Changes in the US Burden of Chronic Kidney Disease From 2002 to 2016

Bowe, Benjamin; Xie, Yan; Li, Tingting; Mokdad, Ali H.; Xian, Hong; Yan, Yan; Maddukuri, Geetha; Al‐Aly, Ziyad

doi:10.1001/jamanetworkopen.2018.4412

Cited by 112 publications

(89 citation statements)

References 31 publications

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“…In today's world, with demographic expansion and increased high risk behavior, probability of death from CKD among young adults is increasing. 23 Supporting the evidence, we observed the average of CKD cases studied was 25.6 years at presentation. With the lack of an updated registry system, the rising prevalence of CKD in young productive population gives a socioeconomic impact in developing countries like India.…”

Section: Discussionsupporting

confidence: 67%

Chronic kidney disease in pregnancy and fetomaternal outcome

Gupta

Chawla

Ara

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Chronic kidney disease is a heterogeneous group of renal dysfunctions with complex and varied presentations in pregnancy. With a long asymptomatic course, timely diagnosis and management is crucial for fetomaternal wellbeing.Methods: A retrospective cohort study over a period of 3 years and 4 months included all obstetric in patients with known or newly diagnosed renal disorders. Maternal outcome was measured with regard to biochemical parameters presence /absence of proteinuria, hypertension, mode of pregnancy termination and complications. Fetal outcome was noted with respect to antenatal complications, weight, Apgar, NICU stay. Computation of results was done using percentages, mean and proportions.Results: Out of 13 women studied, 53.8% were pre-diagnosed cases of renal dysfunction and 46.2% were diagnosed during pregnancy. 38% had proteinuria at first visit and 50% remained so even after delivery. 60% had history of pregnancy induced hypertension in their previous pregnancies. Secondary hypertension and superimposed preeclampsia were seen in 30% and 38% cases respectively, with only one patient requiring magnesium sulphate prophylaxis in post-partum. Cardiac dysfunction was found to be coexisting in 15.3% cases with pre-existing renal leision. Intrauterine growth restriction was seen in 61.5% cases Average fetal weight was 2. 26kg with 30% having NICU stay. 30.6% had preterm delivery. Mode of delivery was caesarean section in 46% cases.Conclusions: Pregnancy with CKD is a high-risk pregnancy with adverse fetomaternal outcomes. For optimal pregnancy outcomes, an expert multidisciplinary team is required. With limited studies in south Asian population, there needs to be an upgradation in registry system.

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Section: Discussionsupporting

confidence: 67%

Chronic kidney disease in pregnancy and fetomaternal outcome

Gupta

Chawla

Ara

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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“…The burden of CKD has risen since 1990 in high-income settings, and despite generally good access to primary health care in most developed countries, attributable to ongoing exposure to risk factors, population aging, and population growth. 13,47 Within developed countries, the burden of CKD is variable as is the distribution of predisposing risk factors, which tend to be more prevalent in more socioeconomically disadvantaged populations. 47,48 Risk factor distribution may also differ between men and women and tends to increase with age; therefore, local epidemiology is relevant in development of strategies to address local risk factor burdens.…”

Section: Mitigation Of Major Traditional Risk Factors For Ckdmentioning

confidence: 99%

“…13,47 Within developed countries, the burden of CKD is variable as is the distribution of predisposing risk factors, which tend to be more prevalent in more socioeconomically disadvantaged populations. 47,48 Risk factor distribution may also differ between men and women and tends to increase with age; therefore, local epidemiology is relevant in development of strategies to address local risk factor burdens. 49,50 In many regions, metabolic risk factors are the major drivers of CKD risk, 47,50 and indeed, diabetes remains the most common cause of CKD globally.…”

Section: Mitigation Of Major Traditional Risk Factors For Ckdmentioning

confidence: 99%

“…47,48 Risk factor distribution may also differ between men and women and tends to increase with age; therefore, local epidemiology is relevant in development of strategies to address local risk factor burdens. 49,50 In many regions, metabolic risk factors are the major drivers of CKD risk, 47,50 and indeed, diabetes remains the most common cause of CKD globally. 13 The contribution of hypertension to the burden of CKD in developed countries is more variable but remains significant.…”

Section: Mitigation Of Major Traditional Risk Factors For Ckdmentioning

confidence: 99%

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Preventing CKD in Developed Countries

Luyckx

Cherney

Bello

2020

Kidney International Reports

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Chronic kidney disease (CKD) is an important public health concern in developed countries because of both the number of people affected and the high cost of care when prevention strategies are not effectively implemented. Prevention should start at the governance level with the institution of multisectoral polices supporting sustainable development goals and ensuring safe and healthy environments. Primordial prevention of CKD can be achieved through implementation of measures to ensure healthy fetal (kidney) development. Public health strategies to prevent diabetes, hypertension, and obesity as risk factors for CKD are important. These approaches are cost-effective and reduce the overall noncommunicable disease burden. Strategies to prevent nontraditional CKD risk factors, including nephrotoxin exposure, kidney stones, infections, environmental exposures, and acute kidney injury (AKI), need to be tailored to local needs and epidemiology. Early diagnosis and treatment of CKD risk factors such as diabetes, obesity, and hypertension are key for primary prevention of CKD. CKD tends to occur more frequently and to progress more rapidly among indigenous, minority, and socioeconomically disadvantaged populations. Special attention is required to meet the CKD prevention needs of these populations. Effective secondary prevention of CKD relies on screening of individuals at risk to detect and treat CKD early, using established and emerging strategies. Within high-income countries, barriers to accessing effective CKD therapies must be recognized, and public health strategies must be developed to overcome these obstacles, including training and support at the primary care level to identify individuals at risk of CKD, and appropriately implement clinical practice guidelines.

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“…There is a sense of urgency, however, in view of a recent report that the national burden of CKD is increasing, specifically in younger adults (10). These disturbing data should prompt an effort to address contributing causes more comprehensively.…”

mentioning

confidence: 99%