Changes of oxidative stress in various tissues by long-term administration of vitamin E in hypercholesterolemic rats

Gökkuşu, Cahide; Mostafazadeh, Tannaz

doi:10.1016/s0009-8981(02)00388-1

Cited by 54 publications

(29 citation statements)

References 32 publications

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“…In our study, plasma TBARS levels decreased significantly on adding vitamin E to the rabbits fed on high-fat, high-cholesterol chows, which is in concordance with previous reports (table 3, C+E group) [30, 31]. However, 6-week vitamin E supplement could not prevent atherosclerosis induced by high-fat, high-cholesterol chows (fig.…”

Section: Discussionsupporting

confidence: 93%

Higher Glutathione Peroxidase Expression in Thoracic Aorta as a Protective Factor against Oxidative Stress and Atherosclerosis in Rabbits

Lin

Hsu²,

Lin³

et al. 2007

Cardiology

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Section: Discussionsupporting

confidence: 93%

Higher Glutathione Peroxidase Expression in Thoracic Aorta as a Protective Factor against Oxidative Stress and Atherosclerosis in Rabbits

Lin

Hsu²,

Lin³

et al. 2007

Cardiology

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“…Lipid peroxide level was significantly decreased in the groups fed red garlic extract; such that the level in the groups fed 5-7% extract was lower compared to the groups fed 1-3% of red garlic extract. Lipid peroxide level in serum increased with high fat diet consumption [15], high fat diet was more prone to oxidation and generation of free radicals which was positively correlated with total cholesterol and triglyceride in serum [39].…”

Section: Lipid Peroxidation and Antioxidant Activity In Serummentioning

confidence: 99%

Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet

Lee¹,

Kim²,

Ryu³

et al. 2011

Journal of Life Science

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This study tested the anti-obesity and hypolipidemic effects of red garlic extract in obese rats induced by a high fat diet over a period of 4 weeks. Red garlic extract of 15 brix was added in 1, 3, 5 and 7% ratios in diets. The obesity index and body fat content significantly decreased in rats fed a diet with over 3% red garlic extract compared to the control group. There was no significant difference in weight of visceral and epididymal fat in rats fed red garlic extract. Total lipid and triglyceride levels in serum were significantly decreased in a dose-dependent manner, and AI and CRF also fell. ALT and AST activities in groups fed red garlic extract were decreased compared to the control group. Total lipid level in liver tissue of the groups fed 5-7% red garlic extract exhibited a significant decrease compared to the control group. Total cholesterol and triglyceride levels in feces were significantly increased in rats fed a diet with over 5% red garlic extract. Lipid peroxide levels were significantly decreased in the groups fed diets with 5-7% red garlic and antioxidant activity in serum was significantly increased in the group fed a diet with 7% red garlic extract compared to the control group. Our results suggest that red garlic extract could have anti-obesity and hypolipidemic effects for suppressing obesity index and decreasing lipid profiles. IntroductionAs the choice for a high-calorie and high-fat diet increases due to the economic stability and affluence, so does the occurrence of metabolic disease caused by over-weight [27]. Obesity is the condition under which surplus energy is accumulated as lipids, which is attributable to the increase of energy intake and the decrease of consumption. From the balance is lost, obesity or hyperlipidemia develops, leading to a serious disease. In Korea, the social and economic cost incurred by the increase of obese population rises annually. Given that 40% of people who die by circulating system disease including atherosclerosis, cerebro-, cardio-vascular complications, hypertention, diabetes and functional depression of certain organs are obese, it is necessary to take a fundamental measure to improve the situation [47].Although the drug therapy proved to be effective as a behavior correction therapy used for the control of lipid metabolism in obese, it accompanies side-effects such as headaches, insomnia, and vomiting [29]. Thus, there is a growing attention on the way to improve obesity using phyto-nutrient that does not cause side-effects, among which garlic is known to effective for the control of lipid metabolism and obesity [1,16,24,31,51]. A major bioactive substances of garlic (Allium sativum L.) are an organic sulfur compounds containing allicin [11,18,22], which has the cardioprotective function among others [25]. Reportedly in Korea, the bioactive effect is elevated through the heat-treatment which turns fresh garlic into aged black garlic [22,46] supplemented with 5% red garlic extract, RG-7: supplemented with 7% red garlic extract. production of t...

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“…12,13 Vitamin E is a widely studied antioxidant molecule and several authors have proposed that vitamin E supplementation could be useful in disturbances that are associated with oxidative stress. [14][15][16][17] In the present study, our aim was to evaluate the oxidant and antioxidant status and serum paraoxonase activity in hypothyroidism and to examine the effects of vitamin E on this clinical state. To our knowledge there is no previous report of investigation of either serum paraoxonase/arylesterase activities or antioxidant effects of vitamin E supplementation in hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation

Sarandöl

Taş

Dirican

et al. 2004

Cell Biochem. Funct.

110

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Thyroid hormones are associated with the oxidative and antioxidative status of the organism. Since data on the oxidative status of hypothyroidism are limited and controversial, we investigated the oxidant and antioxidant status and serum paraoxonase/arylesterase activities in propylthiouracil-induced hypothyroidism and examined the effect of vitamin E supplementation on this experimental model. Forty male Sprague Dawley rats were randomly divided into four groups (group 1, control; group 2, control + vitamin E; group 3, propylthiouracil; group 4, propylthiouracil + vitamin E). Plasma, red blood cell, liver, heart and skeletal muscle malondialdehyde levels were increased in the propylthiouracil-treated group compared with the control rats and were decreased in propylthiouracil + vitamin E group compared with the propylthiouracil-treated group. Vitamin E supplementation also significantly increased liver and kidney reduced glutathione levels in propylthiouracil treated animals. Serum paraoxonase and arylesterase activities were decreased in propylthiouracil treated group and vitamin E supplementation caused significant increase in serum paraoxonase activity compared with the propylthiouracil-treated rats. These findings suggest that hypothyroidism is accompanied with increased oxidative stress and vitamin E supplementation exerts beneficial effects on this situation.

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Changes of oxidative stress in various tissues by long-term administration of vitamin E in hypercholesterolemic rats

Cited by 54 publications

References 32 publications

Higher Glutathione Peroxidase Expression in Thoracic Aorta as a Protective Factor against Oxidative Stress and Atherosclerosis in Rabbits

Higher Glutathione Peroxidase Expression in Thoracic Aorta as a Protective Factor against Oxidative Stress and Atherosclerosis in Rabbits

Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet

Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation

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