Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review

Abstract

This review assessed the molecular characterization of the methicillin-resistant Staphylococcus aureus (MRSA)-ST80 clone with an emphasis on its proportion of total MRSA strains isolated, PVL production, spa-typing, antibiotic resistance, and virulence. A systematic review of the literature was conducted on MRSA-ST80 clone published between 1 January 2000 and 31 August 2019. Citations were chosen for a review of the full text if we found evidence that MRSA-ST80 clone was reported in the study. For each isolate, the country of isolation, the sampling period, the source of isolation (the type of infection, nasal swabs, or extra-human), the total number of MRSA strains isolated, number of MRSA-ST80 strains, antibiotic resistance patterns, PVL production, virulence genes, and spa type were recorded. The data from 103 articles were abstracted into an Excel database. Analysis of the data showed that the overall proportion of MRSA-ST80 has been decreasing in many countries in recent years. The majority of MRSA-ST80 were PVL positive with spa-type t044. Only six reports of MRSA-ST80 in extra-human niches were found. This review summarizes the rise of MRSA-ST80 and the evidence that suggests that it could be in decline in many countries.

IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus

“…Skin and soft tissue infections (SSTI) caused by SA are of special significance worldwide due to their prevalence, the possibility of other disease complications and the associated costs (28,29). Skin infections typically include furuncles, carbuncles, impetigo, cellulitis, and skin abscesses (30), and methicillinresistant SA (MRSA) isolates have been found to play a major role in these infections, particularly clones such as USA100, USA300, ST-80, and USA1000 (31)(32)(33)(34). Toxins secreted by these and other strains of SA serve as key virulence factors in the pathogenesis of SA skin infections, specifically Hla (35), PVL (36,37) and SAgs (38,39).…”

Prevalence and Characterization of Methicillin-Resistant Staphylococcus aureus from Community- and Hospital-Associated Infections: A Tertiary Care Center Study

“…Since the first report of methicillin-resistant S. aureus (MRSA) in the 1960s, MRSA has been recognized as a pathogen of global concern [ 1 ]. Although MRSA infections were originally acquired only from hospital settings (HA-MRSA), community outbreaks were first reported in the 1990s from Australia and the United States of America, and subsequently from across the world [ 2 , 3 ]. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains were originally restricted to the community and found mainly in healthy, young patients [ 4 ].…”

Epidemiological and Clinical Evidence for the Role of Toxins in S. aureus Human Disease

“…The causal role of PVL in human disease has been debated due to its geographical stratification and low circulating presence in clinical strains outside of community-associated (CA-) MRSA. PVL is most closely associated with CA-MRSA strains (~85%) [ 28 ], including the highly virulent USA300, sequence type 8 (ST8) in the United States [ 29 ], as well as the dominant CA-MRSA clone in Europe, North Africa, and the Middle East, ST80 [ 30 ]. Outside of these CA-MRSA clones, the observed frequency at which pvl is observed is highly variable.…”