Changing mortality and causes of death in infants 23-27 weeks' gestational age

Doyle, Lex W.; Gultom, Elisabeth Margareth; Chuang, Shu-Ling; James, Matthew T.; Davis, Peter G; Bowman, Ellen

doi:10.1046/j.1440-1754.1999.00349.x

Cited by 43 publications

(24 citation statements)

References 6 publications

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“…In the present study, the outcome was better in patients with gestational age above 30 weeks and this was statistically significant (p = 0.035). Outcome according to birth weight was also better amongst patients with birth weight greater than 2000 g. Other studies corroborate this finding to this fact [27] [28] [29]. The mortality was quite high in our study 27 (28.4%) …”

Section: Discussionsupporting

confidence: 90%

Risk Factors and Outcome of Preterm Admissions in a Special Care Baby Unit of a Tertiary Hospital in North Central Nigeria

Ochoga¹,

Michael²,

Abah³

et al. 2018

OJPed

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The main objective of this study was to determine the prevalence of preterm births, risk factors and the outcome in a Tertiary Hospital in North Central Nigeria. Setting and Methods: The study was based on the data of records of all preterm admissions over a three-year period at Benue State University Teaching Hospital (BSUTH), Makurdi, Benue State. Results: During this period, a total of 778 neonates were admitted out of which 95 (12.0%) were preterm with gestational ages ranging from 21 -36 weeks with an average mean gestational age 31.27 weeks (±3.2) and birth weights from 500 -2490 g with a mean of 1440 g (±0.45). There were 48 males and 47 females (M: F 1.02). 76 (80.0%) were delivered by spontaneous vaginal delivery while 19 (20.0%) were delivered by caesarean section. 37 (39.0%) were delivered in BSUTH while 58 (61.0%) were delivered elsewhere and referred or brought into Special Care Baby Unit (SCBU). The duration of hospital stay ranged from 1 -90 days, with a mean duration of 17 days (±15.2 days). The commonest risk factor for prematurity was premature rupture of membrane followed by multiple pregnancy and lack of Ante natal care (ANC). The commonest morbidity in the patients in the present study was sepsis followed by respiratory problems and jaundice. Of the 95 preterm, 60 (63.2%) were discharged, 27 (28.4%) died, while 8 (8.4%) were discharged against medical advice (DAMA). Conclusion: Prematurity remains a major cause of morbidity and mortality in our SCBU. There is urgent need for the establishment of a neonatal intensive care unit with adequate manpower and appropriate equipment so as to improve the survival rates of this vulnerable group of patients.

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Section: Discussionsupporting

confidence: 90%

Risk Factors and Outcome of Preterm Admissions in a Special Care Baby Unit of a Tertiary Hospital in North Central Nigeria

Ochoga¹,

Michael²,

Abah³

et al. 2018

OJPed

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“…Circulatory failure is responsible for a high proportion of neonatal mortality,2 particularly when associated with sepsis, and is implicated in the pathogenesis of neonatal cerebral3 and pulmonary injury 4…”

mentioning

confidence: 99%

Functional cardiac MRI in preterm and term newborns

Groves

Chiesa

Durighel

et al. 2010

Archives of Disease in Childhood - Fetal and Neonatal Edition

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ObjectiveTo use cardiac MRI techniques to assess ventricular function and systemic perfusion in preterm and term newborns, to compare techniques to echocardiographic methods, and to obtain initial reference data.DesignObservational magnetic resonance and echocardiographic imaging study.SettingNeonatal Unit, Queen Charlotte's and Chelsea Hospital, London, UK.Patients108 newborn infants with median birth weight 1627 (580–4140) g, gestation 32 (25–42) weeks.ResultsMean (SD) flow volumes assessed by phase contrast (PC) imaging in 28 stable infants were left ventricular output (LVO) 222 (46), right ventricular output (RVO) 219 (47), superior vena cava (SVC) 95 (27) and descending aorta (DAo) 126 (32) ml/kg/min, with flow being higher at lower gestational age. Limits of agreement for repeated PC assessment of flow were LVO ±50.2, RVO ±55.5, SVC ±20.9 and DAo ±26.2 ml/kg/min. Mean (SD) LVO in 75 stable infants from three-dimensional models were 245 (47) ml/kg/min, with limits of agreement ±58.3 ml/kg/min. Limits of agreement for repeated echocardiographic assessment of LVO were ±108.9 ml/kg/min.ConclusionsDetailed magnetic resonance assessments of cardiac function and systemic perfusion are feasible in newborn infants, and provide more complete data with greater reproducibility than existing echocardiographic methods. Functional cardiac MRI could prove to be a useful research technique to study small numbers of newborn infants in specialist centres; providing insights into the pathophysiology of circulatory failure; acting as an outcome measure in clinical trials of inotropic intervention and so guiding clinical practice in the wider neonatal community.

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“…In addition, surfactant could be inactivated by oxygen radicals and enzymes. 16,[18][19][20] Further study is needed to evaluate the efficacy of administering surfactant to neonates who experience secondary respiratory failure after recuperation from their initial respiratory distress.…”

Section: Discussionmentioning

confidence: 99%

Treatment of acute respiratory distress syndrome in secondary surfactant deficiency in neonates

Samudro¹,

Winarno²

2007

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Changing mortality and causes of death in infants 23-27 weeks' gestational age

Cited by 43 publications

References 6 publications

Risk Factors and Outcome of Preterm Admissions in a Special Care Baby Unit of a Tertiary Hospital in North Central Nigeria

Risk Factors and Outcome of Preterm Admissions in a Special Care Baby Unit of a Tertiary Hospital in North Central Nigeria

Functional cardiac MRI in preterm and term newborns

Treatment of acute respiratory distress syndrome in secondary surfactant deficiency in neonates

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