Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer

Makkonen, Tanja; Tenovuo, Jorma; Vilja, Pekka; Heimdahl, Anders

doi:10.1016/0030-4220(86)90007-1

Cited by 68 publications

(37 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides, studies show that systemic agents, such as pilocarpine, are more effective when used during radiotherapy. 34,40 This has also been recently showed for betanechol, when the drug used concomitantly with radiotherapy is able to increase salivary flow at rest, right after the end of the radiotherapy treatment, besides decreasing the subjective complaint of dry mouth. 41 …”

Section: Xerostomiamentioning

confidence: 69%

Complicações bucais da radioterapia em cabeça e pescoço

Jham

Freire

2006

Rev. Bras. Otorrinolaringol.

View full text Add to dashboard Cite

A radioterapia é uma forma terapêutica amplamente utilizada para o tratamento das neoplasias malignas da cabeça e pescoço. Porém, altas doses de radiação em extensos campos que irão incluir a cavidade bucal, maxila, mandíbula e glândulas salivares freqüentemente resultam em diversas reações indesejadas. Dentre as complicações da radioterapia estão a mucosite, candidose, disgeusia, cárie por radiação, osteorradionecrose, necrose do tecido mole e xerostomia. OBJETIVO: O objetivo deste artigo é fazer uma breve revisão das reações adversas que podem ser detectadas durante o tratamento radioterápico em região de cabeça e pescoço. MÉTODO: A literatura pertinente que trata do assunto foi revisada. FORMA DE ESTUDO: Revisão de literatura. RESULTADOS: A radioterapia ainda está associada a diversas reações adversas, que afetam de forma significativa a qualidade de vida dos pacientes. CONCLUSÕES: O tratamento multidisciplinar, incluindo a equipe médica, o cirurgião-dentista, o fonoaudiólogo, o nutricionista e o psicólogo é a melhor alternativa para minimizar ou mesmo prevenir tais complicações.

show abstract

Section: Xerostomiamentioning

confidence: 69%

Complicações bucais da radioterapia em cabeça e pescoço

Jham

Freire

2006

Rev. Bras. Otorrinolaringol.

View full text Add to dashboard Cite

show abstract

“…It is unlikely that albumin has anything to do with the caries process per se; rather this finding is a consequence of leakage of serum components (glucose, albumin) into saliva of diabetics. Albumin is normally present in saliva only in trace amounts [Oppenheim, 1970], but is increased in salivary gland disorders [Makkonen et al, 1986;Vesterinen et al, 2007], and thus parallels the elevated glucose in saliva.…”

Section: Discussionmentioning

confidence: 99%

Dental Caries Increments and Related Factors in Children with Type 1 Diabetes Mellitus

et al. 2008

View full text Add to dashboard Cite

The aim of this study was to analyse possible associations between caries increments and selected caries determinants in children with type 1 diabetes mellitus and their age- and sex-matched non-diabetic controls, over 2 years. A total of 63 (10–15 years old) diabetic and non-diabetic pairs were examined for dental caries, oral hygiene and salivary factors. Salivary flow rates, buffer effect, concentrations of mutans streptococci, lactobacilli, yeasts, total IgA and IgG, protein, albumin, amylase and glucose were analysed. Means of 2-year decayed/missing/filled surface (DMFS) increments were similar in diabetics and their controls. Over the study period, both unstimulated and stimulated salivary flow rates remained significantly lower in diabetic children compared to controls. No differences were observed in the counts of lactobacilli, mutans streptococci or yeast growth during follow-up, whereas salivary IgA, protein and glucose concentrations were higher in diabetics than in controls throughout the 2-year period. Multivariable linear regression analysis showed that children with higher 2-year DMFS increments were older at baseline and had higher salivary glucose concentrations than children with lower 2-year DMFS increments. Likewise, higher 2-year DMFS increments in diabetics versus controls were associated with greater increments in salivary glucose concentrations in diabetics. Higher increments in active caries lesions in diabetics versus controls were associated with greater increments of dental plaque and greater increments of salivary albumin. Our results suggest that, in addition to dental plaque as a common caries risk factor, diabetes-induced changes in salivary glucose and albumin concentrations are indicative of caries development among diabetics.

show abstract

“…They found signifi cantly reduced fraction of acidic proline-rich proteins compared with non-irradiated healthy subjects. On the other hand, Makkonen et al (1986) analyzed the radiation-induced changes in the fl ow rate and protein composition of stimulated whole saliva in eleven patients treated for malignant conditions of the head and neck. They observed unusually high salivary concentrations of albumin, lactoferrin, lysozyme, salivary peroxidase, myeloperoxidase, and total protein during the therapy, but most values slowly returned to pretreatment levels after cessation of radiation.…”

Section: Discussionmentioning

confidence: 99%

Altered Biochemical Parameters in the Saliva of Patients with Breast Cancer

Emekli-Alturfan

Demir

Kasikci

et al. 2008

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Saliva plays an important role in the protection of oral cavity and alterations in either salivary fl ow rate or protein composition may have dramatic effects on oral health. Prevention and management of oral complications of cancer and cancer therapy will improve oral function and quality of life, and reduce morbidity and the cost of care. The aim of this study was to investigate the saliva of patients with breast cancer biochemically and cytologically and compare with healthy controls. Accordingly, lipid peroxidation (LPO), total protein, salivary fl ow rate, and pH levels were measured in the saliva samples obtained from 20 breast cancer patients and 11 healthy individuals. Tissue factor (TF) is a major regulator of normal hemostasis and thrombosis, and TF activity of saliva samples was evaluated. Under the conditions used, patients with breast cancer present a signifi cant reduction in total protein, pH and LPO levels. Salivary TF activity was higher in breast cancer patients than that in control subjects, but the degree of increase was not statistically signifi cant. In addition, the analysis of saliva samples by SDS polyacrylamide gel electrophoresis showed the retarded mobility of the 66-kDa proteins and the increased proteins of about 36 kDa in the patient group. Some patients with breast cancer had increased number of leucocytes. Importantly, dysplastic cells and yeast cells were detected only in saliva samples of cancer patients. Decreased salivary LPO may be considered as a risk factor for breast cancer. breast cancer; saliva; tissue factor; lipid peroxidation; protein.Tohoku J. Exp. Med., 2008, 214 (2), 89-96.

show abstract

Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer

Cited by 68 publications

References 18 publications

Complicações bucais da radioterapia em cabeça e pescoço

Complicações bucais da radioterapia em cabeça e pescoço

Dental Caries Increments and Related Factors in Children with Type 1 Diabetes Mellitus

Altered Biochemical Parameters in the Saliva of Patients with Breast Cancer

Contact Info

Product

Resources

About