Changes of Serum Omentin Levels and Relationship between Omentin and Adiponectin Concentrations in Type 2 Diabetes Mellitus

Yan, Pingping; Liu, D; Long, Min; Ren, Yongcheng; Pang, Jingbo; Li, R

doi:10.1055/s-0030-1269912

Cited by 96 publications

(104 citation statements)

References 41 publications

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“…Thus it is hardly surprising that circulating levels of www.intechopen.com omentin/intelectin are negatively correlated with the extent of carotid intima-media thickness (Shibata et al, 2011) since they are probably derived from the endothelial cells of the blood vessels. Female subjects have higher circulating levels of omentin than male subjects and those levels correlate with the circulating levels of adiponectin, both being negatively associated with insulin resistance (Yan et al, 2011). These findings confirm the original report by de Souza Batista et al, (2007) that circulating levels of omentin/intelectin are negatively correlated with BMI and insulin resistance.…”

Section: Omentin/intelectinsupporting

confidence: 89%

Effect of Obesity on Circulating Adipokines and Their Expression in Omental Adipose Tissue of Female Bariatric Surgery Patients

Fain¹

2012

Advanced Bariatric and Metabolic Surgery

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Section: Omentin/intelectinsupporting

confidence: 89%

Effect of Obesity on Circulating Adipokines and Their Expression in Omental Adipose Tissue of Female Bariatric Surgery Patients

Fain¹

2012

Advanced Bariatric and Metabolic Surgery

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“…However, decreased omentin mRNA expression levels were reported in patients with type 2 diabetes and obesity [23]. In two recent studies, serum omentin levels were lower in patients with type 2 diabetes and impaired glucose regulation than in the normal glucose tolerance group [24,25].…”

Section: Discussionmentioning

confidence: 99%

“…They showed that serum RBP4 levels were elevated in GLUT4 glucose transporter knockout mice and humans with obesity and type 2 diabetes [11]. Currently, increasing evidence denotes an association between increased circulating levels of RBP4 with type 2 diabetes mellitus and/or insulin resistance states [11,25,12,[26][27][28][29][30][31]. A pathophysiological link between RBP4 and type 2 diabetes mellitus may also arise from impaired insulin secretion [3].…”

Section: Discussionmentioning

confidence: 99%

The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels

Akbarzadeh¹,

Nabipour²,

Assadi³

et al. 2012

Cytokine

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a b s t r a c tObjective: It has been suggested that adipose-derived cytokines act as insulin sensitizers/insulin-mimetics and some others may induce insulin resistance. In order to elucidate the potential role of novel adipocytokines in the pre-diabetes states, circulating levels of novel adipocytokines were evaluated in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs). Method: Serum omentin-1, adiponectin and retinol-binding protein 4 (RBP4) levels were measured in 179 subjects (90 glucose tolerant FDRs and 89 age-and sex-matched healthy controls) using enzymelinked immunosorbent assay (ELISA) methods. Results: There was no significant difference between the two groups regarding serum RBP4 concentrations. However, serum omentin-1 (median [interquartile range], 6.18 [4.06-11.52] ng/ml versus 10.50 [4.30-20.60] ng/ml, p = 0.004) and adiponectin (mean ± SD, 10.07 ± 4.0 lg/ml versus 20.66 ± 8.12 lg/ml, p < 0.0001) levels were significantly lower in FDRs when compared with the controls. In multiple logistic regression analysis, FDRs showed a significant association with lower circulating omentin-1 and adiponectin levels, even after adjustments were made for age, sex, body mass index, blood pressure measures, and biochemical parameters including glucose status, lipid profile, insulin levels and HOMA-IR (OR = 0.49, p = 0.004 and OR = 0.74,; p < 0.0001, respectively). However, FDRs did not show a significant association with serum RBP4 levels in different models of regression analyses. Conclusions: The FDRs showed significant associations with lower omentin-1 and adiponectin levels. A potential role for these adipokines in the FDRs' increased risk of diabetes needs to be further elucidated.

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“…Serum omentin-1 concentrations were reported to correlate passively with BMI and waist circumference [5] . Decreased serum level of omentin-1 was reported in polycystic ovary syndrome [6] , diabetes [7] and coronary artery disease [8] . Moreover, omentin was reported to prevent apoptosis of cardiomyoblasts via inhibition of mitochondrial ROS production [9] .…”

Section: Introductionmentioning

confidence: 99%

Omentin-1 in serum and seminal plasma correlate with semen quality

et al. 2017

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Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types. Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia. Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS). Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men. Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.

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Changes of Serum Omentin Levels and Relationship between Omentin and Adiponectin Concentrations in Type 2 Diabetes Mellitus

Abstract: Serum omentin levels possibly play an important role in the pathogenesis of insulin resistance and diabetes. More importantly, there is such a close connection between serum omentin and adiponectin levels that regulation of omentin may be dependent on adiponectin.

Cited by 96 publications

References 41 publications

Effect of Obesity on Circulating Adipokines and Their Expression in Omental Adipose Tissue of Female Bariatric Surgery Patients

Effect of Obesity on Circulating Adipokines and Their Expression in Omental Adipose Tissue of Female Bariatric Surgery Patients

The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels

Omentin-1 in serum and seminal plasma correlate with semen quality

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