Changes in the functional organization of the respiratory system in residents of Western Siberia in the winter season

Shishkin, G. S.; Ustyuzhaninova, N. V.; Gultyaeva, V. V.

doi:10.1134/s0362119714010149

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…However, there are observations that residents of the Northern regions have signs of increased bronchial resistance in winter as a result of exposure to frosty air. 49 Moreover, in summer in Europe and Siberia, the relative humidity is lower than in winter. It is known that high air humidity increases the effect of low atmospheric pressure on ρO 2 (Mendeleev–Сlapeyron equation).…”

Section: Discussionmentioning

confidence: 99%

Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis

Kuzmenko

Galagudza

2021

International Journal of Stroke

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Background Cardiovascular events (CVEs) occur more often in winter than in summer; however, the dependence of strokes on various meteorological factors remains unclear . Aims The purpose of this meta-analysis was to determine the dependence of the circannual dynamics of hospitalizations for hemorrhagic stroke (HS) and ischemic stroke (IS) on seasonal fluctuations in meteorological factors. Summary of review and conclusions For our meta-analysis, we selected 20 and 26 publications examining the seasonal dynamics of HS and IS, respectively . The meta-analysis showed that HS occurs more often in winter than in other seasons and does not depend on a regionâs climate. The seasonal dynamics of IS are not clearly expressed and are determined by the characteristics of a regionâs climate. In a climate without pronounced seasonal dynamics of atmospheric pressure and in wet winters, the vector of IS incidents will not be expressed or slightly shifted toward winter. Low atmospheric pressure in summer is associated with an increased likelihood of IS during this season compared to winter. There was also a relation between IS risk with high relative humidity and a significant decrease in ÏO2 in summer, but there is not enough evidence regarding this association. We did not reveal dependence of the seasonal dynamics of strokes on the amplitude of annual fluctuations in air temperature. Keywords: ischemic stroke, hemorrhagic stroke, season, meteorological factors, climate

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Section: Discussionmentioning

confidence: 99%

Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis

Kuzmenko

Galagudza

2021

International Journal of Stroke

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A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments

2017

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BackgroundMany mammals are well adapted to surviving in extremely cold environments. These species have likely accumulated genetic changes that help them efficiently cope with low temperatures. It is not known whether the same genes related to cold adaptation in one species would be under selection in another species. The aims of this study therefore were: to create a compendium of mammalian genes related to adaptations to a low temperature environment; to identify genes related to cold tolerance that have been subjected to independent positive selection in several species; to determine promising candidate genes/pathways/organs for further empirical research on cold adaptation in mammals.ResultsAfter a search for publications containing keywords: “whole genome”, “transcriptome or exome sequencing data”, and “genome-wide genotyping array data” authors looked for information related to genetic signatures ascribable to positive selection in Arctic or Antarctic mammalian species. Publications related to Human, Arctic fox, Yakut horse, Mammoth, Polar bear, and Minke whale were chosen. The compendium of genes that potentially underwent positive selection in >1 of these six species consisted of 416 genes. Twelve of them showed traces of positive selection in three species. Gene ontology term enrichment analysis of 416 genes from the compendium has revealed 13 terms relevant to the scope of this study. We found that enriched terms were relevant to three major groups: terms associated with collagen proteins and the extracellular matrix; terms associated with the anatomy and physiology of cilium; terms associated with docking. We further revealed that genes from compendium were over-represented in the lists of genes expressed in the lung and liver.ConclusionsA compendium combining mammalian genes involved in adaptation to cold environment was designed, based on the intersection of positively selected genes from six Arctic and Antarctic species. The compendium contained 416 genes that have been positively selected in at least two species. However, we did not reveal any positively selected genes that would be related to cold adaptation in all species from our list. But, our work points to several strong candidate genes involved in mechanisms and biochemical pathways related to cold adaptation response in different species.Electronic supplementary materialThe online version of this article (10.1186/s12863-017-0580-9) contains supplementary material, which is available to authorized users.

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The Influence of Climate on the Respiratory Function of the Healthy Population of Vladivostok and Patients With Bronchopulmonary Pathology

Веремчук

Mineeva

Виткина

et al. 2018

HAS

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Introduction. The climatic factors affect the mucous membrane of the respiratory tract contacting with the environment. The investigation of pulmonary ventilation plays a leading role in the diagnosis of bronchial obstruction in response to an external stimulus. Material and methods. The study included a healthy population of the city and patients with chronic catarrhal nonobstructive bronchitis (CCNB), controlled and uncontrolled asthma (131 people). The respiratory function (RF) was estimated by spirography and body plethysmography. Meteorological conditions were evaluated from the point of view of contrasting weather changes (on the survey day, on 1st and 2nd days before the survey). The degree of the climatic impact on RF was determined by the statistical module “Discriminant analysis”, used to a group of RF indices relatively adverse levels of impact of the monsoon climate. Results. The low level of the responsiveness in a healthy urban population was identified. The negative impact of climatic indices on the respiratory system in CCNB patients was observed mainly in extreme weather conditions. The influence of climatic conditions on patients with asthma depends on the level of the disease control. Discussion. The influence of climatic conditions was found to be within the adaptive and compensatory responses in a group of healthy people and CCNB patients. We assumed the use of basic drugs in patients with asthma without signs of bronchial obstruction to reduce the susceptibility of the receptors of the bronchi to the negative climatic impact. The greatest negative RF response to the impact of monsoon climate manifested both in static and in dynamic weather conditions, was observed in patients with uncontrolled asthma. It was associated with the impaired pulmonary ventilation. Conclusion. The results indicate the Far East monsoon climate to be an important risk factor for the exacerbation in patients with respiratory diseases.

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Changes in the functional organization of the respiratory system in residents of Western Siberia in the winter season

Cited by 3 publications

References 4 publications

Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis

Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis

A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments

The Influence of Climate on the Respiratory Function of the Healthy Population of Vladivostok and Patients With Bronchopulmonary Pathology

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