Changes in the minute ventilation of rats exposed to different concentrations of cigarette smoke

Coggins, Christopher R. E.; Musy, C.; Ventrone, R.

doi:10.1016/0378-4274(82)90125-4

Cited by 9 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sprague-Dawley rats were chosen as the experimental animal because they have been used frequently in inhalation studies with complex mixtures, so there is a large amount of background data available in the scientific literature (e.g., Coggins et al, 1982aCoggins et al, , 1982b). The test system has been described in detail elsewhere .…”

Section: Experimental Animalsmentioning

confidence: 99%

Comparative Inhalation Study in Rats, Using a Second Prototype of a Cigarette that Heats Rather than Burns Tobacco

Coggins

Ayres

Mosberg

et al. 1989

Inhalation Toxicology

View full text Add to dashboard Cite

Sprague-Dawley rats were exposed nose-only for 1 h/day on weekdays for 13 weeks to the smoke from test and reference cigarettes. The test cigarette was a new prototype: the tobacco is heated rather than burned. The University of Kentucky lR4F cigarette was used as a reference. The exposures used were around 25% higher than those used in earlier studies, and for the test cigarette the resulting blood carboxyhemoglobin concentrations approached those associated with death (62 + %). The smoke from the reference cigarette produced substantial reductions in breathing frequency, whereas the smoke from the test cigarette did not. The availability of nicotine from test and reference cigarettes was very similar. The histopathology seen (mucus-secreting cells; nasal, laryngeal, and bronchial hyperplasia and squamous metaplasia, pulmonary macrophages) indicated that most of the changes observed in the reference animals were absent in the test animals. When changes were seen in the test groups (primarily in the larynx), they were substantially reduced when compared with the reference groups and were completely reversible.The authors thank

show abstract

Section: Experimental Animalsmentioning

confidence: 99%

Comparative Inhalation Study in Rats, Using a Second Prototype of a Cigarette that Heats Rather than Burns Tobacco

Coggins

Ayres

Mosberg

et al. 1989

Inhalation Toxicology

View full text Add to dashboard Cite

show abstract

“…Exposure to DEE did not affect any of these respiratory parameters. Respiratory depression is typically seen with cigarette smoke-exposed rodents (Coggins et al, 1982) and is generally attributed to a reflex to sensory irritation of the trigeminal nerve or of lung C-fibers (Bonham et al, 2001).…”

Section: Uptakementioning

confidence: 99%

Chronic Nose-only Inhalation Study in Rats, comparing Room-aged Sidestream Cigarette Smoke and Diesel Engine Exhaust

Stinn

Teredesai

Anskeit

et al. 2005

Inhalation Toxicology

View full text Add to dashboard Cite

Nose-only exposure of male and female Wistar rats to a surrogate for environmental tobacco smoke, termed room-aged sidestream smoke (RASS), to diesel engine exhaust (DEE), or to filtered, fresh air (sham) was performed 6 hours/day, 7 days/week for 2 years, followed by a 6-month post-exposure period. The particulate concentrations were 3 and 10 mg/m3. Markers of inflammation in bronchoalveolar lavage showed that DEE (but not RASS) produced a dose-related and persistent inflammatory response. Lung weights were increased markedly in the DEE (but not RASS) groups and did not decrease during the 6-month post-exposure period. Bulky lung DNA adducts increased in the RASS groups, but not in the DEE groups. Cell proliferation in the lungs was unaffected by either experimental treatment. Histopathological responses in the RASS groups were minimal and almost completely reversible; lung tumors were similar in number to those seen in the sham-exposed groups. Rats exposed to DEE showed a panoply of dose-related histopathological responses: largely irreversible and in some cases progressive. Malignant and multiple tumors were seen only in the DEE groups; after 30 months, the tumor incidence (predominantly bronchiolo-alveolar adenomas) was 2% in the sham-exposed groups, 5%in the high RASS groups, and 46% in the high DEE groups (sexes combined). Our results suggest that in rats exposed to DEE, but not to RASS, the following series of events occurs: particle deposition in lungs --> lung "overload" --> pulmonary inflammation --> tumorigenesis, without a significant modifying role of cell proliferation or DNA adduct formation.

show abstract

“…Most studies used the Federal Trade Commission (FTC)/International Standards Organisation (ISO) standard of 35-ml puffs of 2-s duration, taken once per minute (ISO 1991). A few studies included radiolabeled markers of deposition, because minute ventilation is known to be markedly affected by smoke (Coggins, Musy, and Ventrone 1982). Many studies used nose-only smoking machines (Baumgartner and Coggins 1980; Henry et al 1985), others used whole-body exposures with known disadvantages (Langård and Nordhagen 1980).…”

Section: Cigarettes Smoking Conditions Smoke Chemistrymentioning

confidence: 99%

An Updated Review of Inhalation Studies with Cigarette Smoke in Laboratory Animals

Coggins¹

2007

Int J Toxicol

View full text Add to dashboard Cite

Until recently, the published literature on inhalation studies with laboratory animals and cigarette smoke consisted entirely of negative findings, as far as neoplastic disease is concerned. This paper brings readers up to date, with analyses of recent studies that do indeed appear to report success after so many years of failure. The paper consists of a brief analysis of the literature up until a couple of years ago, giving brief, representative examples of inhalation studies with the five main species of laboratory animals that have been used: rat, mouse, hamster, dog, and nonhuman primate. A brief examination of the various technologies used to expose laboratory animals is given, along with an analysis of the histopathology and related toxicology data (specifically, biomarkers of exposure) that have been reported. The paper concludes by briefly mentioning the most recent studies, where positive results have been reported.

show abstract

Changes in the minute ventilation of rats exposed to different concentrations of cigarette smoke

Cited by 9 publications

References 9 publications

Comparative Inhalation Study in Rats, Using a Second Prototype of a Cigarette that Heats Rather than Burns Tobacco

Comparative Inhalation Study in Rats, Using a Second Prototype of a Cigarette that Heats Rather than Burns Tobacco

Chronic Nose-only Inhalation Study in Rats, comparing Room-aged Sidestream Cigarette Smoke and Diesel Engine Exhaust

An Updated Review of Inhalation Studies with Cigarette Smoke in Laboratory Animals

Contact Info

Product

Resources

About