Changes in the pressure-volume relation of the right ventricle when its loading conditions are modified.

Redington, Andrew N.; Rigby, Michael L.; Shinebourne, E A; Oldershaw, Paul

doi:10.1136/hrt.63.1.45

Cited by 148 publications

(86 citation statements)

References 11 publications

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“…This confirms that the EM model was effectively calibrated and provided, for this patient, realistic motion patterns. Finally, despite our simple regurgitation model, the simulated pressure-volume (PV) loop was consistent with measurements in ToF reported in the literature [17] (this data was not available for this patient). …”

Section: Preoperative Simulationsupporting

confidence: 61%

Virtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model

Mansi

André

Lynch

et al. 2009

Recent Advances in the 3D Physiological Human

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Pulmonary valve replacement (PVR) is a pivotal treatment for patients who suffer from chronic pulmonary valve regurgitations. Two PVR techniques are becoming prevalent: a minimally invasive approach and an open-heart surgery with direct right ventricle volume reduction. However, there is no common agreement about the postoperative outcomes of these PVR techniques and choosing the right therapy for a specific patient remains a clinical challenge. We explore in this paper how image processing algorithms, electromechanical models of the heart and real-time surgical simulation platforms can be adapted and combined together to perform patient-specific simulations of these two PVR therapies. We propose a framework where 1) an electromechanical model of the heart is personalised from clinical MR images and used to simulate the effects of PVR upon the cardiac function; 2) volume reduction surgery is simulated in real-time by interactively cutting, moving and joining parts of the anatomical model. The framework is tested on a young patient. The results are promising and suggest that such advanced biomedical technologies may help in decision support and surgery planning for PVR.

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Section: Preoperative Simulationsupporting

confidence: 61%

Virtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model

Mansi

André

Lynch

et al. 2009

Recent Advances in the 3D Physiological Human

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“…It has been difficult to study the response of the RV to changes in loading conditions although it is clear that it is significantly different from that of the LV. 35 In children, the noninvasive quantitation of RV function has been particularly difficult because magnetic resonance imaging often requires general anesthesia and radionuclide studies are hindered by the need for sedation, limited resolution, and radiation exposure. [36][37][38] Our data support that the RV MPI is a sensitive tool to estimate MPAP in children with IPAH and to monitor response to therapy.…”

Section: Discussionmentioning

confidence: 99%

Use of Myocardial Performance Index in Pediatric Patients with Idiopathic Pulmonary Arterial Hypertension

Dyer

Pauliks

Das

et al. 2006

Journal of the American Society of Echocardiography

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“…Increasing impedance in pulmonary hypertension changes the shape of the RV pressure-volume loop so that Emax is closer to peak systolic pressure [13,14]. Examples of pressure-volume loops from two PAH patients are shown in figure 1.…”

Section: Systolic Function Of the Right Ventriclementioning

confidence: 99%

The right ventricle in pulmonary arterial hypertension

2014

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Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH, the right ventricle tends to remain adapted to afterload with increased contractility and little or no increase in right heart chamber dimensions. However, less than optimal right ventricular (RV)-arterial coupling may already cause a decreased aerobic exercise capacity by limiting maximum cardiac output. In more advanced stages, RV systolic function cannot remain matched to afterload and dilatation of the right heart chamber progressively develops. In addition, diastolic dysfunction occurs due to myocardial fibrosis and sarcomeric stiffening. All these changes lead to limitation of RV flow output, increased right-sided filling pressures and under-filling of the left ventricle, with eventual decrease in systemic blood pressure and altered systolic ventricular interaction. These pathophysiological changes account for exertional dyspnoea and systemic venous congestion typical of PAH. Complete evaluation of RV failure requires echocardiographic or magnetic resonance imaging, and right heart catheterisation measurements. Treatment of RV failure in PAH relies on: decreasing afterload with drugs targeting pulmonary circulation; fluid management to optimise ventricular diastolic interactions; and inotropic interventions to reverse cardiogenic shock. To date, there has been no report of the efficacy of drug treatments that specifically target the right ventricle. @ERSpublicationsThe compensatory adaptation of right ventricular structure and function is linked to symptoms and prognosis in PAH http://ow.ly/D5W9R

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Changes in the pressure-volume relation of the right ventricle when its loading conditions are modified.

Cited by 148 publications

References 11 publications

Virtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model

Virtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model

Use of Myocardial Performance Index in Pediatric Patients with Idiopathic Pulmonary Arterial Hypertension

The right ventricle in pulmonary arterial hypertension

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