Changes of Skin Microcirculation in Patients with Chronic Venous Insufficiency Assessed by Laser Doppler Fluxmetry and Transcutaneous Oxymetry

Creutzig, A; Caspary, L; Alexander, Klaus

doi:10.1177/026835559400900406

Cited by 18 publications

(17 citation statements)

References 15 publications

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“…Measurements show an increased median basal resting flux in patients with CVI and AB lesions compared with normal skin. 90–93 Venous hypertension results in a similar decrease of flux in AB lesions or normal skin (46% in normal, 56% in AB lesions). 93 …”

Section: Microcirculationmentioning

confidence: 95%

Atrophie blanche

et al. 1999

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Section: Microcirculationmentioning

confidence: 95%

Atrophie blanche

et al. 1999

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“…They found that a single IPC treatment diminished the laser Doppler £ux and enhanced the venoarteriolar response of the skin in legs with CVI. Other investigators (8,10,14), have, however, found the venoarteriolar response to be una¡ected in legs with CVI compared with healthy legs. Pryce & Friedmann (9) found the venoarteriolar response to be increased in legs with CVI compared with healthy legs.…”

Section: Discussionmentioning

confidence: 91%

“…The arterial resistance is lowered at angiography (16^18) and the oxygen content of venous blood is elevated in legs with CVI (16,19). Accordingly, the transcutaneous oxygen tension (TcPO 2 ) is lowered (5^7, 13,14) and oxygen extraction is reduced (15) in the skin of legs with CVI. All these ¢ndings can re£ect enhanced whole skin blood £ow while there is ischaemia in the nutritional capillary bed (34).…”

Section: Discussionmentioning

confidence: 99%

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The Role of Low Resistance Blood Flow Pathways in the Pathogenesis and Healing of Venous Leg Ulcers

Malanin

Kolari²,

Havu³

1999

Acta Dermato-Venereologica

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In an attempt to clarify the pathophysiology of haemodynamics in legs with venous ulcer we investigated the effect of a single intermittent pneumatic compression treatment on the peripheral resistance of leg arteries and the cutaneous laser Doppler flux in the leg. Eight patients with venous leg ulcers and 10 subjects with healthy legs were investigated. Doppler waveforms of the leg arteries and laser Doppler flux of the leg skin were recorded before and after a single intermittent pneumatic compression treatment with the subjects in a recumbent position. In the legs with venous ulcer, the peripheral resistance of the arteries was lower and the laser Doppler flux was greater, compared with healthy legs (p = 0.003 and p = 0.002, respectively). A single intermittent pneumatic compression treatment raised the peripheral resistance in the arteries of legs with ulcer and laser Doppler flux of the skin more in ulcer legs than in healthy legs (p = 0.046 and p = 0.034, respectively). These findings suggest that removal of oedema causes redistribution of skin blood flow in the legs with venous ulcer favouring the superficial capillary perfusion. This could explain why compression treatment promotes the healing of venous leg ulcers.

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“…Chronic venous insufficiency (CVI) has been shown to be associated with biochemical abnormalities in the vein wall and functional abnormalities ranging from haemorheological changes [1][2][3][4], increased capillary permeabili ty, trapping of white blood cells [5][6][7], deficiencies of pro teins involved in coagulation and fibrinolytic systems [8] to microcirculatory changes [9][10][11][12]. These disorders are aggravated by venous hypertension produced by standing or sitting as well as by venous occlusion [1,2, 13, 14] and may lead to trophic skin changes and ulceration.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Haemorheological and Microcirculatory Disturbances in Chronic Venous Insufficiency: Activity of DafIon 500 mg

Devehat

Khodabandehlou²,

Vimeux

et al. 1997

Int J Microcirc

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The use of Daflon 500 mg has been shown to improve venous tone, microvascular permeability, lymphatic activity, and microcirculatory nutritive flow. This study aimed to assess the effects of Daflon 500 mg at a daily dose of 2 tab/day on microcirculatory, haemorheologic parameters, white blood cell counts and neutrophil activation in patients suffering from chronic venous insufficiency (CVI). This was a single-centre double-blind placebo-controlled study comparing two parallel groups of CVI patients who were treated for 2 months with Daflon 500 mg (n = 39) or placebo (n = 38). Evaluations were performed before treatment (D₀) and at the end of treatment (D₆₀). Blood samples were drawn from a foot vein before and at the end of a 15-min period of venous hypertension provoked by a cuff inflated to 100 mm Hg. Red blood cell (RBC) deformability was determined by the initial flow rate filtration technique using a Hanss haemorheometer. RBC aggregation was evaluated by a Myrenne aggregometer based on analysis of transmitted light through a blood sample during flow. RBC disaggregation was evaluated by Sefam erythro-aggregometer based on analysis of the backscattered light through a blood sample in a Couette flow. Microcirculatory parameters were assessed by means of laser Doppler fiuxmetry and transcutaneous oxymetry measurements and consisted of continuous records of blood flux (BF) and TcPO₂ before and during 15 min of venous hypertension. Results are expressed as absolute values at baseline (before stasis) and at the end of stasis, before and after 2 months of treatment. Univariate analysis showed a significant reduction of the stasis-induced RBC aggregation index (Daflon 500 mg: -0.07 ± 0.20; placebo: 0.04 ± 0.18; mean ± SD; p = 0.03). Multivariate analysis identified a subset of 5 variables (RBC aggregation, RBC count, microcirculatory BF, amplitude and frequency of vasomotion) that produced a good discrimination model between the two treatments. Linear combination of these 5 variables in 48 patients with complete data showed a significant difference (p < 0.001) between the groups. These changes suggest a protective effect of Daflon 500 mg on the deleterious influence of stasis on microcirculatory (BF) and hemorheologic (RBC aggregation) parameters in CVI patients in comparison to patients receiving placebo.

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Changes of Skin Microcirculation in Patients with Chronic Venous Insufficiency Assessed by Laser Doppler Fluxmetry and Transcutaneous Oxymetry

Cited by 18 publications

References 15 publications

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The Role of Low Resistance Blood Flow Pathways in the Pathogenesis and Healing of Venous Leg Ulcers

Evaluation of Haemorheological and Microcirculatory Disturbances in Chronic Venous Insufficiency: Activity of DafIon 500 mg

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