Changes in Total Body Calcium after Renal Transplantation: Effect of Low-Dose Steroid Regime

Eastell, Richard; Kennedy, Norman; Smith, M. A.; Tothill, P.; Anderton, J. L.

doi:10.1159/000183449

Cited by 11 publications

(1 citation statement)

References 5 publications

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“…Figure 1 shows the average values of BMD in studies of patients with CKD Stage 5D 4–6,12,13,16,29–76 . These values are expressed as Z ‐scores, which compare BMD in the patients with the BMD from the reference values of age‐ and gender‐matched persons in the community.…”

Section: Bone Density Measurements In Patients Receiving Haemodialysismentioning

confidence: 99%

Review article: Bone density in patients with chronic kidney disease stages 4‐5

Ott

2009

Nephrology

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SUMMARY:Skeletal fractures are common in dialysis patients. Bone density measurements predict fractures in the general population, but in patients with chronic kidney disease (CKD) there is limited ability to predict fractures with these techniques. A review of the literature in patients with CKD stage 5 shows that bone density in the cortical bone of the radius or hip is generally lower compared with normal reference ranges by about one to two standard deviations, whereas in the spine bone density tends to be closer to the average expected values. The bone density is not able to predict the underlying histology in patients with renal osteodystrophy. The serum PTH levels are inversely related to bone density in some studies, and not related in other studies, but none found a positive association of serum parathyroid hormone (PTH) and bone density. There are very few data about longitudinal changes of bone density in these patients, and also inadequate studies of whether osteoporosis medications are effective in this population. Therefore, at this time the clinical utility of bone density measurements in patients with CKD-5 is uncertain.

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Section: Bone Density Measurements In Patients Receiving Haemodialysismentioning

confidence: 99%

Review article: Bone density in patients with chronic kidney disease stages 4‐5

Ott

2009

Nephrology

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Rates of vertebral bone loss before and after liver transplantation in women with primary biliary cirrhosis

et al. 1991

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Atraumatic fractures caused by osteoporosis may be a serious complication of primary biliary cirrhosis. Mean (+/- S.D.) bone mineral density in the lumbar spine in 210 ambulatory women with primary biliary cirrhosis was 1.02 +/- 0.19 gm/cm2, 7% lower than that in 139 age-matched normal women (after adjustment for age and body weight) (p less than 0.001). Bone mineral density in the lumbar spine was inversely related to a risk score index of liver disease severity (r = -0.29, p less than 0.001). The mean rate of bone loss in 105 of these 210 women was 2%/yr +/- 4%/yr, twice as great as in the 139 normal women (p less than 0.02). In 20 women with primary biliary cirrhosis followed up after orthotopic liver transplantation, bone mineral density in the lumbar spine decreased at 3 mo (p less than 0.01), and this decrease may have resulted in atraumatic fractures in 13 of them. Bone mineral density in the lumbar spine then increased (p less than 0.01) so that by 12 mo the median bone mineral density in the lumbar spine was similar to that before transplantation and by 24 mo it was 5% above it. Therefore we conclude that the progressive bone loss observed in primary biliary cirrhosis (which is further accentuated immediately after transplantation) may be halted, and the bone mass may be restored toward normal within 2 to 3 yr after orthotopic liver transplantation.

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