The article shows the results of researches of the natural zeolites influence on potato yield increase. It was found that the treated seed tubers and plants during the growing season with activated zeolite separately and in combination contributed to an increase in crop yield of 3.0-3.6%, when treated with an ultrafine analogue-by 4.3-12. 8% to the background. The marketability of potatoes in the variants where activated zeolite was used varied from 90.9 to 92.9%. When using ultrafine zeolite yield of commercial tubers was 92.9-97.1%. Ultrafine zeolite of particle sizes 80.0-350.0 nm was produced by ultrasonic action on activated zeolite (0.25-40.0 microns) at a frequency of 15.0 Hz (±10%). It was found that high biological activity of ultradispersed zeolite in comparison with actvated analog is caused by highly developed surface. In the process of dispersion of agglomerates and aggregates (associations of primary particles and crystallites) of actvated zeolite, a more developed specific surface of ultrafine zeolite is formed, which increases the number of active sites. Consequently, the processes of interaction between particles, including with a biological object, increase.