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Single energy spectrum quantitative CT (SES-QCT) was applied for the assessment of the trabecular bone mineral status in patients under long-term corticosteroid treatment. Seventeen renal graft recipients (RGR) and 12 patients receiving corticosteroid treatment for collagen disease were studied. A reduction of about 40% in the spinal trabecular bone density relative to matched controls was found, associated with the corticosteroid administration. Repeated measurements showed significant reduction in density 4 months after transplantation, and an increase in density after graft rejection. Radiologic or clinical evidence of osteopenia in the spine was not found. Other non-invasive techniques, applied in the upper extremities of the RGR, showed only minor bone reduction compared to controls. The findings of the present study suggest that adipose tissue deposition in the spinal trabeculae can introduce errors in the measurements. Therefore, SES-QCT should not be applied during corticosteroid therapy.
Single energy spectrum quantitative CT (SES-QCT) was applied for the assessment of the trabecular bone mineral status in patients under long-term corticosteroid treatment. Seventeen renal graft recipients (RGR) and 12 patients receiving corticosteroid treatment for collagen disease were studied. A reduction of about 40% in the spinal trabecular bone density relative to matched controls was found, associated with the corticosteroid administration. Repeated measurements showed significant reduction in density 4 months after transplantation, and an increase in density after graft rejection. Radiologic or clinical evidence of osteopenia in the spine was not found. Other non-invasive techniques, applied in the upper extremities of the RGR, showed only minor bone reduction compared to controls. The findings of the present study suggest that adipose tissue deposition in the spinal trabeculae can introduce errors in the measurements. Therefore, SES-QCT should not be applied during corticosteroid therapy.
The aim of this study was to assess non-invasively the status of spinal trabecular bone in patients with chronic renal failure and the influence of the disease stage. Single energy quantitative computed tomography (CT) was used in 89 patients with chronic renal failure to measure spinal trabecular bone equivalent density. 23 patients were independent of dialysis and 66 were receiving long-term haemodialysis. Spinal trabecular bone density of the patients was compared with locally determined normal ranges. Although trabecular bone mineral density (BMD) was lower (9% on average) in the patients who were not dependent on dialysis compared with the predicted mean normal values (BMDp) for age- and sex-matched normal subjects, the difference was not statistically significant. A statistically significant reduction was found in patients on dialysis (BMD/BMDp 0.75 +/- 0.16, Z-score -1.3). Osteosclerosis was found in 11 patients and they were excluded from the study. Longitudinal measurements in 42 patients on dialysis without osteosclerosis showed a 2.9% mean reduction in BMD/BMDp over a period of 8 months. All but one of the 16 haemodialysis patients with osteopenic spinal fractures had trabecular BMD values lower than the fracture threshold determined by our technique. In conclusion, end-stage chronic renal failure was associated with reduction in the spinal trabecular bone density.
Single energy spectrum quantitative CT (SES-QCT) was applied for the assessment of the trabecular bone mineral status in patients under long-term corticosteroid treatment. Seventeen renal graft recipients (RGR) and 12 patients receiving corticosteroid treatment for collagen disease were studied. A reduction of about 40% in the spinal trabecular bone density relative to matched controls was found, associated with the corticosteroid administration. Repeated measurements showed significant reduction in density 4 months after transplantation, and an increase in density after graft rejection. Radiologic or clinical evidence of osteopenia in the spine was not found. Other noninvasive techniques, applied in the upper extremities of the RGR, showed only minor bone reduction compared to controls. The findings of the present study suggest that adipose tissue deposition in the spinal trabeculae can introduce errors in the measurements. Therefore, SES-QCT should not be applied during corticosteroid therapy. Key words:Spine; quantitative CT; corticosteroids; osteopenia.Osteopenia is a side effect of corticosteroid administration (16). The term "osteopenia" is used because of the multiple and not completely understood effects of corticosteroids on bone metabolism (1, 9). The influence of corticosteroid administration on spinal bone minerals has not been adequately studied with noninvasive techniques. The usefulness of CT for the assessment of bone mineral status in the spine lies in its ability to provide quantitative data on the vertebral trabecular bone (2, 4, 10, 14, 19). In the present study patients under long-term corticosteroid treatment were examined applying single energy spectrum quantitative CT (SES-QCT). Material and MethodsTwenty-nine patients receiving corticosteroid treatment, divided into 2 groups, were studied. Group A consisted of 12 females (aged 29-65 years, mean 49 years) who received corticosteroids for various collagen diseases (6 for systemic lupus erythematosus, 3 for mixed connective tissue disease, 3 for polyarteritis nodosa). Group B (15 males and 4 females) consisted of patients (aged 21-58 years, mean 42 years) who had undergone renal transplantation up to 17 years earlier (mean time 5.5 years). Among renal graft recipients (RGR) 4 were measured a few days before and 4 months after transplantation. Five RGR with graft rejection and subsequent hemodialysis were measured after withdrawal of the corticosteroid treatment. The rest of the patients were studied by single SES-QCT measurements. Whereas patients in Group A received high doses of corticosteroids (initial dose 50-60 mg/day prednisolone followed by about 20 mg/ day for at least 1 year), patients in Group B received low doses (up to 10 mg/day prednisolone).A modified version of the Cann-Genant single kVp QCT technique (2) was applied for the measurement of the electron density in spinal trabecular bone (19). The trabecular bone equivalent density (TBED) was expressed as the density of a K,HPO, solution that exhibits an identical linea...
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