Changes of somatosensory evoked potential accompanying ischaemia and hypoxia in cats

Iwayama, Kaoru; Mori, Kazuo; Sakai, Shizuyoshi; Yamashiro, Katsumi; Iwamoto, Kikuo

doi:10.1080/01616412.1986.11739748

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…[8][9][10][11] Although its value in assessing acute hypoxic states is well established, 12,13 its benefit in assessing the effect of chronic hypoxic-hypercapnic states on the nervous system was doubtful. [14][15][16][17][18][19] Cognitive event-related evoked potentials (EREPs) are long-latency potentials obtained during information processing tasks which involve attention, stimulus discrimination, memory, and related processes.…”

Section: Dovepressmentioning

confidence: 99%

Event-related evoked potentials in chronic respiratory encephalopathy

Tahan

Zaidan²,

Jones³

et al. 2010

COPD

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Background:Cognitive event-related potential (P 300 ) is an index of cognitive processing time. It was found to be prolonged in dementia, renal, and hepatic encephalopathies, but was not extensively assessed in respiratory failure. Objective: To evaluate P 300 changes in patients with respiratory failure, and especially those with mild or subclinical hypoxic-hypercapnic encephalopathy. Methods: Auditory event-related evoked potential P 300 latency was measured using an oddball paradigm in patients with respiratory failure due to any cause (partial pressure of oxygen in arterial blood (PO 2 ) should be 75 mm/Hg or less). Apart from blood gases measurement, patients underwent the Mini-Mental State Examination (MMSE). Patient performances were compared with that of matched normal control. Patients were admitted into the study from outpatient clinics and wards at King Khalid University Hospital and Sahara Hospital. Results: Thirty-four patients (12 women, 22 men) were admitted to the study. Ages ranged from 19-67 years with a mean of 46.1 years. Respiratory failure was severe or very severe in 11 patients (33%), and mild or moderate in the rest (66%). Mean value for PO 2 and partial pressure of carbon dioxide in arterial blood (PCO 2 ) were 63.7 and 45.2 mm/Hg, respectively. pH mean was 7.4 and O 2 saturation was 90.7%. P 300 latency ranged from 218 to 393 milliseconds, with a mean of 338.4 milliseconds. In comparison with control (309.9 milliseconds), there was a significant difference (P = 0.007). P 300 amplitude differences were not significant. No significant difference in MMSE was noted between mild and severe respiratory failure. Results of detailed neuropsychological assessment were clearly abnormal but were limited by the small number of tested patients. P 300 latency changes correlated significantly with age as well as severity of respiratory failure. P 300 was also significantly delayed whether hypoxia occurred with or without hypercapnia. Conclusion: Results show a significant delay of P 300 latency in patients with severe and mild respiratory failure. This was associated with subclinical encephalopathy in most patients, evidenced by a near-normal MMSE score. Apart from confirming the importance of P 300 latency measurement as a marker of respiratory encephalopathy, this study asserts the causal relationship between hypoxemia and cognitive derangement. Furthermore, it promotes the early use of oxygen therapy in a selected group of patients with mild or moderate respiratory failure, who have responsibilities which involve taking rapid critical decisions.

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