Changes in Vitamin D Status After Surgery in Female Patients With Lumbar Spinal Stenosis and Its Clinical Significance

Kim, So Yeon; Yoon, Ji Young; Lee, Byung Ho; Jung, Hyun Hwan; Park, Moon Soo; Park, Jin Oh; Moon, Eun Su; Kim, Hak-Sun; Lee, Hwan Mo; Moon, Seong Hwan

doi:10.1097/brs.0b013e318268ff05

Cited by 38 publications

(48 citation statements)

References 21 publications

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“…Waikakul found that all nine patients in a group with failed back surgery syndrome had hypovitaminosis D (<30 ng/mL); other case reports of failed spine surgery found similar rates [42–45]. Kim et al studied female spinal fusion patients and found all 31 had hypovitaminosis D (<30 ng/mL) preoperatively [46]. The largest spinal fusion study to date (313 preoperative patients) revealed a hypovitaminosis D prevalence rate of 57% (<30 ng/mL); furthermore, 27% of patients had 25(OH)D concentrations less than 20 ng/mL [47].…”

Section: Prevalence Of Hypovitaminosis Dmentioning

confidence: 99%

“…However, clinical studies have demonstrated a high prevalence of hypovitaminosis D among whites [8, 9, 14, 16, 40, 46, 47, 51]. Recent orthopedic and spine studies comprised mainly of white patients had hypovitaminosis D prevalence rates greater than 40% [8, 9, 47].…”

Section: Risk Factors For Hypovitaminosis Dmentioning

confidence: 99%

“…Unfortunately, there is a dearth of vitamin D-related spine data, and only four articles have data from 30 or more patients [10, 46–48]. The limited number of spine studies include both spinal surgery patients and those without surgical intervention [10, 42–48].…”

Section: Vitamin D and Spine Patientsmentioning

confidence: 99%

“…Of the two spinal fusion studies with greater than 30 patients, one reported preoperative data only and the other pre- and postoperative data [46, 47]. As previously discussed, Stoker et al reported an association between vitamin D deficiency and pain and disability scores, as well as a high prevalence of hypovitaminosis D in a study of 313 patients [47].…”

Section: Vitamin D and Spine Patientsmentioning

confidence: 99%

“…As previously discussed, Stoker et al reported an association between vitamin D deficiency and pain and disability scores, as well as a high prevalence of hypovitaminosis D in a study of 313 patients [47]. The second article looked at 31 female spinal fusion patients and found all to have hypovitaminosis D preoperatively and 16% to be vitamin D sufficient 1-year postoperatively [46]. Vitamin D treatment was not part of this study, as the premise was that patients' 25(OH)D concentrations would increase postoperatively due to the increased mobility.…”

Section: Vitamin D and Spine Patientsmentioning

confidence: 99%

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Vitamin D Status and Spine Surgery Outcomes

Rodríguez¹,

Gromelski²

2013

ISRN Orthopedics

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There is a high prevalence of hypovitaminosis D in patients with back pain regardless of whether or not they require surgical intervention. Furthermore, the risk of hypovitaminosis D is not limited to individuals with traditional clinical risk factors. Vitamin D plays an essential role in bone formation, maintenance, and remodeling, as well as muscle function. Published data indicate that hypovitaminosis D could adversely affect bone formation and muscle function in multiple ways. The literature contains numerous reports of myopathy and/or musculoskeletal pain associated with hypovitaminosis D. In terms of spinal fusion outcomes, a patient may have a significant decrease in pain and the presence of de novo bone on an X-ray, yet their functional ability may remain severely limited. Hypovitaminosis D may be a contributing factor to the persistent postoperative pain experienced by these patients. Indeed, hypovitaminosis D is not asymptomatic, and symptoms can manifest themselves independent of the musculoskeletal pathological changes associated with conditions like osteomalacia. It appears that vitamin D status is routinely overlooked, and there is a need to raise awareness about its importance among all healthcare practitioners who treat spine patients.

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Section: Prevalence Of Hypovitaminosis Dmentioning

confidence: 99%

Section: Risk Factors For Hypovitaminosis Dmentioning

confidence: 99%

Section: Vitamin D and Spine Patientsmentioning

confidence: 99%

Section: Vitamin D and Spine Patientsmentioning

confidence: 99%

Section: Vitamin D and Spine Patientsmentioning

confidence: 99%

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Vitamin D Status and Spine Surgery Outcomes

Rodríguez¹,

Gromelski²

2013

ISRN Orthopedics

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Fabrication, Characterization and Therapeutic Evaluation of Fluoxetine‐Dextran Nanoparticles

et al. 2023

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In recent times conventional dosage forms face a number of challenges, i. e., adverse effects, low absorption of drugs, and delivery at the targeted sites for desired therapeutic effect. In the current study, dextran-fluoxetine nanoconjugates were prepared, characterized, and evaluated for therapeutic efficacy. Dextran was oxidized via aldehyde functional group subsequently conjugated with fluoxetine using Schiff based reaction. Characterization techniques like ultra-violet spectroscopy, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and circular dichroism spectroscopy confirmed successful drug-polymer conjugation. Nanoconjugates size and shape was assessed using dynamic light scattering and atomic force microscopy respectively, whereas thermo-gravimetric analysis revealed the stability. Drug loading was found 21 %, whereas the drug release for 48 h showed 28 % release at pH = 5 and 16 % at pH = 7.4. Anticancer activity of the nanoparticles was assessed using HeLa cell lines and revealed 99.5 % cellular inhibition whereas cytotoxic assay was done using healthy cell line 3T3 showing 14.6 % cell inhibition. This study showed controlled release of drugs from the nanoparticles in the simulated conditions and has potential to reduce associated adverse effects. It is hypothesized that these nanoparticles may find application in anticancer drugs-controlled release with reduced toxicities.

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Bone Metabolism

Anderson¹

2020

Handbook of Spine Technology

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Changes in Vitamin D Status After Surgery in Female Patients With Lumbar Spinal Stenosis and Its Clinical Significance

Abstract: Vitamin D deficiency was common in patients with LSS. However, vitamin D status was improved after decompressive surgery, and postoperative 25-OHD level was significantly correlated with surgical outcomes.

Cited by 38 publications

References 21 publications

Vitamin D Status and Spine Surgery Outcomes

Vitamin D Status and Spine Surgery Outcomes

Fabrication, Characterization and Therapeutic Evaluation of Fluoxetine‐Dextran Nanoparticles

Bone Metabolism

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