Changes in the etiology of viral lower respiratory tract infections in hospitalized children in Wenzhou, China: 2008‐2017

Wen, Shunhang; Yu, Mei; Zheng, Guifeng; Lv, Fangfang; Chen, Xiaofang; Lin, Li; Li, Changchong; Zhang, Hailin

doi:10.1002/jmv.25660

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…A similar pattern was also observed in our study, despite the retrospective data collection. However, the seasonal epidemiology might show some differences between temperate and tropical/subtropical climates (20). Generally, in our study, the clinical and radiologic characteristics of patients with the three types of PMV-p were similar.…”

Section: Discussionsupporting

confidence: 55%

The Clinical Characteristics and Outcomes of Adult Patients With Pneumonia Related to Three Paramyxoviruses

Chen

Han

et al. 2021

Front. Med.

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Background: Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and human parainfluenza virus (hPIV) are paramyxoviruses (PMVs) that are important etiologies of community-acquired pneumonia. However, current knowledge about the clinical features and outcomes of PMV-related pneumonia (PMV-p) is limited. We aimed to investigate the clinical characteristics and disease severity in immunocompetent adults hospitalized with hMPV-related pneumonia (hMPV-p), hPIV-related pneumonia (hPIV-p), or RSV-related pneumonia (RSV-p).Methods: We retrospectively recruited 488 patients with PMV-p (153 with RSV-p, 137 with hMPV-p, and 198 with hPIV-p) from five teaching hospitals in China during 2011–2019. Univariate and multivariate analyses were performed to identify predictors to distinguish hMPV-p/hPIV-p from RSV-p and evaluate the effects of virus types on the clinical outcomes.Results: Compared with RSV-p, sputum production [odds ratio (OR) 5.029, 95% confidence interval (CI) 2.452–10.312, P < 0.001] was positively associated with hMPV-p, while solid malignant tumor (OR 0.346, 95% CI 0.126–0.945, P = 0.038), nasal congestion (OR 0.102, 95% CI 0.041–0.251, P < 0.001), and respiratory rate ≥ 30 breaths/min (OR 0.296, 95% CI 0.136–0.640, P = 0.002) were negatively related to hMPV-p. Sputum production (OR 13.418, 95% CI 6.769–26.598, P < 0.001) was positively associated with hPIV-p, while nasal congestion (OR 0.194, 95% CI 0.098–0.387, P < 0.001), dyspnea (OR 0.469, 95% CI 0.272–0.809, P < 0.001), and respiratory rate ≥30 breaths/min (OR 0.090, 95% CI 0.032–0.257, P < 0.001) on admission were negatively related to hPIV-p. After adjustment for confounders, multivariate logistic regression analysis suggested that hMPV-p (OR 0.355, 95% CI 0.135–0.932, P = 0.035) and hPIV-p (OR 0.311, 95% CI 0.121–0.784, P = 0.013) were associated with decreased 30-day mortality compared with RSV-p. RSV infection (OR 4.183, 95% CI 1.709–10.236, P = 0.002) was identified as an independent predictor of 30-day mortality in patients with PMV-p.Conclusion: RSV-p caused more severe disease than hMPV-p and hPIV-p. Although some clinical features are helpful for distinguishing the diseases, etiologic diagnosis is critical in the management of the PMV-p.

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Section: Discussionsupporting

confidence: 55%

The Clinical Characteristics and Outcomes of Adult Patients With Pneumonia Related to Three Paramyxoviruses

Chen

Han

et al. 2021

Front. Med.

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“…For instance, the respiratory syncytial virus exhibits notable seasonal distributions, namely, beginning in early autumn, peaking at the end of November or in early December, and gradually decreasing in spring. However, adenovirus, influenza, and human parainfluenza virus were more frequently detected in the spring and summer months, between March and August [ 25 , 26 ]. A study on the admission of children with respiratory diseases in Beijing showed that the most common diagnosis (86.11%) in the adenovirus-positive cases was pneumonia, which was accompanied by common signs and symptoms of fever and cough [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the effects of meteorological factors on daily children's respiratory disease hospitalizations: A retrospective study

