Changes of serum lipocalin-2 and retinol binding protein-4 levels in patients with psoriasis and Behçet's disease

Gül, Feride Çoban; Çiçek, Demet; Kaman, Dilara; Demir, Betül; Nazik, Hülya

doi:10.1684/ejd.2014.2490

Cited by 11 publications

(18 citation statements)

References 7 publications

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“…It suggests that LCN2 might play an important role in potential psoriasis/PsA pathogenesis. Some studies have shown that serum LCN2 is not related to BMI and disease activity in psoriasis/PsA patients [13, 20]. Moreover, there are conflicting results regarding the correlation between serum LCN2 and PASI [12, 15].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the functions of LCN2 extend beyond those of antimicrobials, and it has also been implicated in the progression of various diseases including infectious disease, cardiac disease, renal injury, tumor metastasis, and chronic inflammatory pain, among others [16–18]. Moreover, some studies have reported that serum LCN2 levels are increased in psoriasis patients than controls [19, 20]. LCN2 is suggested to be involved in the pathogenesis of psoriasis/PsA by modulating neutrophil function and enhancing T-helper 17 response [21, 22].…”

Section: Introductionmentioning

confidence: 99%

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Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

2019

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Objectives. The purpose of this study was to explore the association of serum lipocalin-2 concentrations with psoriasis and psoriatic arthritis (PsA). Methods. A systematic search of studies on the association of serum lipocalin-2 concentrations with psoriasis/PsA was conducted in PubMed, Web of Science, Elsevier ScienceDirect, and Cochrane Library. Eventually, 8 eligible studies were included. The strength of association between serum lipocalin-2 concentrations and psoriasis/PsA was assessed by pooled standard mean difference (SMD) with its 95% confidence intervals (CIs). Results. A total of 8 case-control studies, consisting of 349 psoriasis/PsA patients and 258 controls, were included in the meta-analysis. This meta-analysis showed significant association between serum lipocalin-2 concentrations and psoriasis/PsA in overall population (SMD: 0.757, 95%CI=0.588‐0.926, and PH=0.114; PH is the P value for the heterogeneity test). Similar results were found in subgroup analysis by ethnicity. Conclusions. Serum lipocalin-2 concentrations are higher in psoriasis/PsA patients than controls. However, more large-scale studies are warranted to explore the association between serum lipocalin-2 and the pathogenetic mechanisms of psoriasis/PsA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

2019

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“…In the field of uveitis, lcn2 was reported to be highly induced in the equine recurrent uveitis model [72] . As concerns humans, lcn2 serum levels are increased in patients with Behçet's disease and psoriasis compared to controls [73] . Furthermore, lcn2 concentration in aqueous humor is increased in eyes with idiopathic acute anterior uveitis [47].…”

Section: Discussionmentioning

confidence: 96%

Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach

et al. 2020

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Background: Blood-retinal barrier cells are known to exhibit a massive phenotypic change during experimental autoimmune uveitis (EAU) development. In an attempt to investigate the mechanisms of blood-retinal barrier (BRB) breakdown at a global level, we studied the gene regulation of total retinal cells and retinal endothelial cells during non-infectious uveitis. Methods: Retinal endothelial cells were isolated by flow cytometry either in Tie2-GFP mice (CD31 + CD45 − GFP + cells), or in wild type C57BL/6 mice (CD31 + CD45 − endoglin + cells). EAU was induced in C57BL/6 mice by adoptive transfer of IRBP1-20-specific T cells. Total retinal cells and retinal endothelial cells from naïve and EAU mice were sorted and their gene expression compared by RNA-Seq. Protein expression of selected genes was validated by immunofluorescence on retinal wholemounts and cryosections and by flow cytometry. Results: Retinal endothelial cell sorting in wild type C57BL/6 mice was validated by comparative transcriptome analysis with retinal endothelial cells sorted from Tie2-GFP mice, which express GFP under the control of the endothelial-specific receptor tyrosine kinase promoter Tie2. RNA-Seq analysis of total retinal cells mainly brought to light upregulation of genes involved in antigen presentation and T cell activation during EAU. Specific transcriptome analysis of retinal endothelial cells allowed us to identify 82 genes modulated in retinal endothelial cells during EAU development. Protein expression of 5 of those genes (serpina3n, lcn2, ackr1, lrg1 and lamc3) was validated at the level of inner BRB cells. Conclusion: Those data not only confirm the involvement of known pathogenic molecules but further provide a list of new candidate genes and pathways possibly implicated in inner BRB breakdown during non-infectious posterior uveitis.

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“…RBP-4 is associated with chronic liver diseases such as cirrhosis and non-alcoholic fatty liver disease [29]. Also, RBP-4 seems to be associated with inflammatory processes and several diseases such as inflammatory bowel disease [30], psoriasis [31], cardiomyopathy [32], and cancer [33]. Nevertheless, the mechanisms of the association between RBP-4 and these diseases are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

Kim

Song

Seo

et al. 2021

Korean J Intern Med

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Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin sensitivity. We evaluated the association between metabolic parameters and allergic sensitization in the elderly. Methods: We analysed the database of the Korean Longitudinal Study on Health and Aging cohort study conducted during 2005 to 2006. Atopy was identified by inhalant allergen skin prick test. Metabolic conditions were assessed using anthropometric indices and serum biomarkers such as fasting glucose, lipid, adiponectin, and RBP-4. Results: Among the 854 elderly subjects, 17.2% had atopy. Plasma RBP-4 levels were significantly higher in the atopic elderly than nonatopic elderly (p = 0.003). When RBP-4 percentiles were categorized as under three groups, the prevalence of atopy and current rhinitis increased significantly with percentiles of RBP-4 levels (p = 0.019 and p = 0.007, respectively). Log RBP-4 was associated with atopy (odds ratio [OR], 4.10; p = 0.009) and current rhinitis (OR, 2.73; p = 0.014), but not with current asthma (OR, 1.17; p = 0.824). Higher RBP-4 level in atopic elderly was also observed in current rhinitis patients. Atopy, but not current rhinitis, showed significant relationships with log RBP-4 levels in multivariate analyses adjusted for other metabolic markers including body mass index. Conclusions: RBP-4 positively associated with atopy in the general elderly population irrespective of other metabolic markers.

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Changes of serum lipocalin-2 and retinol binding protein-4 levels in patients with psoriasis and Behçet's disease

Cited by 11 publications

References 7 publications

Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach

Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population

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