Higher Glutathione Peroxidase Expression in Thoracic Aorta as a Protective Factor against Oxidative Stress and Atherosclerosis in Rabbits

Lin, Ming‐Chung; Hsu, Hsiu-Ching; Lin, Lung-Chun; Li, Chung‐Yi; Lee, Bai-Chin; Lee, Yuan‐Teh; Chen, Ming-Fong

doi:10.1159/000099112

Cited by 10 publications

(2 citation statements)

References 53 publications

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“…GPxs include five members and have been found in different tissues of the body and cell fractions. As expected, GPxs, a major defender against oxidative stress were also reported to be involved in Parkinson’s disease [ 25 - 27 ], Alzheimer’s disease [ 28 - 30 ], atherosclerosis [ 31 - 32 ], myocardial infarction [ 33 - 34 ], heart failure [ 35 - 36 ], Sickle cell disease [ 37 ], as well as carcinogenesis [ 24 , 38 - 39 ]. In this review we analyzed the role and function of GPxs in mammalian cells, in the regulation of stem cells and cancer stem cells (CSC), discussed the GPxs-mediated signaling pathways and their potential as biomarkers and drug targets.…”

Section: Introductionmentioning

confidence: 82%

Glutathione peroxidases as oncotargets

Jiao¹,

Wang

Guo

et al. 2017

Oncotarget

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Oxidative stress is a disturbance in the equilibrium among free radicals, reactive oxygen species, and endogenous antioxidant defense mechanisms. Oxidative stress is a result of imbalance between the production of reactive oxygen and the biological system’s ability to detoxify the reactive intermediates or to repair the resulting damage. Mounting evidence has implicated oxidative stress in various physiological and pathological processes, including DNA damage, proliferation, cell adhesion, and survival of cancer cells. Glutathione peroxidases (GPxs) (EC 1.11.1.9) are an enzyme family with peroxidase activity whose main biological roles are to protect organisms from oxidative damage by reducing lipid hydroperoxides as well as free hydrogen peroxide. Currently, 8 sub-members of GPxs have been identified in humans, all capable of reducing H2O2 and soluble fatty acid hydroperoxides. A large number of publications has demonstrated that GPxs have significant roles in different stages of carcinogenesis. In this review, we will update recent progress in the study of the roles of GPxs in cancer. Better mechanistic understanding of GPxs will potentially contribute to the development and advancement of improved cancer treatment models.

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Section: Introductionmentioning

confidence: 82%

Glutathione peroxidases as oncotargets

Jiao¹,

Wang

Guo

et al. 2017

Oncotarget

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“…Ascending and arch of aorta were excluded as these aortic parts are highly atherosclerosis-prone and lesions, here, completely surround the orifices. So patterns of lesion development are difficult to demonstrate in these parts of aorta (Vanderlaan et al;Lin et al, 2007). Interestingly, descending thoracic and abdominal aorta showed contrasting patterns.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Sudanophilic Lesions at Ostia of Descending Thoracic and Abdominal Aorta in Cholesterol-Fed Adult Rabbits

Shahid¹,

Butt²,

Zareen³

2011

Int. J. Morphol.

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SUMMARY:Sudan-positive atherosclerotic lesions preferentially occur at downstream and lateral margins of arterial branch ostia in human neonates and weanling rabbits but tend to develop at lateral and upstream margins in old subjects. We investigated (i) the pattern of sudanophilic lesions at aortic ostia of cholesterol-fed adult rabbits and (ii) determined any differences in lesion distribution between descending thoracic and abdominal aorta. Ten adult males, New Zealand white rabbits were fed 2% high cholesterol diet. After six weeks, aortas were excised, opened longitudinally and stained with Sudan-IV for gross examination of atherosclerotic lesions. A total of 156 descending thoracic and 90 abdominal ostia were examined. Mean lesion frequencies upstream, downstream and at lateral margins of the affected ostia were calculated and compared. Sudanophilic lesions were detected around 32% ostia of descending thoracic aorta and 25% those of abdominal aorta. At ostia of descending thoracic aorta, lesion frequencies were significantly higher (P<0.001) downstream (95%) and at lateral margins (92%) than upstream (2%). In abdominal aorta, lateral (100%) and upstream (43%) margins were significantly (P<0.05) more affected while minimal lesion frequencies were seen at downstream branch points (9%). Comparison between descending thoracic and abdominal aorta showed an insignificant difference of lesion frequencies at lateral margins (P>0.05) but a highly significant difference at upstream versus downstream of ostia (P<0.001). We concluded that in cholesterol-fed adult rabbits, juvenile pattern of downstream lipid deposition persists at ostia of descending thoracic aorta while a switch towards the upstream pattern of old subjects occurs at ostia of abdominal aorta.

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