Changes in the mannan binding lectin (MBL) concentration in human milk during lactation

Trégoat, Virginie; Montagne, P.; Béné, Marie‐Christine; Fauré, G

doi:10.1002/jcla.10055

Cited by 16 publications

(7 citation statements)

References 33 publications

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“…According to Kehrli et al (2009) and Goff (2008), decreased expression of this protein observed in the pre-and postpartum period could also be associated with short-term immune suppression, perinatal maternity stress, lower food intake, and high concentrations of glucocorticoids, as well as reduced levels of calcium. Lower expression of this protein in the first week after calving in the analyzed cows may be associated with secretion of the protein into colostrum and milk, which is consistent with the results reported by Trégoat et al (2002).…”

Section: Discussionsupporting

confidence: 91%

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Kurpińska

Jarosz²,

Ożgo³

et al. 2016

Turk J Biol

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details of feeding shown in Table 1). Blood, the material for analysis, was drawn from the external jugular vein and collected using sterile needles and tubes with anticoagulant (EDTA K 3). Collection of samples was performed at the following points: 30, 14, and 7 days before parturition and 1, 7, 14, 30, and 60 days after calving. Blood was collected each time from the same animals, and groups were formed according to the sampling date; thus, each experimental group consisted of 10 animals. The total number of samples was 80. Blood samples were centrifuged (3000 rpm, 4 ºC), and the resulting plasma samples were stored at-80 °C until analysis. The local ethics committee for experiments on animals in Szczecin approved the design of the experiment (resolution no.

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Section: Discussionsupporting

confidence: 91%

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Kurpińska

Jarosz²,

Ożgo³

et al. 2016

Turk J Biol

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“…The amount of Igs and LF in milk decreases over the first 3–4 months, while the amount of lysozyme increases ( 87 ). Tregoat et al ( 88 ) described declining amounts of mannan-binding lectin concentrations in transition from colostrum to mature milk. More recent published studies using proteomic analysis of human milk ( 16 , 64 , 89 ) continue to facilitate our understanding of the complex nature of human milk and its role related to immune function and intestinal development.…”

Section: Evolution Of Bioactive Factors In Human Milk Over Lactationmentioning

confidence: 99%

Innate Immunity and Breast Milk

2017

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Human milk is a dynamic source of nutrients and bioactive factors; unique in providing for the human infant’s optimal growth and development. The growing infant’s immune system has a number of developmental immune deficiencies placing the infant at increased risk of infection. This review focuses on how human milk directly contributes to the infant’s innate immunity. Remarkable new findings clarify the multifunctional nature of human milk bioactive components. New research techniques have expanded our understanding of the potential for human milk’s effect on the infant that will never be possible with milk formulas. Human milk microbiome directly shapes the infant’s intestinal microbiome, while the human milk oligosaccharides drive the growth of these microbes within the gut. New techniques such as genomics, metabolomics, proteomics, and glycomics are being used to describe this symbiotic relationship. An expanded role for antimicrobial proteins/peptides within human milk in innate immune protection is described. The unique milieu of enhanced immune protection with diminished inflammation results from a complex interaction of anti-inflammatory and antioxidative factors provided by human milk to the intestine. New data support the concept of mucosal-associated lymphoid tissue and its contribution to the cellular content of human milk. Human milk stem cells (hMSCs) have recently been discovered. Their direct role in the infant for repair and regeneration is being investigated. The existence of these hMSCs could prove to be an easily harvested source of multilineage stem cells for the study of cancer and tissue regeneration. As the infant’s gastrointestinal tract and immune system develop, there is a comparable transition in human milk over time to provide fewer immune factors and more calories and nutrients for growth. Each of these new findings opens the door to future studies of human milk and its effect on the innate immune system and the developing infant.

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“…However, MBL levels are largely dependent on MBL2 genetic polymorphisms, which are responsible for inter-individual variations of up to 10-fold on circulating MBL levels ( 40 , 41 ). Besides genetic variation, MBL levels may also vary significantly during lifetime ( 42 – 44 ).…”

Section: Lectin Pathway Of Complement Activationmentioning

confidence: 99%

The Lectin Pathway of Complement and Rheumatic Heart Disease

et al. 2015

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The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry. The effector components of innate immunity include epithelial barriers, phagocytes, and natural killer cells, as well as cytokines and the complement system. Complement plays an important role in the immediate response against microorganisms, including Streptococcus sp. The lectin pathway is one of three pathways by which the complement system can be activated. This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively. Upon binding to target molecules, MBL, CL-K1, and ficolins form complexes with MBL-associated serine proteases 1 and 2 (MASP-1 and MASP-2), which cleave C4 and C2 forming the C3 convertase (C4b2a). Subsequent activation of complement cascade leads to opsonization, phagocytosis, and lysis of target microorganisms through the formation of the membrane-attack complex. In addition, activation of complement may induce several inflammatory effects, such as expression of adhesion molecules, chemotaxis and activation of leukocytes, release of reactive oxygen species, and secretion of cytokines and chemokines. In this chapter, we review the general aspects of the structure, function, and genetic polymorphism of lectin-pathway components and discuss most recent understanding on the role of the lectin pathway in the predisposition and clinical progression of Rheumatic Fever.

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Changes in the mannan binding lectin (MBL) concentration in human milk during lactation

Cited by 16 publications

References 33 publications

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Analysis of protein expression changes in the blood plasma of cows during the last month before parturition and 2 months after calving

Innate Immunity and Breast Milk

The Lectin Pathway of Complement and Rheumatic Heart Disease

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