Changing patterns of infection in cancer patients

Glucan-induced modification of the increased susceptibility of cyclophosphamide-treated mice to Staphylococcus aureus infection

“…Infectious episodes are one of the leading causes of morbidity and mortality in patients who are immunosuppressed due to malignancy or chemotherapy (Hughes, 1971(Hughes, , 1977Gaya et al, 1973;Ladisch and Pizzo, 1978). Staphylococcus aureus is one of the grampositive organisms commonly associated with septicemia in the immunodeficient host (Hughes, 1971;Ladisch and Pizzo, 1978).…”

IMMUNOCHEMOTHERAPY WITH CORYNEBACTERIUM PARVUM IN DISSEMINATED CANCER*

“…This finding has also been reported by Adlam et aL27 and Halpern ef aL2* This is a very important point when one considers the role of infection in cancer mortality. 29 With regard to immunocompetence, effective chemotherapy can lead to the reappearance of an adequate immune status by reducing tumor volume. Chemotherapy, however, induces quantitative immune depression, the very type that can be countered by immunopotentiators.…”

Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis

“…Severe infections frequently occur in patients with hemoproliferative malignancies (5,13,15,18,19). They may be difficult to cure, as antimicrobial agents which are effective in normal hosts appear to have lost, at least in part, their efficacy in these patients.…”

“…(B) Rectal temperature of five rats during infection (normal temperature, 37.4 + 0.340C). The following determinations were made after sacrificing15 rats in groups of 5. (C) Weight of the left lobe of the lung (normal weight, 0.6 ± 0.15 g).…”