Changing molecular epidemiology of hepatitis C virus infection in Northeast Italy

Molin, G. Dal; Ansaldi, Filippo; Biagi, C.; D’Agaro, Pierlanfranco; Comar, Manola; Crocè, Lory Saveria; Tiribelli, Claudio; Campello, Cesare

doi:10.1002/jmv.10210

Cited by 58 publications

(57 citation statements)

References 23 publications

(24 reference statements)

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“…The distributions were similar for Subtypes 1a (53.1% versus 51.5%), 3a (25% versus 37.9%) in patients and donors respectively. Subtypes 1a and 3a most often infect injecting drug users and appear to be increasing in prevalence [18,19]. At present, injection drug use is the most common risk factor for contracting the infection.…”

Section: Discussionmentioning

confidence: 99%

Identification of HCV genotypes in HCV infected blood donors

Sharifi¹,

Shooshtari²,

Kermani³

2010

Indian J Microbiol

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HCV infection is a leading cause of chronic liver disease, including cirrhosis of the liver. There are at least six major genotypes and more than 50 subtypes of HCV. The prevalence and distribution of HCV genotypes depend on geographical location. The aim of this study was to identify and compare the HCV genotypes in HCV infected blood donors and patients. In this cross-sectional study, 167 serum samples from 103 blood donors and 64 patients with hepatitis C were investigated for HCV genotypes. HCV genotyping was carried out using type-specifi c primers from the core region of the viral genome. The highest frequency was for genotype 1a, with 53 and 34 (51.5% versus 53.1%) of subjects in blood donors and patients respectively. Genotype 3a and 1b were the other frequent genotypes with 4 and 16 (3.9% versus 25%) and 39 and 10 (37.9% versus 15.6%) subjects, respectively. There was not any statistical signifi cant association between the place of infection of the patients and genotype. The results of this study indicate that the distribution of genotypes in the two populations was similar. The dominant HCV genotypes between blood donors and patients were 1a, 3a and 1b respectively.

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Section: Discussionmentioning

confidence: 99%

Identification of HCV genotypes in HCV infected blood donors

Sharifi¹,

Shooshtari²,

Kermani³

2010

Indian J Microbiol

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“…HCV genotypes 1, 2 and 3 are commonly distributed all over the world and their relative prevalence varies from one geographic area to another, while genotypes 4, 5, and 6 are generally found only in certain areas. For example, HCV subtypes 1a and 1b are the most common genotypes in the United States (13), Europe (14)(15)(16)(17) and Japan (18). HCV-3 (predominantly 3a) is the most prevalent genotype circulating in India (19) and Pakistan (20).…”

Section: Introductionmentioning

confidence: 99%

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Zhang

Fan

Wang³

et al. 2012

Hepat Mon

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Background:The changing pattern of hepatitis C virus (HCV) infection could have a significant impact on future medical prevention practices and therapies. Objectives: The purpose of this study was to describe the changing pattern of HCV infection in southwest China using clinical epidemiology, and to assess the association between the genotypes distribution and certain potential risk factors. Patients and Methods: A retrospective analysis which included 1208 subjects with chronic HCV registered at the Southwest Hospital (Chongqing, Southwest China) was performed. The information was reviewed and the data collected from clinical records and short telephone interviews when necessary. HCV genotypes were determined by nucleotide sequencing of the CE1 regions followed by phylogenic analysis with the published HCV genotype. HCV genotype distribution was analyzed according to the patients' age, gender, risk exposure, and the initial risk exposure. Results: Among the 1 208 patients, the HCV subtype 1b was the most prevalent (32.9%), followed by subtype 3b (18.9%), 6a (18.0%), 3a (12.8%) and 2a (10.4%), while subtypes 1a and 6k accounted for cases of HCV infection in only 9 and 3 cases respectively. Individuals older than 40 years were mainly infected with subtypes 1b and 2a, whereas younger patients were predominantly infected with genotypes 3 and 6. Subtypes 1b and 2a were observed more frequently among 44.4% and 16.0% patients respectively, with a history of invasive operations. Subtypes 3b and 6a constituted the majority of HCV infections among intravenous drug users (IDUs) (28.7% and 34.9%, respectively). A significant difference (P < 0.001) was observed between the HCV genotype distributions, according to the potential route of infection. Conclusion: In southwest China, the most common remaining subtype is the 1b genotype, but this has declined significantly among young patients. This is followed by subtype 3b and 6a which has increased significantly, especially among young patients. The distribution of such genotypes was also variable according to gender and age. The changing pattern of HCV infection was associated with changes in the modes of HCV acquisition, which raises an alarm signal concerning the major steps that need to be taken in order to reduce such infections in southwest China.

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“…In Europe, there have been dynamic changes over time in the prevalence of the different HCV subtypes. For example, the prevalence of HCV 1b has decreased, while conversely, that of HCV 1a and 3a has increased (4,6,25,26). Some rare genotypes have recently emerged in the Western world.…”

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confidence: 99%

High Prevalence of Hepatitis C Virus Type 5 in Central France Evidenced by a Prospective Study from 1996 to 2002

et al. 2004

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From 1996 to 2002, hepatitis C virus (HCV) typing was prospectively performed for 1,281 unselected HCV-infected and viremic patients, irrespective of their clinical status. Eighty-three patients (6.5%) were coinfected with human immunodeficiency virus (HIV) and HCV. A total of 1,195 strains were identified by a serotype screening (Murex HCV Serotyping 1-6 assay) and/or genotyping (Inno-LiPA HCV II) test. The distribution of HCV types showed an unusually high rate of type 5 (14.2%) that was stable over time and was the third most frequent type, after type 1 (59.1%) and type 3 (15.1%). HCV type 5 was more frequent in patients who were older than 50 (P ‫؍‬ 10 ؊6 ), but its frequency did not differ significantly by gender (P ‫؍‬ 0.21). Serotyping was performed for 1,160 strains but failed for 30.2% of them. The efficiency depended on HIV status (for HCV-HIV-coinfected patients, half of the strains were untypeable) and HCV type. Genotyping was performed for 428 samples, with an overall efficiency of 99.3%. It failed in three cases, which were subsequently identified as HCV type 2. Serotyping and genotyping results for 39 patients showed discrepancies between the two methods for 4 patients, who had HCV type 2, type 6, or mixed infections. Thus, HCV type 5 may also be encountered frequently in Western countries. Its apparent confinement to a restricted area raises the question of how it emerged and underscores the need for further studies of HCV type prevalence, routes of transmission, pathogenicity, and responses to treatment.

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Changing molecular epidemiology of hepatitis C virus infection in Northeast Italy

Cited by 58 publications

References 23 publications

Identification of HCV genotypes in HCV infected blood donors

Identification of HCV genotypes in HCV infected blood donors

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

High Prevalence of Hepatitis C Virus Type 5 in Central France Evidenced by a Prospective Study from 1996 to 2002

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