Changes in the prevalence of HIV‐associated mucosal disease at a dedicated clinic over 7 years

Greenwood, Ian; Zakrzewska, Joanna M; Pj, Robinson

doi:10.1034/j.1601-0825.2002.1o787.x

Cited by 39 publications

(44 citation statements)

References 14 publications

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“…[24][25][26] This low prevalence of lesions was confi rmed by the present study. Moreover, the combination therapy has shown to be effective in improving/restoring the quality of life and increasing survival rates of infected patients.…”

Section: Dmft Indexsupporting

confidence: 57%

“…Birnbaum et al, 24 Greenwood, Zakrzewska and Robinson, 26 Ferreira et al, 31 and Coogan, Greenspan and Challacombe 39 reported changes in the prevalence of oral mucosal lesions following the introduction of ART, including the reduction of the incidence of candidiasis, OHL and KS. A low prevalence of KS was also associated with the use of ART, as reported by Greenspan et al 25 In the present study, 68% of the patients used combination ART for a mean period of 45 months (SD: 37.5 months).…”

Section: Dmft Indexmentioning

confidence: 99%

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DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian region - Brazil

Aleixo¹,

Scherma²,

Guimarães³

et al. 2010

Braz J Infect Dis

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We declare no confl ict of interest. ABSTRACTWe evaluated the DMFT (decayed, missing and fi lled teeth) index and the prevalence of candidiasis, linear gingival erythema, oral hairy leukoplakia, herpes simplex, aphthous ulcers, Kaposi's sarcoma and lymphoma, as well as the association with TCD4 count, viral load (VL) and antiretroviral therapy (ART) in 140 HIV-infected adult individuals. A standardized examination to determine the DMFT index and the presence of oral lesions was conducted. Demographic data, TCD4 count and use of ART were obtained from medical records. A high number of decayed teeth detected among patients undergoing ART resulted in a mean DMFT of 16.9 teeth. It was observed that 24.2% of the individuals had at least one oral lesion. Candidiasis was the most frequent lesion and was associated with the TCD4 count. Oral hairy leukoplakia was associated with an increased VL. Regular use of ART was inversely associated with the occurrence of lesions. Overall, the studied population showed low prevalence of oral lesions and high DMFT index. The use of ART seems to reduce the occurrence of these lesions. Higher TCD4 count and a lower VL were associated with an improved oral health status in HIV+ individuals.

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Section: Dmft Indexsupporting

confidence: 57%

Section: Dmft Indexmentioning

confidence: 99%

DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian region - Brazil

Aleixo¹,

Scherma²,

Guimarães³

et al. 2010

Braz J Infect Dis

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“…In recent years, the emergence of human immunodeficiency virus infection and the frequent use of immunosuppressant therapy have led to a sharp increase in the incidence of oral infections caused primarily by Candida albicans (10,22,23).…”

Section: Increased Induction Of Interleukin 8 (Il-mentioning

confidence: 99%

Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression inCandida albicans-Infected Human Gingival Epithelial Cells

et al. 2005

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Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.

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“…The low proportions of oral manifestations in this study are likely to have been influenced by use of anti-retroviral treatment which has been made widely since 2004. Petersen (2006 and Greenwood et al, 2002 also emphasized that in most developed countries alike, the availability and consistent use of antiretroviral drugs had dramatic reduction effect on the HIV-related morbidity and mortality. Opportunistic conditions are greatly modified in the era of antiretroviral drugs and increased knowledge of combating the insurgence (Kaste et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…With the introduction and use of antiretroviral drugs, along with increasing knowledge on HIV and its commonly associated opportunistic infections, the trend of oral manifestations has been greatly modified (Greenwood et al, 2002;Kaste & Bednarsh, 2007;Kisangau et al, 2007). This is regardless the type of medication involved, whether by traditional healing or modern-western (Rudolph et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and awareness of oral manifestations among people living with HIV/AIDS attending counselling and treatment centres in Iringa Municipality, Tanzania

Mwangosi¹,

Majenge

2011

Tanzania J Hlth Res

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There is limited literature on the magnitude of oral manifestations and the extent of awareness on its occurrence in people living with HIV/AIDS (PLWHA) in Tanzania. The objective of this study was to assess the magnitude of, and extent of awareness on oral manifestations among PLWHA attending counselling and treatment centres (CTC) in Iringa Municipality in south-western Tanzania. A convenient sample of 200 PLWHA was included in the study in two CTC. Each participant was interviewed using a structured questionnaire. Thereafter a quick clinical oral assessment by a dentist was performed to record any relevant abnormality. The mean age of participants was 38.4 ±11.9 years. Females were 63.3% and most of the participants had primary education (53%). Generally, 23.5% of the PLWHAs had at least one oral manifestation, with statistical significant difference across age groups. Clinical manifestations observed were mucosal ulcerations with or without severe periodontal lesions (7.0%), angular chelitis (7.0%), oral thrush (6.5%), Kaposi's sarcoma (1.5%), and hairy leukoplakia (1.0%). The majority (89.5%) of the PLWHAs had sound awareness on clinical oral manifestations with significant statistical difference by educational status -the strength increased linearly with educational status. In general, 77.0% of the PLWHAs had healthy oral cavities. In conclusion, the prevalence and severity of clinical oral manifestations among PLWHA was low and the majority of PLWHA were aware of the conditions. However, it is recommended that more intensive studies should be carried out to assess the standard strength of the public awareness on oral manifestations among PLWHA and ascertain the magnitude of the problem and facilitate appropriate control strategies.

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Changes in the prevalence of HIV‐associated mucosal disease at a dedicated clinic over 7 years

Abstract: These data provide evidence that decreases in the prevalence of oral disease in people with HIV infection can be attributed to the effectiveness of ART.

Cited by 39 publications

References 14 publications

DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian region - Brazil

DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian region - Brazil

Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression inCandida albicans-Infected Human Gingival Epithelial Cells

Prevalence and awareness of oral manifestations among people living with HIV/AIDS attending counselling and treatment centres in Iringa Municipality, Tanzania

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