Changes of procollagen type III N-terminal propeptide (PIIINP) concentrations during healing of mandible fractures treated with biodegradable and titanium fixations

Borys, Jan; Antonowicz, Bożena; Grabowska, S

doi:10.2478/ams-2013-0019

Cited by 2 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In mature bone, type I collagen accounts for more than 90% of the bone organic matrix (2) (8) found that PINP is highly specific to bone tissue and is closely related to bone resorption. In this experiment, the changes in PICP and PINP were almost the same.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of revascularisation on the healing of free bone grafts in dogs

Zheng

Ruan

Shuang-Qiu

et al. 2020

Journal of Veterinary Research

View full text Add to dashboard Cite

IntroductionThe therapeutic effect of subcutaneous embedding and revascularisation on the repair of canine bone defects caused by open fracture was examined.Material and MethodsA total of 12 adult beagle dogs were randomly split into a control group (group C) and a test group (group T). A section of the radius was removed from each dog under general anaesthesia and the deficit supported by an orthopaedic implant. Group T had the section surgically implanted next to the blood vessel–rich saphenous vein and Group C had it cryopreserved at −80°C. After eight weeks, the bone was surgically implanted back into the matching radial deficit. Bone healing was evaluated by gross morphological and X-ray examinations, post-mortem histology, and successive blood measurements of key bone biochemical markers.ResultsAt 12 weeks, the bone healing boundary was disappearing more quickly in group T dogs than in their group C counterparts. X-ray and histological examinations showed that the cortical repair of group T subjects was complete and the bony plate arrangement was more regular than that in group C. The levels of bone biochemical markers also proved that the healing state of group T was better.ConclusionThe results showed that the degree of healing, osteoclast activity, and bone formation status of group T were better than those of group C, proving that the vascularised bone graft had a significantly shorter healing time than the cryopreserved bone graft.

show abstract

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of revascularisation on the healing of free bone grafts in dogs

Zheng

Ruan

Shuang-Qiu

et al. 2020

Journal of Veterinary Research

View full text Add to dashboard Cite

show abstract

The nature of changes in endocrine and immune factors at the initial stage of the formation of chronic wounds

Pavlov

Тамм

Komisova

et al. 2023

Modern Medical Technology

View full text Add to dashboard Cite

Aim. The work aimed to study the nature of changes in endocrine signals (insulin and cortisol) and bioactive molecules that control inflammation and activation of process synthesis (interleukin-2 (IL-2), interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), amino-terminal propeptide of type III procollagen (PIIINP)), at the initial stage of the formation of chronic wounds in the experiment. Materials and methods. The study was conducted in 2 groups of Wistar rats. The first group is represented by intact animals. Animals of the second group were modeled chronic wounds. On the 3rd day of the experiment, all animals were euthanized. The concentration of studied bioactive molecules was measured in blood serum by enzyme immunoassay. Selected areas of the wound were subjected to histological examination. Results. The levels of cortisol, insulin, VEGF, IL-2, and PIIINP in animals with chronic wounds at the stage of inflammation were significantly higher compared to intact animals. A tendency towards a decrease in the expression of IL-8 was shown. Relationships between the levels of bioactive molecules in animals of different groups were studied. According to the results of studies a correlation between the concentrations of IL-8 and cortisol in rats of the intact group was established. In the group of rats on the 3rd day after wound induction, a positive correlation was noted between the levels of IL-8 and IL-2. Wound defects healed under the scab. Microscopic analysis showed that the histoarchitectonics of tissues in the area of damage on the 3rd day corresponded to the classic manifestations of the process of healing wounds at this stage. The main part of the wound was filled with fibrin strands with a predominantly inflammatory cellular component. In some areas, signs of growth and development of young granulation tissue were noted. In the marginal sections, signs of re-epithelialization of the wound defect were observed. Conclusions. Even though in our study, the histoarchitectonics of tissues in the area of damage corresponded to the classical manifestations of the wound healing process at the stage of inflammation, the obtained changes and the relationship between endocrine and immune factors may be harbingers of the formation of the chronic wound in the future.

show abstract

Changes of procollagen type III N-terminal propeptide (PIIINP) concentrations during healing of mandible fractures treated with biodegradable and titanium fixations

Cited by 2 publications

References 27 publications

Therapeutic effects of revascularisation on the healing of free bone grafts in dogs

Therapeutic effects of revascularisation on the healing of free bone grafts in dogs

The nature of changes in endocrine and immune factors at the initial stage of the formation of chronic wounds

Contact Info

Product

Resources

About