Changes of the Indices of Lipid Peroxidation and Antioxidant System in Lungs Under Conditions of Experimental Bronchial Asthma With Chronic Periodontitis and Their Correction by Tiotriasolin

Reheda, M. S.; Shchepanskyi, B. F.

doi:10.24061/1727-4338.xvii.2.64.2018.14

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“…Thiotriazoline exhibits antioxidant activity -converts oxygen free radicals and ROS into an inactive state, indirect-reactivates antioxidant enzymes -superoxide dismutase and glutathione peroxidase, and protects endogenous antioxidantsα-tocopherol and glutathione from "overexpenditure," anti-inflammatory effect -reduces the content of circulating immune and immunomodulatory complexes, limits the release of inflammatory mediators by them, reduces the expression of the pro-inflammatory cytokine IL-1b, stabilizes the membranes of basophils, mast cells and eosinophils, increases the phagocytic activity of macrophages, and increases the level of interferon [7]. There are experimental and clinical results of the positive use of thiotriazoline in inflammatory diseases of the oral cavity [8], [9], [10]. A promising agent for the complex therapy of periodontitis is L-arginine, a precursor of NO synthesis [11].…”

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confidence: 99%

Pharmacocorrection of Disturbances in the no System in Experimental Chronic Generalized Periodontitis

Parkhomenko

Бєленічев²,

Bukhtiyarova³

et al. 2023

Open Access Maced J Med Sci

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BACKGROUND: In the light of modern views on the pathogenesis of inflammatory diseases of the oral cavity, a promising direction is the use of agents with metabolitotropic, endothelioprotective, and especially with antioxidant action. AIM: The purpose of this study was to evaluate the effect of a combination of thiotriazoline and L-arginine (1:4) on the parameters of the nitroxidergic system of the blood and periodontium of rats with experimental chronic generalized periodontitis and substantiate further study of this combination. METHODS: Real-time reverse-transcription polymerase chain reaction was used to assess the mRNA expression status of iNOS and nNOS mRNAs. The total content of reduced thiols was also determined by the reaction with Elman’s reagent. RESULTS: We found an increase in the total activity of NOS by 90.01% due to an increase in the expression of iNOS, while a decrease in the expression of its endothelial form was observed (a decrease in the expression of eNOS mRNA by 74.3%) compared with the intact group. An increase in iNOS activity led to an increase in the production of NO, which, under conditions of antioxidant deficiency, is converted into cytotoxic forms (peroxynitrite and nitrosonium ion). CONCLUSIONS: The course administration of Mexidol (250 mg/kg) and, especially, the combination of thiotriazoline and L-arginine (1:4) (200 mg/kg) to animals with CGP, leads to a decrease in the gingival pocket to 6 mm (Mexidol) and to 4 mm against the background almost complete absence of bleeding, swelling, and tooth mobility (combination), and also led to a decrease in iNOS mRNA expression by 65.6% (p < 0.05).

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