Changing Composition of Renal Calculi in Patients with Musculoskeletal Anomalies

Gnessin, Ehud; Mandeville, Jessica A.; Handa, Shelly E.; Lingeman, James E.

doi:10.1089/end.2010.0698

Cited by 31 publications

(18 citation statements)

References 14 publications

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“…Thus, for example, after the first burst of dissolution, as a temporary equilibrium is established between the solid surface and the solution, DCP in contact with the body fluid is expected to form a layer of HAP on its surface, which would protect it from further dissolution [21–25]. Being the most stable CP phase at pH > 6.5 [26, 27], HAP is supposed to partially cede place to DCP as an in vivo precipitate only under pathological conditions, such as cariogenesis [28], dental calculus formation [29], corneal calcification [30], atherosclerosis [31], calcific arthritis [32], renal and urinary lithiasis [33], osteomyelitis [34], or aggressive osteoporosis [35], or in the zones of excessive osteoclastic activity [36]. Such circumstances are not uncommon, which explains why uncertainties regarding the fate of CP implants in the body are still tied to their use.…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Uskoković

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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BACKGROUND Does chemistry govern biology or it is the other way around - that is a broad connotation of the question that this study attempted to answer. METHOD Comparison was made between the solubility and osteoclastic resorbability of four fundamentally different monophasic CP powders with monodisperse particle size distributions: alkaline hydroxyapatite (HAP), acidic monetite (DCP), β-calcium pyrophosphate (CPP), and amorphous CP (ACP). RESULTS With the exception of CPP, the difference in solubility between different calcium phosphate (CP) phases became neither mitigated nor reversed, but augmented in the resorptive osteoclastic milieu. Thus, DCP, a phase with the highest solubility, was also resorbed more intensely than any other CP phase, whereas HAP, a phase with the lowest solubility, was resorbed least. CPP becomes retained inside the cells for the longest period of time, indicating hindered digestion of only this particular type of CP. Osteoclastogenesis was mildly hindered in the presence of HAP, ACP and DCP, but not in the presence of CPP. The most viable CP powder with respect to the mitochondrial succinic dehydrogenase activity was the one present in natural biological bone tissues: HAP. CONCLUSION Chemistry in this case does have a direct effect on biology. Biology neither overrides nor reverses the chemical propensities of inorganics with which it interacts, but rather augments and takes a direct advantage of them. SIGNIFICANCE These findings set the fundamental basis for designing the chemical makeup of CP and other biosoluble components of tissue engineering constructs for their most optimal resorption and tissue regeneration response.

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Section: Introductionmentioning

confidence: 99%

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Uskoković

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Percutaneous nephrostomy tubes and retrograde ureteral stents are generally equivalent in their capacity to resolve fever in patients with upper urinary tract obstruction, but given the patient's circumstances may dictate a preference for one access instead of the other. [15] In our patients with positive urine cultures E. coli was the most common organism, which accounted for 60.0% of the positive cultures. Escherichia coli is the most frequent aetiological agent in any UTI, whereas other gram-negative bacteria such as Klebsiella spp.…”

Section: Discussionmentioning

confidence: 62%

Comparison Between PCN Tube and Urethral Tube Urine Specimen Culture in Complicated Uti

Mishra¹,

Garg²,

Bharti³

et al. 2017

jemds

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BACKGROUNDThe PCN catheter urine culture is important in cases of complicated urinary tract infections, especially in obstructive uropathy. It is therapeutic as well as diagnostic. The aim of this study was to compare the results of urine cultures obtained either from urethral or percutaneous nephrostomy (PCN) catheters. MATERIALS AND METHODSThis study included 78 consecutive patients that underwent PCN at our institution with complicated urinary tract infections (UTIs) between July 2016 and June 2017. Results of urine cultures obtained from the urethral and nephrostomy catheters were compared. RESULTSThis study included 56 male and 22 female patients. Mean age of the patients was 15 -55 years. The main indications were obstructive uropathy due to urolithiasis and PUJO complicated with pyonephrosis 43 (55%), malignant disease (n= 20; 25%), pregnancy (n= 4; 5%) and others (n= 11; 15%); 13 patients had diabetes mellitus. The most common causative organisms were Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Blood cultures showed the same results for the PCN and bladder urine cultures. The urethral urine culture was positive in 71 patients, while the PCN urine culture in 76 patients. CONCLUSIONPCN is an important treatment for the management of pyonephrosis. Cultures from the PCN yield valuable information that is not available from urethral urine cultures and is a guiding tool for antibiotic therapy selection.

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“…The authors found only 37% to be struvite while 63% were metabolically derived [9]. A follow-up study from the same authors in 2011 reported stone analysis following PCNL was most commonly a metabolic stone, with calcium phosphate predominating [10]. Examining stone composition in our cases would have improved our analysis and likely furthered the point that many upper tract stones in this population could be prevented.…”

Section: Discussionmentioning

confidence: 71%

Development of upper tract stones in patients with congenital neurogenic bladder

Stephany

Clayton

Tanaka

et al. 2014

Journal of Pediatric Urology

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Objective Patients with neurogenic bladder are at increased risk of developing upper tract stones. We hypothesized that patients with lower urinary tract stone disease are at greater risk of developing upper tract stones. Methods We performed a 10-year retrospective case–control study of patients with neurogenic bladder to determine the association between bladder and upper tract stones. Independent risk factors for upper tract stones were assessed. Cases and controls were matched 1:1. Univariable analysis was performed by Fisher's exact test and the Mann–Whitney U test. Multivariable logistic regression was performed. Results 52 cases and controls were identified. Cases were significantly more likely to be non-ambulatory, have bowel–urinary tract interposition, thoracic level dysraphism, and history of bladder stones. On multivariable analysis, independent predictors of stone formation were male sex (OR 2.82; p = 0.02), dysraphism involving the thoracic spine (OR 3.37; p = 0.014) bowel–urinary tract interposition (OR 2.611; p = 0.038), and a history of bladder stones (OR 3.57; p = 0.015). Conclusion Patients with neurogenic bladder are at increased risk for upper tract stones. The presence of bladder stones may herald the development of upper tract stones. The predictors of stone disease identified should guide prospective studies to better understand the natural history of upper tract stone development in this population.

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Changing Composition of Renal Calculi in Patients with Musculoskeletal Anomalies

Abstract: Although patients with MS anomalies are traditionally thought to harbor infection-related calculi, most will be found to have calculi of metabolic etiology. The incidence of calcium phosphate stones is high in this group of patients, perhaps reflecting their high urinary pH.

Cited by 31 publications

References 14 publications

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Comparison Between PCN Tube and Urethral Tube Urine Specimen Culture in Complicated Uti

Development of upper tract stones in patients with congenital neurogenic bladder

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