Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy

Tanimura, Kenji; Nakago, Satoshi; Murakoshi, Homare; Takekida, Shigeki; Moriyama, Tohru; Matsuo, Hiroya; Hashimoto, Kimio; Maruo, Takeshi

doi:10.1530/eje.0.1510093

Cited by 12 publications

(16 citation statements)

References 42 publications

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“…Strong staining for HBEGF is observed in villous and extravillous trophoblast cells in both normal placentas and those delivered preterm (Leach et al, 1999, Leach et al, 2002. Other EGF family members and ERBB receptor tyrosine kinases are expressed in placental trophoblast populations (Hofmann et al, 1992, Tanimura et al, 2004, indicating that the EGF signaling system is highly active during placental development.…”

Section: Human Placentationmentioning

confidence: 99%

Cell signaling in trophoblast-uterine communication

Fritz¹,

Jain²,

Armant³

2014

Int. J. Dev. Biol.

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Intricate and precise communication between the blastocyst and the uterus orchestrates embryo implantation. However, many questions remain unanswered regarding the molecular complexities of implantation. On-time implantation requires a receptive uterus and a mature blastocyst with trophoblast cells capable of adhering to and invading the endometrium. Defects in uterine receptivity or embryo/uterine signaling can cause implantation failure or early pregnancy loss, whereas deficient trophoblast differentiation can generate placental abnormalities that produce adverse pregnancy outcomes. This review will discuss several examples of signaling pathways that regulate trophoblast and uterine development during this period. Leukemia inhibitory factor is involved in uterine priming for implantation. The epidermal growth factor signaling system contributes to trophoblast-uterine communication, as well as trophoblast adhesion and invasion. Indian hedgehog signaling synchronizes tissue compartments within the uterus, and WNT signaling mediates numerous interactions within the implantation site and developing placenta. The autocrine, paracrine and juxtacrine interactions mediated by these signaling pathways contribute significantly to the establishment of pregnancy, although there are many other known and yet to be discovered factors that synchronize the maternal and embryonic developmental programs.

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Section: Human Placentationmentioning

confidence: 99%

Cell signaling in trophoblast-uterine communication

Fritz¹,

Jain²,

Armant³

2014

Int. J. Dev. Biol.

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“…HBEGF is also expressed in villous and extravillous cytotrophoblast (CTB) from weeks 14–35 in normal placentas and those delivered preterm (Leach et al, 1999, 2002). Several members of the EGF family and HER tyrosine kinases are expressed in placental trophoblast populations (Hofmann et al, 1992; Tanimura et al, 2004), indicating that the EGF signaling system is active during placental development.…”

Section: The Role Of Hbegf In Human Placentationmentioning

confidence: 99%

Diverse functions of HBEGF during pregnancy

Jessmon

Leach

Armant

2009

Molecular Reproduction Devel

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SUMMARYThe establishment of pregnancy requires an intimate physical interaction and a molecular dialogue between the conceptus and the maternal reproductive tract that commences at implantation and continues until the placenta is formed and fully functional. Failure of the regulatory processes that ensure the fidelity of this relationship can precipitate a catastrophic pregnancy loss. One of the earliest identified molecular mediators of blastocyst implantation is heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF), which signals between the endometrium and implanting trophoblast cells to synchronize their corresponding developmental programs. HBEGF expression by trophoblast cells of the developing placenta appears to regulate extravillous differentiation and provide cytoprotection in a sometimes-hostile environment. This versatile member of the EGF signaling system will be examined in light of its associations with key events during early pregnancy.

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“…Acromegalic cardiomyopathy can be divided into three main stages [22, 89]. The early stage is characterized by functional abnormalities: enhanced myocardial contractility, decreased peripheral vascular resistance and increased cardiac output (hyperkinetic state) [22, 89, 98, 99].…”

Section: Clinical Evidence Of Gh Excess In Humansmentioning

confidence: 99%

“…GH exerts its effects either directly or indirectly [2, 21, 22]. Most of the indirect effects are mediated by induction of IGF-1 expression in the liver and in peripheral tissues [23-27].…”

Section: Introductionmentioning

confidence: 99%

The GH/IGF-1 Axis and Heart Failure

Castellano¹,

Affuso²,

Conza³

et al. 2009

CCR

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The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis regulates cardiac growth, stimulates myocardial contractility and influences the vascular system. The GH/IGF-1 axis controls intrinsic cardiac contractility by enhancing the intracellular calcium availability and regulating expression of contractile proteins; stimulates cardiac growth, by increasing protein synthesis; modifies systemic vascular resistance, by activating the nitric oxide system and regulating non-endothelial-dependent actions. The relationship between the GH/IGF-1 axis and the cardiovascular system has been extensively demonstrated in numerous experimental studies and confirmed by the cardiac derangements secondary to both GH excess and deficiency. Several years ago, a clinical non-blinded study showed, in seven patients with idiopathic dilated cardiomyopathy and chronic heart failure (CHF), a significant improvement in cardiac function and structure after three months of treatment with recombinant GH plus standard therapy for heart failure. More recent studies, including a small double-blind placebo-controlled study on GH effects on exercise tolerance and cardiopulmonary performance, have shown that GH benefits patients with CHF secondary to both ischemic and idiopathic dilated cardiomyopathy. However, conflicting results emerge from other placebo-controlled trials. These discordant findings may be explained by the degree of CHF-associated GH resistance. In conclusion, we believe that more clinical and experimental studies are necessary to exactly understand the mechanisms that determine the variable sensitivity to GH and its positive effects in the failing heart.

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Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy

Cited by 12 publications

References 42 publications

Cell signaling in trophoblast-uterine communication

Cell signaling in trophoblast-uterine communication

Diverse functions of HBEGF during pregnancy

The GH/IGF-1 Axis and Heart Failure

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