Changes in the Intestinal Flora of Mice Following Administration of Bacterial Endotoxins

Ushiba, Daizo; Sugiyama, Takiko; Nakano, Masayasu

doi:10.1111/j.1348-0421.1962.tb00240.x

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The work of Sanarelli in the 1920s also suggests that endotoxin-induced diarrhea was a possibility (30). There is very little in the literature regarding the effects of LPS on the gut until 1962, when a group ofJapanese workers showed that parenteral administration of LPS preparations to mice, led to proliferation ofgastrointestinal luminal bacteria (31). Subsequent work clearly established that this enhancement of bacterial growth was secondary to fluid exudation, since the bacterial growth could be suppressed by enteral administration of unabsorbable antibiotics like Neomycin (1 1).…”

Section: Discussionmentioning

confidence: 99%

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Mathan

Penny²,

Mathan³

et al. 1988

J. Clin. Invest.

View full text Add to dashboard Cite

Subcutaneous challenge of mice with lipopolysaccharide (LPS) from gram negative bacteria, produced an intestinal microvascular lesion causing fluid exudation into the lumen of the intestine and diarrhea. The microvascular lesion was characterized by endothelial cell damage and microthrombi in the venules and capillaries of the intestinal lamina propria. Marker organisms, given orally to challenged mice, grew in the exuded fluid and could invade the mucosa. Intravenous transfer of postchallenge plasma produced the lesion in normal mice and absorption of such plasma by Sepharose coupled to LPS-antibody abolished this effect. Instillation of large quantities of LPS into the lumen of the intestine produced scattered microvascular lesions, although none of these animals developed diarrhea. Since a similar microvascular lesion has been described in the rectal mucosal lamina propria of adults with acute diarrhea, it is suggested that LPS-induced vascular damage may be a novel mechanism in the pathogenesis of acute diarrhea.

show abstract

Section: Discussionmentioning

confidence: 99%

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Mathan

Penny²,

Mathan³

et al. 1988

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…There is little information on the role of intestinal CD14 and its interaction with LPS during acute bacterial diarrhea. A study conducted in the 1960s first demonstrated that parenteral administration of LPS in mice resulted in proliferation of bacteria in the intestinal lumen [35]. Subsequent work demonstrated that this effect was due to the availability of fluid that exuded into the gut lumen [36], likely to provide additional nutrients.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in the Promoter of the Gene Encoding the Lipopolysaccharide Receptor CD14 Are Associated With Bacterial Diarrhea in US and Canadian Travelers to Mexico

Mohamed¹,

DuPont²,

Flores³

et al. 2011

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

Changes in the Intestinal Flora of Mice Following Administration of Bacterial Endotoxins

Cited by 2 publications

References 11 publications

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Single Nucleotide Polymorphisms in the Promoter of the Gene Encoding the Lipopolysaccharide Receptor CD14 Are Associated With Bacterial Diarrhea in US and Canadian Travelers to Mexico

Contact Info

Product

Resources

About