Changing lanes: seasonal differences in cellular metabolism of adipocytes in grizzly bears (Ursus arctos horribilis)

Hutzenbiler, Brandon D. Evans; Robbins, Charles T.; Jansen, Heiko T.

doi:10.1007/s00360-021-01428-z

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…In support of this, HK expression was also downregulated in H H cells but not H G cells. This would be consistent with a general reduction in glycolysis previously reported (Jansen et al, 2019) and aerobic respiration observed in vitro (Hogan et al, 2022).…”

Section: Discussionsupporting

confidence: 93%

Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes

et al. 2022

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Section: Discussionsupporting

confidence: 93%

Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes

et al. 2022

Self Cite

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“…This is consistent with previous studies analyzing repeatabilities of energy metabolism in wild mammalian populations (Boratynski et al 2019 ; Labocha et al 2004 ; Larivee et al 2010 ; Nespolo and Franco 2007 ). However, it is well known that the capacity of fat accumulation is enhanced prior to hibernation in several species (Hogan et al 2022 ; Kokurewicz and Speakman 2006 ; Kortner and Heldmaier 1995 ) and has been particularly well studied in the Alpine marmot, which maximizes energy assimilation by selective feeding and enhancing gastrointestinal capacity (Ruf et al 2023 ). Thus, our results suggesting absence of inter-individual variation in fat accumulation capacity would be in contrast to this evidence and deserve further examination.…”

Section: Discussionmentioning

confidence: 99%

Modeling heterothermic fitness landscapes in a marsupial hibernator using changes in body composition

Abarzúa,

Camus,

Ortiz

et al. 2023

Oecologia

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Hibernation is an adaptive strategy that allows animals to enter a hypometabolic state, conserving energy and enhancing their fitness by surviving harsh environmental conditions. However, addressing the adaptive value of hibernation, at the individual level and in natural populations, has been challenging. Here, we applied a non-invasive technique, body composition analysis by quantitative magnetic resonance (qMR), to calculate energy savings by hibernation in a population of hibernating marsupials (Dromiciops gliroides). Using outdoor enclosures installed in a temperate rainforest, and measuring qMR periodically, we determined the amount of fat and lean mass consumed during a whole hibernation cycle. With this information, we estimated the daily energy expenditure of hibernation (DEEH) at the individual level and related to previous fat accumulation. Using model selection approaches and phenotypic selection analysis, we calculated linear (directional, β), quadratic (stabilizing or disruptive, γ) and correlational (ρ) coefficients for DEEH and fat accumulation. We found significant, negative directional selection for DEEH (βDEEH = − 0.58 ± 0.09), a positive value for fat accumulation (βFAT = 0.34 ± 0.07), and positive correlational selection between both traits (ρDEEH × FAT = 0.24 ± 0.07). Then, individuals maximizing previous fat accumulation and minimizing DEEH were promoted by selection, which is visualized by a bi-variate selection surface estimated by generalized additive models. At the comparative level, results fall within the isometric allometry known for hibernation metabolic rate in mammals. Thus, by a combination of a non-invasive technique for body composition analysis and semi-natural enclosures, we were characterized the heterothermic fitness landscape in a semi-natural population of hibernators.

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Circadian gene transcription plays a role in cellular metabolism in hibernating brown bears, Ursus arctos

Vincent,

Perry,

Kelley

et al. 2023

J Comp Physiol B

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Changing lanes: seasonal differences in cellular metabolism of adipocytes in grizzly bears (Ursus arctos horribilis)

Cited by 7 publications

References 52 publications

Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes

Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes

Modeling heterothermic fitness landscapes in a marsupial hibernator using changes in body composition

Circadian gene transcription plays a role in cellular metabolism in hibernating brown bears, Ursus arctos

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