Changes in the serum cartilage biomarker levels of healthy adults in response to an uphill walk

Abstract

RESUlTSBoth groups shared similar demographic characteristics and activity duration. At T2, the serum COMP level of the experimental group was significantly higher than that of the control group, but the serum HA level of the experimental group was significantly lower than that of the control group. No significant difference between the serum WF6 levels of the experimental and control groups was observed at T2. CONClUSIONIncreasing levels of serum COMP demonstrate articular cartilage susceptibility to the increasing load. An unsustainable, high serum COMP level and an undetectable change in WF6 level were considered to be a reversible physiological change of the cartilage. A change in serum HA level could be related to intensive physical activity and dynamic clearance rather than a change in cartilage structure.

Classification of patients with non‐alcoholic fatty liver disease using rapid immunoassay of serum type IV collagen compared with liver histology and other fibrosis markers

“…In addition, HA is also synthesized in synovial lining cells. Joint disease and exercise may have an impact on HA levels . In our study, HA was not correlated with Matteoni's classification, nor NAS.…”

Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults

“…In another study 26 , the same group found a load-induced increase in sCOMP of 32% and 30% after 100 drop landings or 30 min running in 14 healthy young subjects. Pruksakorn et al 27 observed no loadinduced increase in sCOMP after a 14 km level walk but a 25% increase after a 14 km uphill walk. However, the activities compared in these studies varied in several load characteristics.…”

Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

“…For instance, serum concentrations of cartilage oligomeric matrix protein (COMP) increase after exercise bouts of walking (Mündermann, Dyrby, Andriacchi, & King, 2005;Mündermann, King, Smith, & Andriacchi, 2009;Pruksakorn et al, 2013), running (Kersting, Stubendorff, Schmidt, & Bruggemann, 2005;Niehoff et al, 2010;Niehoff et al, 2011) and marathon running (Neidhart et al, 2000) but not after deep knee bends (Niehoff et al, 2010). Hence, load-induced changes in COMP appear to be sensitive to load magnitude.…”