Changes of the Relative Severity of Naming, Fluency and Recall Impairment in the Course of Dementia of the Alzheimer Type

Pollmann, Stefan; Haupt, Marleen; Kurz, Alexander

doi:10.1159/000106955

Cited by 5 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The early language damage of MCI is created from failure at the pragmatic and semantic level of language process (18). Learning the nature of language performance is highly important as it is associatedd with a faster progression of the disease (19) and brain deterioration (20). Lexical semantic treatment indicates positive therapeutic effects in early AD (20).…”

mentioning

confidence: 99%

Study protocol: Language profile in mild cognitive impairment: A prospective study

Khatoonabadi

Masumi

2019

Med. J. Islam. Republ. Iran

View full text Add to dashboard Cite

Background:The present study will be a longitudinal investigation of language abilities in individuals with mild cognitive impairment (MCI). The research question will include whether there will be an evidence for language impairment in individuals with MCI, and if so, what aspects of language will be the most affected and whether language abilities will be significantly changed over a 12-month period.Methods: We will diagnose 30 individuals with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controlled participants using Montreal Cognitive Assessment-Basic (MoCA-B), as a cognitive test, and by asking expert opinions and conducting interviews. Participants will be selected from memory clinics and nursing homes in Tehran during 2018-2019. A comprehensive language test (Barnes Language Assessment (BLA)) will be performed to obtain baseline performance in the elderly. These tests will be repeated after 3, 6, and 12 months. Repeated measures analysis of variance (ANOVA) will be used to determine whether there will be a significant change in participants' language abilities over a 12-month period. In the case of deficient language performance, a discriminant function analysis will be used to identify the language task type that will be highly sensitive to change. Results and Conclusion:The present study will provide evidence for the nature of language change and will be done in a-year course on individuals with MCI and AD and on healthy elders. Also, in this study, the relative sensitivity of various language components to MCI will be determined, and the relationship between language performance and performance on (MoCA-B) neuropsychological test will be examined.

show abstract

mentioning

confidence: 99%

Study protocol: Language profile in mild cognitive impairment: A prospective study

Khatoonabadi

Masumi

2019

Med. J. Islam. Republ. Iran

View full text Add to dashboard Cite

show abstract

“…Longitudinal studies have shown that the most severe naming deficits increase from mild to moderate dementia. The possible causes are lexical-semantic and visual-perceptive dysfunctions 13 , and the appearance of visuospatial and constructional impairment is most likely due to increasing pathological involvement of the posterior association cortex. The ability to visually discriminate nameable objects in AD also strongly predicts patients' performance in both picture naming and semantic association 32 .…”

Section: Discussionmentioning

confidence: 99%

“…Studying the nature of naming ability is extremely important because anomia is correlated with a more rapid progression of the illness 13 and a greater likelihood of whole-brain atrophy 14 . Moreover, recent studies have shown positive therapeutic effects for lexical semantic treatment in early AD 15 .…”

Section: Introductionmentioning

confidence: 99%

Naming ability in patients with mild to moderate Alzheimer's disease: what changes occur with the evolution of the disease?

Silagi¹,

Bertolucci²,

Ortiz³

2015

Clinics

View full text Add to dashboard Cite

OBJECTIVES:Naming deficit is a linguistic symptom that appears in the initial phase of Alzheimer's disease, but the types of naming errors and the ways in which this deficit changes over the course of the disease are unclear. We analyzed the performance of patients with Alzheimer's disease on naming tasks during the mild and moderate phases and verified how this linguistic skill deteriorates over the course of the disease.METHODS:A reduced version of the Boston Naming Test was administered to 30 patients with mild Alzheimer's disease, 30 patients with moderate Alzheimer's disease and 30 healthy controls. Errors were classified as verbal semantic paraphasia, verbal phonemic paraphasia, no response (pure anomia), circumlocution, unrelated verbal paraphasia, visual errors or intrusion errors.RESULTS:The patients with moderate Alzheimer's disease had significantly fewer correct answers than did both the control group and the group with mild Alzheimer's disease. With regard to the pattern of errors, verbal semantic paraphasia errors were the most frequent errors in all three groups. Additionally, as the disease severity increased, there was an increase in the number of no-response errors (pure anomia). The group with moderate Alzheimer's disease demonstrated a greater incidence of visual errors and unrelated verbal paraphasias compared with the other two groups and presented a more variable pattern of errors.CONCLUSIONS:Performance on nominative tasks worsened as the disease progressed in terms of both the quantity and the type of errors encountered. This result reflects impairment at different levels of linguistic processing.

show abstract

Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis

Han

Cole

Bellavance

et al. 2000

Int. Psychogeriatr.

167

103

View full text Add to dashboard Cite

Objectives: To estimate the annual rate of change scores (ARC) on the Mini-Mental State Examination (MMSE) in Alzheimer's disease (AD) and to identify study or population characteristics that may affect the ARC estimation. Methods: MEDLINE was searched for articles published from January 1981 to November 1997 using the following keywords: AD and longitudinal study or prognosis or cognitive decline. The bibliographies of review articles and relevant papers were searched for additional references. All retrieved articles were screened to meet the following inclusion criteria: (a) original study; (b) addressed cognitive decline or prognosis or course of AD; (c) published in English; (d) study population included AD patients with ascertainable sample size; (e) used either clinical or pathological diagnostic criteria; (f) longitudinal study design; and (g) used the MMSE as one of the outcome measures. Data were systematically abstracted from the included studies, and a random effects regression model was employed to synthesize relevant data across studies and to evaluate the effects of study methodology on ARC estimation and its effect size. Results: Of the 439 studies screened, 43 met all the inclusion criteria. After 6 studies with inadequate or overlapping data were excluded, 37 studies involving 3,492 AD patients followed over an average of 2 years were included in the meta-analysis. The pooled estimate of ARC was 3.3 (95% confidence interval [CI]: 2.9-3.7). The observed variability in ARC across studies could not be explained with the covariates we studied, whereas part of the variability in the effect size of ARC could be explained by the minimum MMSE score at entry and number of assessments. Conclusions: A pooled average estimate of ARC in AD patients was 3.3 points (95% CI: 2.9-3.7) on the MMSE. Significant heterogeneity of ARC estimates existed across the studies and cannot be explained by the study or population characteristics investigated. Effect size of ARC was related to the initial MMSE score of the study population and the number of assessments.

show abstract

Changes of the Relative Severity of Naming, Fluency and Recall Impairment in the Course of Dementia of the Alzheimer Type

Cited by 5 publications

References 14 publications

Study protocol: Language profile in mild cognitive impairment: A prospective study

Study protocol: Language profile in mild cognitive impairment: A prospective study

Naming ability in patients with mild to moderate Alzheimer's disease: what changes occur with the evolution of the disease?

Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis

Contact Info

Product

Resources

About