Changes of the basement membrane and type IV collagen in human skin during aging

Vázquez, Fernando; Palacios, Santiago; Alemañ, Nuria; Guerrero, Flora

doi:10.1016/s0378-5122(96)01066-3

Cited by 69 publications

(54 citation statements)

References 15 publications

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“…The loss of skin capillary density, called rarefaction [ 131 ] , is paralleled with a loss of skin collagen and elastin [ 11 ] . The basement membrane also increases in thickness with age [ 129 ] .…”

Section: Introduction and Overviewmentioning

confidence: 94%

Skin Moisture and Heat Transfer

Petrofsky

Berk

2012

Treatment of Dry Skin Syndrome

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Section: Introduction and Overviewmentioning

confidence: 94%

Skin Moisture and Heat Transfer

Petrofsky

Berk

2012

Treatment of Dry Skin Syndrome

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“…The basement membrane, a very small fraction of the total skin thickness, actually increases in thickness with age [39].…”

Section: Skin Thicknessmentioning

confidence: 99%

Degenerative Changes in Aging Skin

Farage

Miller

Maibach

2010

Textbook of Aging Skin

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“…Collagen type IV is a major component of the dermal-epidermal junction and attaches to each other to form complex protein networks. In human skin, collagen type IV is a unique basement membrane component and declines with aging [28]. It is well known that menopause-associated estrogen decline affects the reduction of collagen production in postmenopausal women's skin, which accelerates the climacteric skin aging.…”

Section: Effect Of Daidzein On the Expression Of Ecm Componentsmentioning

confidence: 99%

The Phytoestrogenic Effect of Daidzein in Human Dermal Fibroblasts

Kim¹,

Hong²,

Lee³

2014

Journal of the Society of Cosmetic Scientists of Korea

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Abstract:Estrogen deficiency results in a reduction of skin quality and function in postmenopausal women. Over the past decade, many studies have supported that estrogen provides anti-aging effects as a result of the ability of estrogen to prevent skin collagen decline, restore skin elasticity, and increase skin hydration in postmenopausal women skin. Due to their structural similarity with estrogen, isoflavones have been called phytoestrogens. Photoprotective effects of isoflavones are well established while their estrogenic-like activities are not fully understood in human skin. In this study, we investigated whether daidzein, an effective isoflavone, has phytoestrogenic activity and induces transcriptional change of extracellular matrix components in dermal fibroblasts. We examined the luciferase activity of daidzein and β -estradiol using transiently transfected NIH3T3-ERE cells. The estrogenic receptor-dependent transcriptional activity was increased in a dose-dependent manner when treated with daidzein, with a maximum of 2.5-fold induction at 10 µg/mL of daidzein compared with non-treated control. In addition, daidzein significantly in creased the expressions of collagen 1) † 주 저자 (e-mail: misunkim@lgcare.com) 2014 type I, collagen type IV, elastin, and fibrillin-1 in human dermal fibroblasts. By comparing with the effects of β -estradiol through out all the experiments, we confirmed that daidzein had estrogenic activity and function in fibroblasts. These results suggest that daidzein-based application, having both photoprotective and phytoestrogenic effects, may be a powerful approach for skin anti-aging of postmenopausal women.

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Changes of the basement membrane and type IV collagen in human skin during aging

Cited by 69 publications

References 15 publications

Skin Moisture and Heat Transfer

Skin Moisture and Heat Transfer

Degenerative Changes in Aging Skin

The Phytoestrogenic Effect of Daidzein in Human Dermal Fibroblasts

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