Guo

Wang

et al. 2020

Heliyon

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Respiratory disease symptoms in children are aggravated by frequent changes in meteorological conditions. The net effective temperature (NET) integrates temperature, relative humidity, and wind speed as a cooling indicator. This study aims to assess the effect of daily changes in meteorological factors and corresponding NET data on children's hospitalizations for different ages, genders and subtypes of respiratory infections in Baotou, China. Distributed lag non-linear models were constructed to simultaneously assess the exposure–response associations between daily admission counts of children with respiratory diseases and daily NET and other meteorological factors, as well as their lag dependencies. As air pollution significantly affects the respiratory tract, it was considered as confounding factor. In general, the cumulative meteorological factors had greater effects on lower respiratory tract infections than upper respiratory tract infections (RR: temperature [5.21 vs. 2.33], wind speed [4.89 vs. 3.12], and humidity [1.77 vs. 0.97]). The effects of cumulative meteorological factors on female children were greater than those on male children (RR: temperature [2.14 vs. 1.82], wind speed [5.46 vs. 1.90], and humidity [1.60 vs. 1.55]). Temperature and wind speed showed an influence on 4–7-year-old children, but these factors had no influence on other age groups; humidity only showed an influence on the 0–3-year-old group. The NET value had a large effect on lower respiratory infections, in the 4–7-year-old group and female children. In conclusion, a complex non-linear relationship exists between climate variability and children's respiratory diseases. The results of the study can be used to support the development of important meteorological information tools for early warnings of respiratory disease events in children. Concurrently, the NET values can be used for comprehensive assessments of climate change in the future, which will help the government and health authorities better minimize the impacts of children's respiratory diseases.

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“…Moreover, no delay was observed between respiratory syncytial virus detection in communities and hospitals. However, adenovirus, influenza, and human parainfluenza virus were more frequently detected in the spring and summer months, between March and August [23,24]. A study on admission of children with respiratory diseases in Beijing showed that the most common diagnosis (86.11%) in the adenovirus-positive cases was pneumonia, which was accompanied by the common signs and symptoms of fever and cough [12].…”

Section: Discussionmentioning

confidence: 99%

Assessing the effect of meteorological factors on daily children’s respiratory disease hospitalizations: a retrospective study

Guo

Wang

et al. 2020

Preprint

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Background Some previous studies have examined the effects of temperature, humidity, wind speed and atmospheric pressure on children morbidity, but few studies have evaluated health effects of combined effect of various meteorological factors. The purpose of this study was to assess the effect of daily changes in meteorological factors and their comprehensive effects on children’s respiratory disease hospitalizations for different ages, genders and subtypes in Baotou, China. Methods Generalized additive models and distributed lag non-linear models were constructed to simultaneously assess the exposure–response associations between daily admission counts of children with respiratory diseases and daily net effective temperature and other meteorological factors as well as their lag dependencies. Results In general, the cumulative meteorological factors had greater effects on lower respiratory tract infections than upper respiratory tract infections (RR: temperature [4.2 vs. 2.7]; wind speed [3.1 vs. 2.5]; humidity [1.8 vs. 1.3]). The effects on children over 3 years old were greater than those on children aged 0–3 years (OR: temperature [4.4 vs. 1.3]; wind speed [4.4 vs. 1.5]), while the effects on female children were greater than those on male children (OR: temperature [2.6 vs. 1.8]; wind speed [3.3 vs. 1.6]). However, some differences were observed between groups with regard to the effect of humidity. Hence, the net effective temperature was calculated using comprehensive meteorological factors, and the influence range value and peak value of each group were determined. Conclusions The influence of meteorological factors on children’s respiratory disease hospitalizations shows different characteristics in different subgroups. Hence, the net effective temperature was calculated using the comprehensive meteorological factors, and the influence range and peak value of each group were determined so as to recommend the corresponding measures accordingly.

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Changes in the etiology of viral lower respiratory tract infections in hospitalized children in Wenzhou, China: 2008‐2017

Cited by 13 publications

References 26 publications

The Clinical Characteristics and Outcomes of Adult Patients With Pneumonia Related to Three Paramyxoviruses

The Clinical Characteristics and Outcomes of Adult Patients With Pneumonia Related to Three Paramyxoviruses

Assessing the effects of meteorological factors on daily children's respiratory disease hospitalizations: A retrospective study

Assessing the effect of meteorological factors on daily children’s respiratory disease hospitalizations: a retrospective study

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