Diverse functions of HBEGF during pregnancy

Jessmon, Philip; Leach, Richard E.; Armant, D. Randall

doi:10.1002/mrd.21066

Cited by 65 publications

(62 citation statements)

References 115 publications

(151 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HBEGF is a secreted member of the epidermal growth factor (EGF) family of growth factors, and is well known in placental physiology as a factor that promotes trophoblast invasiveness, and also prevents hypoxemic damage (Imudia et al, 2008;Jessmon et al, 2010Jessmon et al, , 2009Leach et al, 2008;Lim and Dey, 2009). To our knowledge, the regulation of its expression by modulated mRNA decay has not been evaluated previously.…”

Section: Discussionmentioning

confidence: 99%

Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism

et al. 2016

View full text Add to dashboard Cite

The ZFP36L3 protein is a rodent-specific, placenta-and yolk sacspecific member of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins. These proteins bind to AU-rich elements in target mRNAs, and promote their deadenylation and decay. We addressed the hypotheses that the absence of ZFP36L3 would result in the accumulation of target transcripts in placenta and/or yolk sac, and that some of these would be important for female reproductive physiology and overall fecundity. Mice deficient in ZFP36L3 exhibited decreased neonatal survival rates, but no apparent morphological changes in the placenta or surviving offspring. We found Zfp36l3 to be paternally imprinted, with profound parent-of-origin effects on gene expression. The protein was highly expressed in the syncytiotrophoblast cells of the labyrinth layer of the placenta, and the epithelial cells of the yolk sac. RNA-Seq of placental mRNA from Zfp36l3 knockout (KO) mice revealed many significantly upregulated transcripts, whereas there were few changes in KO yolk sacs. Many of the upregulated placental transcripts exhibited decreased decay rates in differentiated trophoblast stem cells derived from KO blastocysts. Several dozen transcripts were deemed high probability targets of ZFP36L3; these include proteins known to be involved in trophoblast and placenta physiology. Type 1 transferrin receptor mRNA was unexpectedly decreased in KO placentas, despite an increase in its stability in KO stem cells. This receptor is crucial for placental iron uptake, and its decrease was accompanied by decreased iron stores in the KO fetus, suggesting that this intrauterine deficiency might have deleterious consequences in later life.

show abstract

Section: Discussionmentioning

confidence: 99%

Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism

et al. 2016

View full text Add to dashboard Cite

show abstract

“…HB-EGF regulates decidualization by upregulating the cyclin D3 mediated polyploidization of uterine stromal cells (Jessmon et al, 2009). Progesterone maintains EGFR expression during pregnancy and promotes growth of the decidua.…”

Section: Regulation Of Endometrial Receptivity and Trophoblast Attachmentioning

confidence: 99%

The role of progesterone in implantation and trophoblast invasion

Halász

Szekeres-Barthó

2013

Journal of Reproductive Immunology

103

View full text Add to dashboard Cite

Publication informationJournal of Reproductive Immunology, 97 (1): 43-50Publisher Elsevier Item record/more information http://hdl.handle.net/10197/5006 Publisher's statementThis is the author's version of a work that was accepted for publication in Journal of Reproductive Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Reproductive Immunology (97, 1, (2013) AbstractBy its genomic and non-genomic actions progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration.The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in rapid non-genomic actions of progesterone.Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualization and implantation.Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of estrogen, and by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.

show abstract

“…Although its involvement in oocyte maturation and fertilization has not yet been shown, implantation of mammalian early embryos involves the actions of ErbB4 and its cognate ligand heparin-binding EGF-like growth factor (HB-EGF) (Chobotova et al 2002). In this system, metalloproteinase-dependent extracellular shedding of HB-EGF is required for survival of trophoblasts at low oxygen conditions (Armant et al 2006;Jessmon et al 2009), one of pro-apoptotic pressures in the embryogenic microenvironment at early stages of pregnancy.…”

Section: Erbb4/her4mentioning

confidence: 99%