Effect of graded hypoxia on cortical and spinal somatosensory evoked potentials

Haghighi, Siavash S.; Oró, J.; Gibbs, Scott R.; McFadden, Michael

doi:10.1016/0090-3019(92)90002-5

Cited by 9 publications

(1 citation statement)

References 23 publications

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“…Once established, these changes persisted throughout the duration of the experiment. These data are consistent with the literature, showing that spinal somatosensory-evoked potentials are more resistant to severe hypoxia than cortical somatosensory-evoked potentials ( 27 ). In addition, the data indicate that the spinal nociceptive reflexes (TFT) are more resistant to CoCl 2 hypoxic preconditioning than supraspinal responses to nociception (HPT).…”

Section: Discussionsupporting

confidence: 93%

Preconditioning with cobalt chloride modifies pain perception in mice

Alexa

Luca

Dondas

et al. 2015

Experimental and Therapeutic Medicine

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Cobalt chloride (CoCl2) modifies mitochondrial permeability and has a hypoxic-mimetic effect; thus, the compound induces tolerance to ischemia and increases resistance to a number of injury types. The aim of the present study was to investigate the effects of CoCl2 hypoxic preconditioning for three weeks on thermonociception, somatic and visceral inflammatory pain, locomotor activity and coordination in mice. A significant pronociceptive effect was observed in the hot plate and tail flick tests after one and two weeks of CoCl2 administration, respectively (P<0.001). Thermal hyperalgesia (Plantar test) was present in the first week, but recovered by the end of the experiment. Contrary to the hyperalgesic effect on thermonociception, CoCl2 hypoxic preconditioning decreased the time spent grooming the affected area in the second phase of the formalin test on the orofacial and paw models. The first phase of formalin-induced pain and the writhing test were not affected by CoCl2 preconditioning. Thus, the present study demonstrated that CoCl2 preconditioning has a dual effect on pain, and these effects should be taken into account along with the better-known neuro-, cardio- and renoprotective effects of CoCl2.

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Section: Discussionsupporting

confidence: 93%