Changes of
            <i>BDNF</i>
            exon IV DNA methylation are associated with methamphetamine dependence

Iamjan, Sri-arun; Thanoi, Samur; Watiktinkorn, Paritat; Fachim, Helene; Dalton, Caroline; Nudmamud-Thanoi, Sutisa; Reynolds, Gavin P.

doi:10.2217/epi-2020-0463

Cited by 15 publications

(9 citation statements)

References 62 publications

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“…The DNA methylation level of the exon region in A. japonicus intestine during aestivation (Yang et al, 2020) was lower than that in our study. We speculate that the difference may be related to temperature selection, because temperature can affect the methylation level of exons (Iamjan et al, 2021). The DNA methylation characteristics of different tissues after heat stress might be different, and WGBS data are needed for more tissue types in the future.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide DNA methylation and transcription analysis reveal the potential epigenetic mechanism of heat stress response in the sea cucumber Apostichopus japonicus

Chang

Liao

et al. 2023

Front. Mar. Sci.

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DNA methylation is an important epigenetic modification that regulates many biological processes. The sea cucumber Apostichopus japonicus often suffers from heat stress that affects its growth and leads to significant economic losses. In this study, the mRNA expression patterns and DNA methylation characteristics in the body wall of A. japonicus under heat stress were analyzed by whole-genome bisulfite sequencing (WGBS) and transcriptome sequencing (RNA-seq). We found that CpG was the main DNA methylation type, and heat stress caused a significant increase in the overall methylation level and methylation rate, especially in the intergenic region of the A. japonicus genome. In total, 1,409 differentially expressed genes (DEGs) and 17,927 differentially methylated genes (DMGs) were obtained by RNA-seq and WGBS, respectively. Association analysis between DNA methylation and transcription identified 569 negatively correlated genes in both DMGs and DEGs, which indicated that DNA methylation affects on transcriptional regulation in response to heat stress. These negatively correlated genes were significantly enriched in pathways related to energy metabolism and immunoregulation, such as the thyroid hormone signaling pathway, renin secretion, notch signaling pathway and microRNAs in cancer. In addition, potential key genes, including heat shock protein (hsp70), calcium-activated chloride channel regulator 1(clca1), and tenascin R (tnr), were obtained and their expression and methylation were preliminarily verified. The results provide a new perspective for epigenetic and transcriptomic studies of A. japonicus response to heat stress, and provide a reference for breeding sea cucumbers resistant to high temperatures.

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Section: Discussionmentioning

confidence: 99%

Genome-wide DNA methylation and transcription analysis reveal the potential epigenetic mechanism of heat stress response in the sea cucumber Apostichopus japonicus

Chang

Liao

et al. 2023

Front. Mar. Sci.

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“…BDNF methylation was increased in the PFC of METH-addicted rats and patients but was decreased in the hippocampus of rats [131]. The neurotoxic effects of METH exposure were partly caused by a decrease in BDNF expression [131,132]. According to a report by Moszczynska et al, METH induction leads to impaired cognition and memory, accompanied by an increase in long-interspersed element-1 (LINE-1) activity in both the dentate gyrus of the hippocampus (Hip) and the dorsum striatum (DS) [133].…”

Section: Dna Methylationmentioning

confidence: 91%

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Filošević Vujnović,

Stanković Matić,

Saftić Martinović

et al. 2024

Future Pharmacology

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Addiction is a complex brain disease influenced by genetic, environmental, and neurological factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in different brain regions, with a focus on the neurons responsible for rewarding effects in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Known markers for psychostimulant-induced neuronal plasticity in combination with droplet-based high-throughput single-cell sequencing divided the heterogeneity of cell populations in NAc and VTA into clusters, where all cells of the same type do not respond equally to exposure to psychostimulants. To explain psychostimulant-induced neuronal plasticity as changes in the amplitude and phase shifts of gene expression, we focused on epigenetic mechanisms of DNA and chromatin modifications, as well as DNA accessibility. We also comment on epitranscriptomics as a novel approach in the study of messenger RNA posttranslational modification, which regulates translation and potentially localized transcription in synapses in order to address the molecular chains that connect addiction from changes in gene expression to synaptic and, finally, neuronal plasticity.

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“…Altered BDNF promoter IV methylation in HD is not restricted to neurons in affected neuroanatomical structures, but it is also observed in non-neural cell types and may contribute to alter peripheral pools of BDNF to exacerbate the central loss of this neurotrophin [ 94 , 181 ]. Several intriguing reports assessing epigenetic endpoints in serum or post-mortem samples from humans suffering from other neurological and psychiatric disorders also observed the differential methylation of BDNF promoters [ 182 , 183 , 184 ]. The precise mechanisms by which DNMTs are inappropriately routed to specific promoters in HD are still unclear and require further investigation.…”

Section: Mechanisms Of Bdnf Gene Regulation In Hdmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Dysregulation as an Essential Pathological Feature in Huntington’s Disease: Mechanisms and Potential Therapeutics

2023

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Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption is well established to have numerous intersections with the pathogenesis of progressive neurological disorders. There is perhaps no greater example of disease pathogenesis resulting from the dysregulation of BDNF signaling than Huntington’s disease (HD)—an inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive impairments associated with basal ganglia dysfunction and the ultimate death of striatal projection neurons. Investigation of the collection of mechanisms leading to BDNF loss in HD highlights this neurotrophin’s importance to neuronal viability and calls attention to opportunities for therapeutic interventions. Using electronic database searches of existing and forthcoming research, we constructed a literature review with the overarching goal of exploring the diverse set of molecular events that trigger BDNF dysregulation within HD. We highlighted research that investigated these major mechanisms in preclinical models of HD and connected these studies to those evaluating similar endpoints in human HD subjects. We also included a special focus on the growing body of literature detailing key transcriptomic and epigenetic alterations that affect BDNF abundance in HD. Finally, we offer critical evaluation of proposed neurotrophin-directed therapies and assessed clinical trials seeking to correct BDNF expression in HD individuals.

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Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence

Cited by 15 publications

References 62 publications

Genome-wide DNA methylation and transcription analysis reveal the potential epigenetic mechanism of heat stress response in the sea cucumber Apostichopus japonicus

Genome-wide DNA methylation and transcription analysis reveal the potential epigenetic mechanism of heat stress response in the sea cucumber Apostichopus japonicus

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Brain-Derived Neurotrophic Factor Dysregulation as an Essential Pathological Feature in Huntington’s Disease: Mechanisms and Potential Therapeutics

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