common diarrhoeal pathogens and antimicrobial susceptibility in four hospitals in Bangladesh. Methodology: A total of 13,959 diarrhoea patients, comprising rural Mirzapur [2,820), rural Matlab (2,865), urban Dhaka (5,287) and urban Mirpur (2,987) were included under the diarrhoeal disease surveillance system of icddr,b during 2010-2011; stool specimens were tested for Shigella spp., Vibrio cholerae, enterotoxigenic Escherichia coli and rotavirus. Results: Rotavirus was highest in Mirzapur (28%) followed by Dhaka (24%), Matlab (19%) and Mirpur (18%). Overall, Shigella was significantly more prevalent in rural sites (Mirzapur 13% and Matlab 7%), than in urban sites (Dhaka 3% and Mirpur 3%). Vibrio cholerae was more common in the urban sites of Dhaka (14%) and Mirpur (12%). 72% of Shigella isolates were susceptible to ciprofloxacin in Mirzapur, and 88% to mecillinam. In Dhaka, the figures for Shigella were 65% and 50%, in Matlab 65% and 85%, and in Mirpur 59% and 92% respectively. Susceptibility of Shigella to azithromycin and ceftriaxone in Dhaka was 74% and 95%, and in Mirpur 88% and 92% respectively. Vibrio cholerae showed the highest resistance to trimethoprim-sulfamethoxazole (100% in Mirpur) and lowest resistance to ciprofloxacin (0% in Dhaka, Matlab and Mirpur) and azithromycin (30% in Dhaka to 7% in Mirzapur). Multidrug resistance (≥ 3 antibiotics) for Shigella were: Mirzapur (50%); Dhaka (36%); Matlab (23%) and Mirpur (37%); and for V. cholerae it was 26%, 37%, 49% and 23% respectively. Conclusion: The isolation rates and antimicrobial susceptibility of Shigella spp. and V. cholerae along with rotavirus differed significantly in certain geographical sites.

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“…Previously efficacious antibiotics have become ineffective in treatment of the diseases due to emergence of multidrug resistance Shigella [13][14][15]. Consequently, the need for a safe and effective Shigella vaccine becomes more pressing and WHO has assigned a high priority to the development of vaccine against shigellosis [16,17].…”

Section: Introductionmentioning

confidence: 99%

Whole genome analysis to detect potential vaccine-induced changes on Shigella sonnei genome

Behar

Fookes

Goren

et al. 2015

Vaccine

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Changing species distribution and antimicrobial susceptibility pattern ofShigellaover a 29-year period (1980–2008)

Cited by 42 publications

References 17 publications

Prevalence and Virulence Genes of <i>Shigella</i> spp. Isolated from Patients with Diarrhea in Rosario, Argentina

Prevalence and Virulence Genes of <i>Shigella</i> spp. Isolated from Patients with Diarrhea in Rosario, Argentina

Etiological diversity of diarrhoeal disease in Bangladesh

Whole genome analysis to detect potential vaccine-induced changes on Shigella sonnei genome

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