Changing pattern of dengue virus serotypes circulating during 2008–2012 and reappearance of dengue serotype 3 may cause outbreak in Kolkata, India

Abstract

Dengue virus infection is a major cause of morbidity within the endemic tropical and subtropical regions of the world. Dengue virus has four distinct serotypes with specific clinical manifestations. In this study, we observed the changing pattern of dengue serotypes, age-wise dengue infection and useful sero-detection methods needed in a dengue endemic region. We identified dengue serotypes during a period of 5 years among patients with dengue symptoms visiting one of the largest tertiary care infectious disease hospitals of eastern India in Kolkata. A total of 433 dengue RNA positive samples were isolated from 712 acute dengue suspected cases. Age wise distribution highlighted the susceptible age group being >21 years (24.02%) followed by 11-15 years (21.71%) and 5-10 years (21.02%) of the total infected population. Higher numbers of infected cases were found within females as they are involved in more indoor works. The period of study experienced two dengue outbreaks one in 2008 and another in 2012. For early dengue detection, NS1 was found to be more confirmatory than IgM ELISA regarding sensitivity and specificity. DENV-1, 2, and 4 serotypes were the common circulating strains from 2008 until 2010, after which DENV-3 serotype infections rise and led to a massive dengue outbreak in Kolkata with increased numbers of DHF and DSS cases in 2012. The finding within our study emphasizes the public health importance of such prospective surveillance programs with respect to the changing dengue viral etiology and serotypes. J. Med. Virol. 88:1697-1702, 2016. © 2016 Wiley Periodicals, Inc.

Dengue hemophagocytic syndrome: A systematic review and meta‐analysis on epidemiology, clinical signs, outcomes, and risk factors

“…According to previous articles, 48 to 2012. 50 In Puerto Rico, 87.0% of the reported cases were identified during 2012 to 2013, the DENV-1 was dominant in that period. 26 These findings suggest that the dominance of dengue virus serotypes in India and Puerto Rico may be associated with the clear difference of the reported cases between DENV-1 and DENV-2 identified in this systematic review and meta-analysis.…”

“…The dominant prevalence of DENV‐1 was shown in two countries with the largest number of cases India and Puerto Rico compared with DENV‐2. In India, 77.8% of the reported cases were confirmed during 2011 to 2012, the DENV‐1 was dominant followed by DENV‐3 during 2008 to 2012 . In Puerto Rico, 87.0% of the reported cases were identified during 2012 to 2013, the DENV‐1 was dominant in that period .…”

Study of serum VEGF levels in patients with severe dengue infection admitted in a tertiary care hospital in Kolkata

“…Over the past two decades, India has experienced a dramatic increase in the frequency of dengue cases. More precisely, in states like Kerala, Delhi, and West Bengal, the situation has worsened after the Dengue‐3 serotype introduction . As per the 2016 WHO guideline, the clinical manifestation of dengue fever varies from a nonspecific febrile illness to vomiting and fluid accumulation.…”

“…Delhi, and West Bengal, the situation has worsened after the Dengue-3 serotype introduction. 4 As per the 2016 WHO guideline, the clinical manifestation of dengue fever varies from a nonspecific febrile illness to vomiting and fluid accumulation. Restless state, lethargy, and rapid decline in the number of platelets were classified in dengue with warning signs (DWWS), while vasodilatation and fluid accumulation in the lung with respiratory difficulty and continuous bleeding was classified in severe dengue (SD).…”

Cosmopolitan A1 lineage of dengue virus serotype 2 is circulating in Pakistan: A study from 2017 dengue viral outbreak

“…Numerous studies have already described the relationship between DENV serotypes, genotypes and/or lineages, and clinical outcome severity as well as their epidemic potential. Research was conducted in multiple areas to study shifts in serotype and lineage or clade of circulating dengue virus which caused more severe dengue epidemics . A study by Watt et al linked American genotype of DENV2 with less severe infections.…”