Changes in water diuresis and vasopressin inactivation in mice fed on protein deficient diets

Some Studies of Posterior Pituitary and Adrenal Cortical Interrelationships in Patients With and Without Cirrhosis of the Liver 12

“…The fatty livers were capable of inactivating in vitro only one-third of the antidiuretic activity of an amount of pitressin which normal liver could completely destroy. These findings agree with those of Birnie, Blackmore, and Heller (14), who reported that a low protein diet greatly decreases the pitressin inactivating ability of the mouse liver in vitro.…”

The Influence of Environmental Temperature on the Level of Plasma Antidiuhetic Substances in the Rat

“…reduction of body weight occurred, with the smaller rise that followed heating when the experiment was repeated at the same temperature without loss of weight. Other workers have reported higher than normal ADS blood levels in animals and men fed protein deficient rations (Leslie and Ralli 1947;Schweppe and Freeman 1951;Guggenheim and Hegstead 1953), and in vitro studies would suggest (Birnie, Blackmore, and Heller 1952) that the protein-deficient liver destroys ADH less rapidly than the normal liver. Guggenheim has demonstrated that rats maintained on a thiaminedeficient diet exhibit a delayed diuretic response to a water load with impairment of ability of the liver to inactivate pitressin (Guggenheim 1954a), although the derangement of water metabolism in pyridoxine-and pantothenic acid-deficient rats appears to be related to interference with adrenocorticotrophic hormone production rather than to ADH accumulation in the body (Guggenheim 1954b).…”

Changes in the Adrenal and Pituitary Gland in Experimental Malnutrition

“…This suggests that disturbances in renal function may lead to changes in the urinary output of antidiuretic substances. Moreover, it has been shown by Birnie et al (1952) that liver homogenates of protein malnourished animals do not inactivate vaso¬ pressin in vitro as effectively as those of normal animals. If the function of the renal tubular cell is correspondingly impaired in malnutrition, increased antidiuretic activity would be expected in the urine.…”

“…In malnutri¬ tion diminished inactivation of vasopressin has been reported (Birnie, Blackmore & Heller, 1952).…”