Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

Mündermann, Annegret; Geurts, Jeroen; Hügle, Thomas; Nickel, Thomas; Schmidt‐Trucksäss, Arno; Halle, Martin; Hanssen, Henner

doi:10.1080/02640414.2016.1184301

Cited by 22 publications

(29 citation statements)

References 40 publications

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“…found an increase in COMP concentration in six healthy individuals after 30 min of running and also provided additional information suggesting that serum COMP following lower body exercise may largely be from the knee joint, since they found a significant inverse relation between synovial fluid and serum COMP concentrations after the exercise session . In a study involving 45 male runners, Mündermann et al . also reported a 39% increase in serum COMP levels during a marathon race and that values remained high 24 h after.…”

Section: Discussionmentioning

confidence: 88%

“…also reported a 39% increase in serum COMP levels during a marathon race and that values remained high 24 h after. Additionally, they found increased high‐sensitivity CRP levels after the marathon and suggested that the increase in COMP and high‐sensitivity CRP levels may indicate an inflammatory process in stress‐induced cartilage metabolism during recovery …”

Section: Discussionmentioning

confidence: 99%

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Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

et al. 2017

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Women with and without RA have similar changes in response to a RE session in levels of inflammation biomarkers, but not of cartilage breakdown. IL-10 and IL-1ra increased after the RE session, indicating that RE may have an acute anti-inflammatory effect. Additional studies are necessary to clarify if repeated RE sessions can have long-term anti-inflammatory effects and the possible clinical repercussions of this cartilage breakdown characteristic in response to exercise in RA patients.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

et al. 2017

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“…Hence, when comparing the effects of different ambulatory activities on load-induced increases in sCOMP, potentially associated kinematic parameters cannot be neglected. Moreover, the duration of activity may also influence the magnitude of loadinduced increases in sCOMP as observed in studies on prolonged running 24,30 . Firner et al 36 applied a different approach and investigated the effects of modulated external knee flexion moments on load-induced increase in sCOMP increase.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, previous studies examining the effect of different physical activities and exercise on cartilage biomarkers reported increased serum COMP (sCOMP) levels after the activity burst 19e29 . Specifically, serum concentration of cartilage oligomeric matrix protein (sCOMP) levels were distinctly higher during and after a marathon (up to 1.6-fold) or ultramarathon run (up to 3-fold) than before the marathon 22e24, 28,30 . Moreover, during 14-day and 21-day bedrest sCOMP levels were 15% and 20% lower than before bedrest 31,32 .…”

Section: Introductionmentioning

confidence: 99%

Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults

Herger

Vach

Liphardt

et al. 2019

Osteoarthritis and Cartilage

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The results of this study provide important evidence of a dose-response relationship between ambulatory load magnitude and load-induced changes in sCOMP. Our data suggests that in normal weight persons sCOMP levels are more sensitive to increased than to reduced load. The experimental framework presented here may form the basis for studying the relevance of the dose-response relationship between ambulatory load magnitude and load-induced changes in biomarkers involved in metabolism of healthy articular cartilage and after injury.

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“…Previous studies have shown that serum COMP levels are sensitive to the loading mode of physical activity and that, for instance, slow but deep knee bends do not affect COMP levels. Moreover, COMP levels remain elevated after intense and prolonged physical activities such as a marathon or ultramarathon . In situ experiments have shown that moderate cyclic tensile strain alters the extracellular matrix organization and composition .…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of serum concentration of cartilage biomarkers to 21‐days of bed rest

Liphardt

Mündermann

Andriacchi

et al. 2017

Journal Orthopaedic Research

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The objective of the study was to test the hypothesis that serum levels of cartilage oligomeric 2 matrix protein (COMP) would decrease and serum levels of tumor-necrosis factor alpha 3 (TNF-α) and selected matrix metalloproteinases (MMPs) would increase in response to bed 4 rest (BR) and that these changes are unaffected by the intake of potassium bicarbonate or 5 whey protein. Seven and 9 healthy male subjects participated in two 21-day 6° head down tilt 6 crossover BR-studies with nutrition interventions. Serum samples were taken before, during, 7and after BR and biomarker concentrations were measured using commercial enzyme-linked 8 immunosorbent assays. MMP-3 during BR was significantly lower than at baseline (reduction 9 greater 20%; P<0.001). MMP-3 increased significantly from 14 to 21 days of BR (+7%; 10 P=0.049). COMP during BR was significantly lower than at baseline (reduction greater 20%; 11 P<0.001). MMP-3 and COMP returned to baseline within one day after BR. MMP-9 on day 3 12 of BR was significantly lower than at baseline (-31%; P<0.033) and on days 3, 5 and 14 of 13

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Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers

Cited by 22 publications

References 40 publications

Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

Acute effect of a resistance exercise session on markers of cartilage breakdown and inflammation in women with rheumatoid arthritis

Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults

Sensitivity of serum concentration of cartilage biomarkers to 21‐days of bed rest

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