Changes in the rates and population structure of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections: A single-centre experience (2000–2015)

Nikolaras, Georgios P.; Papaparaskevas, Joseph; Samarkos, Michael; Tzouvelekis, L. S.; Psychogiou, Mina; Pavlopoulou, Ioanna; Goukos, Demetrios; Polonyfi, Katerina; Pantazatou, Aggeliki; Deliolanis, Ioannis; Smilakou, Stavroula; Daikos, George L.

doi:10.1016/j.jgar.2018.11.023

Cited by 14 publications

(11 citation statements)

References 30 publications

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“…STs suffering considerable fitness cost upon developing high-level resistance to fluoroquinolones will be replaced by STs retaining much fitness even at high MIC values in "high fluoroquinoloneconsumption areas". In line with experimental results long dominant HA-MRSA clones, especially ST30, ST8, and ST239, have been losing ground to or have been completely replaced by CC5, ST228, and ST22 strains in adult hospital wards across various continents (Mato et al, 2004;Pérez-Roth et al, 2004;Velazquez-Meza et al, 2004;Ma et al, 2006;Amorim et al, 2007;Conceição et al, 2007;Aires-de-Sousa et al, 2008;Knight et al, 2012;Espadinha et al, 2013;Lim et al, 2013;Coombs et al, 2014;Abdulgader et al, 2015;Hsu et al, 2015;Lawes et al, 2015;Zarfel et al, 2016;Chamon et al, 2017;Nikolaras et al, 2018).…”

Section: Ha-mrsasupporting

confidence: 70%

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

2020

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Section: Ha-mrsasupporting

confidence: 70%

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

2020

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“…However, shifts may be occurring in the molecular epidemiology of S. aureus and MRSA among patients with bloodstream infections. As reported from a single-center surveillance in Greece, the widespread HA-MRSA clone ST239-III gradually decreased with the increase of the isolation frequency of these two CCs: HA-MRSA CC5, mostly belonging to ST5-II; and community-associated MRSA (CA-MRSA) CC80, mainly represented by ST80-IV-t044 19 . In this study, CC5-II MRSA was found in 34 isolates accounting for 91.9% (34/37) among CC5 MRSA isolates, suggesting that CC5 MRSA or CC5-II MRSA might be more frequent occurring among patients with MRSA BSIs in Shanghai.…”

Section: Discussionmentioning

confidence: 63%

“…The exact reasons for this specific decline among MRSA BSIs are not fully understood. However, in despite of these positive developments, S. aureus or MRSA still remains a priority for public health in Europe, with 10 of 30 countries reporting prevalence rates of MRSA > 25%, including Greece 19 .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018

Xiao

et al. 2020

Sci Rep

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Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is an important issue associated with significant morbidity and mortality and well known as a predominant pathogen causing bloodstream infection (BSis) globally. to estimate the antibiotic resistance and molecular characteristics of S. aureus causing BSIs in Shanghai, 120 S. aureus isolates (20 isolates each year) from the patients with S. aureus BSIs from 2013 to 2018 were randomly selected and enrolled in this study. Fifty-three (44.2%) MRSA isolates were determined, and no isolate was found resistant to vancomycin, daptomycin, synercid, linezolid and ceftaroline. The toxin genes tst, sec, seg and sei were found more frequently among MRSA isolates compared with MSSA isolates (all P < 0.0001). Twentynine sequence types (STs) were identified, and ST5 (23.3%) was the most common ST, followed by ST398 (11.7%) and ST764 (10.0%). SCCmec II (73.6%) was the most frequent SCCmec type among MRSA isolates. The dominant clonal complexes (CCs) were CC5 (ST5, ST764, ST965 and ST3066; 36.7%) and the livestock-associated clone CC398 (ST398, 11.7%). MRSA-CC5 was the predominant CC among MRSA isolates (37/53, 69.8%), and CC5-II MRSA was found in 34 isolates accounting for 91.9% (34/37) among CC5 MRSA isolates. In addition, all 29 tst-positive MRSA isolates were CC5-MRSA as well. Our study provided the properties and genotypes of S. aureus causing BSis at Ruijin Hospital in Shanghai from 2013 to 2018, and might suggest of value clues for the further study insights into pathogenic mechanisms intrinsically referring to the development of human-adapted S. aureus clones and their diffusions. Bloodstream infections (BSIs) is a severe infection with high incidence and lethality all over the world, and it always prolonged hospital stay for a long period 1. It has been reported to be one of the seven leading causes of death in North America and Europe 2. Staphylococcus aureus is well known as one of the most important human pathogens across the world and is capable of causing a variety of infections in healthcare facilities and communities. Furthermore, S. aureus is one of the major and most fatal causes of bacteremia with an estimated mortality of 20%, and at least 50% of patients with S. aureus bacteremia (SAB) will develop complicated bacteremia 3. S. aureus is one of the most common causes of severe BSIs with high morbidity and mortality. Early mortality associated with SAB appears to have plateaued at approximately 20-30% 4 , and imposes a substantial burden on patients and healthcare systems. In the United States, the annual incidence of SAB is 4.3 to 38.2 per 100,000 person-years, and the 30-day all-cause mortality of SAB is 20% and has not changed since the 1990s 5. In Ireland,

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“…Epidemiological studies of MRSA-ST80 PVL+ have revealed that these strains are primarily associated with recurrent, chronic, or particularly severe SSTIs, such as furuncles and abscesses [114]. This clone was also reported from other types of infections including fatal pneumonia and bloodstream infections [14,61,77,79]. In the study by Doudoulakakis et al, the authors reported that MRSA-ST80 PVL+ strains accounted for 95% of CA-MRSA pneumonia cases [14].…”

Section: Virulence Of Mrsa-st80mentioning

confidence: 97%

“…In the study by Doudoulakakis et al, the authors reported that MRSA-ST80 PVL+ strains accounted for 95% of CA-MRSA pneumonia cases [14]. Nikolaras et al showed that 8% of MRSA strains isolated from bloodstream infections were assigned to MRSA-ST80 clone [77]. In a collection of 94 MRSA-ST80 strains isolated in Lebanon and Jordan, 56% of these isolates were associated with SSTIs, 15% with respiratory tract infections, and 9% with bacteremia [115].…”

Section: Virulence Of Mrsa-st80mentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review

Mairi

Touati

Lavigne

2020

Toxins

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This review assessed the molecular characterization of the methicillin-resistant Staphylococcus aureus (MRSA)-ST80 clone with an emphasis on its proportion of total MRSA strains isolated, PVL production, spa-typing, antibiotic resistance, and virulence. A systematic review of the literature was conducted on MRSA-ST80 clone published between 1 January 2000 and 31 August 2019. Citations were chosen for a review of the full text if we found evidence that MRSA-ST80 clone was reported in the study. For each isolate, the country of isolation, the sampling period, the source of isolation (the type of infection, nasal swabs, or extra-human), the total number of MRSA strains isolated, number of MRSA-ST80 strains, antibiotic resistance patterns, PVL production, virulence genes, and spa type were recorded. The data from 103 articles were abstracted into an Excel database. Analysis of the data showed that the overall proportion of MRSA-ST80 has been decreasing in many countries in recent years. The majority of MRSA-ST80 were PVL positive with spa-type t044. Only six reports of MRSA-ST80 in extra-human niches were found. This review summarizes the rise of MRSA-ST80 and the evidence that suggests that it could be in decline in many countries.

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Changes in the rates and population structure of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections: A single-centre experience (2000–2015)

Cited by 14 publications

References 30 publications

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018

Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review

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