Changes over Time in Hemoglobin A1C (HbA1C) Levels Predict Long-Term Survival Following Acute Myocardial Infarction among Patients with Diabetes Mellitus

Plakht, Ygal; Gilutz, Harel; Shiyovich, Arthur

doi:10.3390/jcm10153232

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…High levels of glycated haemoglobin lead to a reduction in the body's ability to compensate for hypoxia, which has an effect on the establishment of collateral circulation and consequently on the recovery of cardiac function. High levels of glycated haemoglobin trigger abnormalities in the body's endothelial function, making the atherosclerotic plaque less stable and increasing the incidence of untoward events [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Glycated Haemoglobin Level, Cardiac Function, and Prognosis in Patients with Diabetes Mellitus Combined with Myocardial Infarction

Zeng

An²,

Li³

et al. 2022

Disease Markers

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Objective. This study was to investigate the correlation between glycated haemoglobin (HbA1c) level, cardiac function, and prognosis in patients with diabetes mellitus combined with myocardial infarction. Methods. Ninety-three patients with type 2 diabetes mellitus combined with acute myocardial infarction who were hospitalized and treated in our hospital from January 2021 to June 2021 were recruited for prospective analysis and equally divided into group A ( HbA 1 c < 6.5 % ), group B ( 6.5 % ≤ HbA 1 c ≤ 8.5 % ), and group C ( HbA 1 c > 8.5 % ) using the random number table method, with 31 patients in each group. General data of patients were collected on admission and blood glucose and cardiac function indexes were measured; the incidence of myocardial infarction and death during the follow-up period was recorded at 6 months after discharge. Results. There was a significant difference in blood glucose (FBG) and HbA1c levels at fasting between the three groups ( P < 0.05 ). There were statistically significant differences in plasma levels of N-terminal probrain natriuretic peptide (NT-proBNP) and uric acid (UA), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic volume (LVESV), left ventricular ejection fraction (LVEF), and cardiac function classification of the New York Heart Association (NYHA) among the three groups ( P < 0.05 ). By statistical analysis, the HbA1c level was positively correlated with FBG, NT-proBNP, UA, LVEDD, LVESD, and NYHA grades but negatively correlated with LVEF ( P < 0.05 ). The incidence rate of myocardial infarction and mortality was significantly higher in group C than in groups A and B ( P < 0.05 ). Conclusion. HbA1c level in patients with diabetes mellitus combined with myocardial infarction is closely related to the degree of cardiac function damage. Glycated haemoglobin levels are associated with the development of cardiac insufficiency in patients with acute myocardial infarction; glycated haemoglobin is also an independent predictor of major adverse cardiovascular events. Reasonable and effective blood glucose control is of great significance to the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

Correlation between Glycated Haemoglobin Level, Cardiac Function, and Prognosis in Patients with Diabetes Mellitus Combined with Myocardial Infarction

Zeng

An²,

Li³

et al. 2022

Disease Markers

View full text Add to dashboard Cite

show abstract

“…Based on specic epidemiologic studies, individuals who have diabetes have a four times higher chance of mortality from cardiovascular disease (CVD). 5 Studies have revealed a substantial gender disparity in the incidence and prognosis of acute myocardial infarction (MI) and coronary artery disease (CAD). Women are inclined to have potential risks such as systemic hypertension and diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gender on the Outcome of Acute Coronary Syndrome in Type 2 Diabetes Mellitus

Mahmood

Khan²,

Iqbal

et al. 2023

J Gandhara Med Dent Sci

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OBJECTIVES To determine the frequency of acute coronary syndrome presentations among diabetic patients and in-hospital outcomes based on gender variance. METHODOLOGY This observational cross-sectional study was conducted at the cardiology department of the Pakistan Institute of Medical Sciences, Islamabad. 106 consecutive diabetic patients with acute coronary syndrome were enrolled. Patients were assessed for in-hospital outcomes like congestive heart failure, recurrent angina, and mortality. The outcomes were evaluated based on gender. The Chi-Square test was used for significant differences keeping the P value < 0.05. RESULTSThe mean age of the patients was 57.75±8.16 years. Males were 57 (53.8%), and females were 49 (46.2%). Congestive heart failure, re-angina, and mortality were significant in both genders yielding a P value of <0.05. CONCLUSION Diabetes is an important predictor of acute coronary syndrome. The complications related to congestive heart failure and mortality are more prevalent in males than females.

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“…7 Cardiovascular diseases (CVD) are mostly involved in mortality of type 2 diabetic patients accounting for about 75%. 8 According to some epidemiological studies, diabetic patients have four folds increased risk of CVD mortality. 9 Studies have shown a significant gender based difference in the prevalence and prognosis of coronary artery disease and acute myocardial infarction (AMI).…”

Section: Introductionmentioning

confidence: 99%

Diabetic Patients and Their Presentation in Acute Coronary Syndrome With Outcomes: Does Gender Play Role?

Ali¹,

Ashraf²,

Ahmad³

2022

Pak Heart J

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Objectives: To determine the frequency of different acute coronary syndrome (ACS) presentations and their outcomes in diabetic patients and gender based difference. Methodology: This cross sectional study was conducted in Cardiology Department of Khyber Teaching Hospital, Peshawar from 1st January to 31st July 2018. Diabetic patients admitted via emergency department presenting with acute coronary syndrome were included .The patients were followed during their hospital stay for complications like left ventricular failure, recurrent angina and mortality. All the variables were addressed according to gender difference. Chi-square test was used for final analysis. P< 0.05 was considered statistically significant. Results: A total of 388 diabetic patients were included. Of them males were 217 with mean age of 60.64 ± 9.24 years. About 65.46% patients presented to us with acute myocardial infarction. Thrombolytic therapy was done in 78.74% patients. About 86 males and 61 females developed symptoms of heart failure post MI (p < 0.001). In hospital mortality was found to be significant according to gender, p = 0.03. About 48.27% and 44.44% male patients presented with NSTEMI and USA respectively with no significant difference compared to females (p =0.21). However results were significant for stable angina [35.29% females vs. 64.70% males, p <0.001]. Conclusion: Diabetic patients present with coronary artery disease and its complications with heart failure and death more common among males as compared to females, needing special consideration for diagnosis and treatment.

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Changes over Time in Hemoglobin A1C (HbA1C) Levels Predict Long-Term Survival Following Acute Myocardial Infarction among Patients with Diabetes Mellitus

Cited by 5 publications

References 43 publications

Correlation between Glycated Haemoglobin Level, Cardiac Function, and Prognosis in Patients with Diabetes Mellitus Combined with Myocardial Infarction

Correlation between Glycated Haemoglobin Level, Cardiac Function, and Prognosis in Patients with Diabetes Mellitus Combined with Myocardial Infarction

Effect of Gender on the Outcome of Acute Coronary Syndrome in Type 2 Diabetes Mellitus

Diabetic Patients and Their Presentation in Acute Coronary Syndrome With Outcomes: Does Gender Play Role?

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