Changes in the distribution of hepatitis C virus (HCV) genotypes over time in Spain according to HIV serostatus: Implications for HCV therapy in HCV/HIV-coinfected patients

Ramos, Belén; Núñez, Marina; Toro, Carlos; Sheldon, Julie; García-Samaniego, Javier; Ríos, Pilar; Soriano, Vincent

doi:10.1016/j.jinf.2006.02.006

Cited by 30 publications

(27 citation statements)

References 30 publications

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“…However, no significant difference was found in Pakistan as the distributions of HCV genotypes were similar in both male and female patients (38,39). Unlike a recent study (40), we were able to find an association between HCV genotypes/subtypes and age, where a predominant prevalence of HCV genotypes 3 and 6 was seen in younger age patients. However, it should be noted that age at HCV infection, although found to be associated with the changes in HCV genotypes' distribution over time in univariable analysis, its significance did not persist in multivariable analysis.…”

Section: Discussioncontrasting

confidence: 99%

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Zhang

Fan

Wang³

et al. 2012

Hepat Mon

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Background:The changing pattern of hepatitis C virus (HCV) infection could have a significant impact on future medical prevention practices and therapies. Objectives: The purpose of this study was to describe the changing pattern of HCV infection in southwest China using clinical epidemiology, and to assess the association between the genotypes distribution and certain potential risk factors. Patients and Methods: A retrospective analysis which included 1208 subjects with chronic HCV registered at the Southwest Hospital (Chongqing, Southwest China) was performed. The information was reviewed and the data collected from clinical records and short telephone interviews when necessary. HCV genotypes were determined by nucleotide sequencing of the CE1 regions followed by phylogenic analysis with the published HCV genotype. HCV genotype distribution was analyzed according to the patients' age, gender, risk exposure, and the initial risk exposure. Results: Among the 1 208 patients, the HCV subtype 1b was the most prevalent (32.9%), followed by subtype 3b (18.9%), 6a (18.0%), 3a (12.8%) and 2a (10.4%), while subtypes 1a and 6k accounted for cases of HCV infection in only 9 and 3 cases respectively. Individuals older than 40 years were mainly infected with subtypes 1b and 2a, whereas younger patients were predominantly infected with genotypes 3 and 6. Subtypes 1b and 2a were observed more frequently among 44.4% and 16.0% patients respectively, with a history of invasive operations. Subtypes 3b and 6a constituted the majority of HCV infections among intravenous drug users (IDUs) (28.7% and 34.9%, respectively). A significant difference (P < 0.001) was observed between the HCV genotype distributions, according to the potential route of infection. Conclusion: In southwest China, the most common remaining subtype is the 1b genotype, but this has declined significantly among young patients. This is followed by subtype 3b and 6a which has increased significantly, especially among young patients. The distribution of such genotypes was also variable according to gender and age. The changing pattern of HCV infection was associated with changes in the modes of HCV acquisition, which raises an alarm signal concerning the major steps that need to be taken in order to reduce such infections in southwest China.

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Section: Discussioncontrasting

confidence: 99%

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Zhang

Fan

Wang³

et al. 2012

Hepat Mon

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“…Genotype 3 was found in 43 cases (25.5%) and genotype 2 in four cases (2.3%)( Table 1). Similar results have been reported by other studies that evaluated the same parameters among coinfected patients 21,22,24 . Our findings are also consistent with those described in a study evaluating HCV genotypic distribution among mono-infected patients in Brazil 2,3,4,16 .…”

Section: Discussionsupporting

confidence: 91%

Clinical and histological characteristics of HIV and hepatitis C virus-co-infected patients in Brazil: a case series study

Mendes-Corrêa

Widman

Brussi

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYHepatitis C virus (HCV) is an important factor contributing to morbidity and mortality in patients co-infected with HIV and HCV. In addition, liver biopsy is an important tool in the clinical management of these patients. Although liver biopsy is controversial, it is recommended for all patients. Data regarding the clinical and histological characteristics of these patients are scarce not only in Brazil but in Latin America as a whole. With the goal of better understanding these characteristics and the benefit of liver biopsy indications in this disease setting, data collected from 234 patients followed from 1996 to 2004 at Casa da AIDS, São Paulo, were analyzed. The following variables were extracted from the patients' medical files at the time of liver biopsy: sex, age, hepatitis C infection risk factors, hepatitis C infection duration, ALT levels, CD4 + T cell counts, history of alcohol abuse, history of antiretroviral therapy, HCV genotype, and liver histological alterations. Conclusions: 1 -Hepatitis C virus 1 and 3 were the most frequently identified genotypes and were diagnosed in 72% and 25.5% of cases respectively; 2 -Structural liver alterations were found to be mild or absent in 48.2% (113/234) of the analyzed patients; 3 -Fifty-three patients (23%) had normal ALT levels and 4 -Significant liver architectural changes (F2-F3) were evident in 22.5% of the patients with normal ALT levels.

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“…In another study it was reported that HCV4 was significantly more frequent among HIV-positive than among HCVmonoinfected patients, 13% versus 9.1% [Ramos et al, 2007], although the difference can be explained mainly by the route of infection rather than by the HIV status [Ramos et al, 2007].…”

Section: Discussionmentioning

confidence: 92%

High prevalence of genotype 4 among hepatitis C virus‐infected intravenous drug users in North‐Eastern Poland

Chlabicz¹,

Flisiak²,

Kowalczuk³

et al. 2008

Journal of Medical Virology

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The aim of this study was to describe the distribution of hepatitis C genotypes among intravenous drug users in north-eastern Poland. The study group included intravenous drug users recruited at a drug treatment center and a clinic for HIV-infected patients. HCV infection was confirmed by qualitative nested RT-PCR to test for the presence of HCV RNA. Genotypes were determined by 5'UTR sequencing and comparing the results with known genotype sequences. Among 111 HCV-infected and HCV-RNA-positive intravenous drug users, the most prevalent genotypes were 1 (38.7%), 3 (37.8%), and 4 (23.4%). Most infections with genotype 4 (88.5%) were found among HCV-HIV-coinfected drug users. The study demonstrated a high prevalence of genotype 4 (23.4%) among HCV-infected Polish drug users.

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Changes in the distribution of hepatitis C virus (HCV) genotypes over time in Spain according to HIV serostatus: Implications for HCV therapy in HCV/HIV-coinfected patients

Cited by 30 publications

References 30 publications

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Clinical and histological characteristics of HIV and hepatitis C virus-co-infected patients in Brazil: a case series study

High prevalence of genotype 4 among hepatitis C virus‐infected intravenous drug users in North‐Eastern Poland

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