Changing cytogenetic picture in an acute myeloproliferative disorder

Berry, Elizabeth W.; Desforges, Jane F.

doi:10.1016/0002-9343(69)90155-7

Cited by 9 publications

(2 citation statements)

References 12 publications

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“…At the same time it has been demonstrated that, if an abnormal stem line is established in a patient with AML, this clone will not be replaced by normal diploid cells at a later stage of the disease-unless there is a remission. Evolution of a new clone in an already cytogenetically abnormal bone marrow-as in case 3 of the present series-has been described in a few patients with AML (1,11).…”

Section: Discussionsupporting

confidence: 63%

Cytogenetic Studies in Acute Myeloid Leukaemia

Jensen

1971

Journal of Internal Medicine

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Abstract. Cytogenetic studies have been carried out on bone marrow aspirates from 50 patients with acute myeloid leukaemia (AML). Abnormal stem lines were present in 22 patients; the remainder had a diploid chromosome complement. In all patients the majority of the metaphases had a blurred appearance and in many of the bone marrow aspirates studied before therapy the blurred metaphases showed chromatid breaks. Several bone marrow aspirates were obtained from six patients with a diploid chromosome complement. In none of these was the emergence of an abnormal cell line seen. In seven patients abnormal stem lines were demonstrated before the diagnosis of AML could be made. Based on the present results and on a review of the relevant literature, some general cytogenetic features are emphasized which have contributed to a better understanding of the leu‐kaemic process. Finally, the significance of cytogenetic studies in the diagnosis and therapeutic handling of leukaemia is discussed.

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Section: Discussionsupporting

confidence: 63%

Cytogenetic Studies in Acute Myeloid Leukaemia

Jensen

1971

Journal of Internal Medicine

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“…Although chromosomal analyses have been performed in 32 patients with sideroblastic anemia [1,2,4,6,7,13,14,16,17,21,24], only 22 had IARSA according to the criteria defined by Kushner [18]: In five re ported patients with sideroblastic anemia, associated illnesses, drug expo sure, or malignancy were present [13]; one patient had chronic erythremic myelosis [2]; one had a congenital sideroblastic anemia [7]; and one had a pyridoxine-responsive sideroblastic anemia [13]. For two others, either no chromosomal data were available for analysis or the analysis had been performed only when overt leukemia developed [10,24].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Acquired Refractory Sideroblastic Anemia: Banded Chromosome Analysis in Six Patients

Bitran¹,

Golomb²,

Rowley³

1977

Acta Haematol

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Chromosome analyses with banding were performed on six patients with idiopathic acquired refractory sideroblastic anemia (IARSA). One patient was found to have an extra chromosome No. 8, but had a normal level of red cell glutathione reductase. Bone marrow chromosomes from the other patients showed a normal karyotype. 28 patients with IARSA, including our 6 patients, have had chromosomal analyses. Two consistent chromosomal abnormalities have been described: a + 8 in three patients and a 20q- in three others. Despite the presence of chromosomal abnormalities in about one half of the patients, no patient has yet developed acute myelogenous leukemia. Several have died of hemochromatosis. The presence of a chromosomal abnormality appears to have no influence on the early course of IARSA.

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Chromosomes and causation of human cancer and leukemia. XIII. An evaluation of karyotypic findings in erythroleukemia

Sakurai

Sandberg

1976

Cancer

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This study was a n attempt a t defining the cytogenetic features of erythroleu-kemia (EL), particularly as related to the group of AML patients with MAKA (major karyotypic abnormalities), which generally were caused by three or more cellular events of translocation or nondisjunction. Eight of the 17 patients with MAKA had a diagnosis of E L or possible EL. I n most cases, MAKA was featured by hypodiploidy, karyotypic instability, and polyploidy in the leu-kemic cells. The most common abnormalities were loss of B or G group chromosomes and gain of a #16 or one or more marker chromosomes. Each of the markers of 2q+, Dqf, mar(A2, st), mar(C12, M), r(?F) and minute metacentric and acentric markers was observed in two or more patients .The extent of polyploidy seemed to be correlated with the proportion of erythroid precursor cells i n the marrow and with the karyotypic instability. Since the patients exhibited the same chromosomal features, whether or not they h a d a diagnosis of E L or possible EL, a n d since patients without such a diagnosis also had cytologic suggestions of EL, a close relation of MAKA t o E L is assumed. I t is believed that patients with MAKA constitute one of the three chromosomally classifiable groups of EL. Cancer 37:79&504, 1976. NCERTAINTY CONTINUES TO EXIST AS TO

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Changing cytogenetic picture in an acute myeloproliferative disorder

Cited by 9 publications

References 12 publications

Cytogenetic Studies in Acute Myeloid Leukaemia

Cytogenetic Studies in Acute Myeloid Leukaemia

Idiopathic Acquired Refractory Sideroblastic Anemia: Banded Chromosome Analysis in Six Patients

Chromosomes and causation of human cancer and leukemia. XIII. An evaluation of karyotypic findings in erythroleukemia

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