Changes in the Form of the Jaws of the Albino Mouse During Ontogeny

Wa, Gaunt

doi:10.1159/000142574

Cited by 3 publications

(3 citation statements)

References 4 publications

(9 reference statements)

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“…The upper and lower jaws grow differentially during prenatal development, from ED13 to ED18 . A rapid growth of the mandible has been observed during the formation of the secondary palate (ED13.5–15.0) .…”

Section: Positioning Of Teeth During Developmentmentioning

confidence: 99%

Three‐dimensional analysis of molar development in the mouse from the cap to bell stage

Lesot

Hovořáková

Peterka

et al. 2014

Australian Dental Journal

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During four days of prenatal development in the mouse, the morphology of the first lower molar moves from the early cap to the bell stage. Five phenomena characterize this period: growth of the tooth germ; development of the cervical loop; histogenesis of the enamel organ; folding of the epithelial-mesenchymal junction associated with cusp formation; and change in cellular heterogeneity in the mesenchyme. All these processes are controlled by epithelial-mesenchymal interactions. These complex histo-morphogenetic events have been documented using histological sections and 3D reconstructions. When combined with functional tests in vitro, this approach allowed searching for possible relationships between simultaneous changes occurring in both the epithelial and ecto-mesenchymal compartments. Parallel changes that occur in the two tissues could result from different mechanisms, as illustrated by the increasing number of pre-odontoblasts and pre-ameloblasts during crown growth. Cell division was involved mainly in the ectomesenchyme, while proliferation and cell re-organization occurred in the inner dental epithelium. 3D reconstructions also raised still unsolved questions, such as the possible relationship between cusp size and spatial specification of cell kinetic parameters, changes in cell position within the inner dental epithelium, and tracing cell migration in the mesenchyme during development.Keywords: Tooth development, mouse, molar, histo-morphogenesis, cytodifferentiation.Abbreviations and acronyms: BM = basement membrane; CL = cervical loop; ED = embryonic day; EFA = enamel free area; IDE = inner dental epithelium; PEK = primary enamel knot; OMU = Organizers of the Morphogenetic Units; PN = post-natal; SEK = secondary enamel knots; Shh = Sonic hedgehog; SI = stratum intermedium.

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Section: Positioning Of Teeth During Developmentmentioning

confidence: 99%

Three‐dimensional analysis of molar development in the mouse from the cap to bell stage

Lesot

Hovořáková

Peterka

et al. 2014

Australian Dental Journal

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“…Changes in the relative positions of teeth might be expected to result from specific growth parameters of individual teeth themselves (1) and from jaw development (2, 3). In fact, molar positioning results from the integration of both processes, and highly coordinated changes in the relative position of upper and lower molars in the mouse are concomitant with changes in the size and shape of jaws (3–6). Abnormalities or alterations in these different steps, if not compensated, might result in malocclusion (7, 8).…”

mentioning

confidence: 99%

Asymmetrical morphogenesis and medio‐lateral positioning of molars during mouse development

Cam¹,

Fausser²,

Vonesch³

et al. 2002

European J Oral Sciences

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The functionality of the dentition depends on occlusal relationships between opposing crown surfaces. To investigate the relative changes in positioning of upper and lower molar germs during mouse development, we used serial histological sections of late day 13 (embryonic day (ED)13.5) to early day 18 (ED18) foetus heads and performed computer-aided 3D reconstructions. From ED13.5 to ED15.5. the first lower molar (M1) got a less medial position relative to its upper counterpart (M1); superimposition progressed postero-anteriorly. From ED14.5, the apparent medial displacement of M(1) vs. M1 was partly due to the asymmetrical growth of the M(1) to give rise to the lingual row of cusps, conspicuous at ED17. The superimposition of M(2)/M2 along the medio-lateral axis was observed from their bud stage (ED14.5), and the one of M(1)/M1 was almost complete at ED15.5. However, this was not the final position. as at ED 18, M1 and M2 had a more lateral location than their upper counterparts. Immunostaining showed that differential expression of antigens associated to desmosomes but not to adherens junctions might be involved in the asymmetrical development of M(1) thus contributing to the relative medio-lateral positioning of the first molars at early stages.

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“…The tilting of the teeth tow ards or away from the sagittal head plane is an additional com plication and it appears from the sections that unequal bone developm ent on opposite sides of the tooth makes a substantial contribution to this tilting. This has been shown to occur also in the mouse (Gaunt [1964|) and ham ster (G a u n t [19611). The consensus of the factors ju st discussed are in complete agreem ent with the account of A l d r id g e [1962] where she describes and figures the dentition of H.beatus as moving forwards along a helical plane.…”

mentioning

confidence: 99%

Changes in the Form of the Jaws of the Albino Mouse During Ontogeny

Cited by 3 publications

References 4 publications

Three‐dimensional analysis of molar development in the mouse from the cap to bell stage

Three‐dimensional analysis of molar development in the mouse from the cap to bell stage

Asymmetrical morphogenesis and medio‐lateral positioning of molars during mouse development

Observations upon the developing dentition of <i>Hipposideros caffe</i><i>r</i> (<i>Microchiropter</i><i>a</i>)

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