Changes in the distribution of laminin alpha1 chain in psoriatic skin: immunohistochemical study using confocal laser scanning microscopy

Vaccaro, Mario; Magaudda, Ludovico; Cutroneo, Giuseppina; Trimarchi, Fabio; Barbuzza, Olga; Guarneri, Fabrizio; Guarneri, Biagio

doi:10.1046/j.1365-2133.2002.04637.x

Cited by 34 publications

(45 citation statements)

References 22 publications

(38 reference statements)

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“…In psoriatic skin, laminin expression is disrupted in the basement membrane and reactive clusters of keratinocytes can be observed, mostly located under the stratum corneum [28]. In substitutes made with psoriatic keratinocytes (both combinations), the expression of laminin is disrupted in some regions of the basement membrane while such disruption is not observed for the psoriatic fibroblast/healthy keratinocyte combinations.…”

Section: Discussionmentioning

confidence: 97%

Development of an in vitro psoriatic skin model by tissue engineering

Jean

Lapointe

Soucy

et al. 2009

Journal of Dermatological Science

115

114

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Section: Discussionmentioning

confidence: 97%

Development of an in vitro psoriatic skin model by tissue engineering

Jean

Lapointe

Soucy

et al. 2009

Journal of Dermatological Science

115

114

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“…[23][24][25][26][27][28] A topical administration to stem cells at the site of the wound injury would allow a more direct stimulatory response and would work only if an appropriate interference with site-specific mechanistic responses occurred. The elucidation of such mechanisms and the development of a therapeutic potential are the scope and success of this study.…”

Section: Introductionmentioning

confidence: 99%

Interactive Role of Trauma Cytokines and Erythropoietin and Their Therapeutic Potential for Acute and Chronic Wounds

Bader¹,

Lorenz²,

Richter³

et al. 2011

Rejuvenation Research

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If controllable, stem cell activation following injury has the therapeutic potential for supporting regeneration in acute or chronic wounds. Human dermally-derived stem cells (FmSCs) were exposed to the cytokines interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) in the presence of erythropoietin (EPO). Cells were cultured under ischemic conditions and phenotypically characterized using flow cytometry. Topical EPO application was performed in three independent clinical wound healing attempts. The FmSCs expressed the receptor for EPO. EPO had a strong inhibitory effect on FmSC growth in the absence of IL-6 and TNF-α. With IL-6, the EPO effects were reversed to that of growth stimulation. TNF-α had the strongest stimulatory effect. In contrast, IL-1β had an inhibitory effect. Topically applied EPO considerably enhanced wound healing and improved wound conditions of acute and chronic wounds. Site specificity of stem cell activation is mediated by IL-6 and TNF-α. In trauma, EPO ceases its inhibitory role and reverts to a clinically relevant boosting function. EPO may be an important therapeutic tool for the topical treatment of acute and chronic wounds.

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“…19 Previous immunohistochemical study showed that the expression of the a1 chain in the basal lamina of active psoriasis vulgaris is discontinuous or normal, the expression of the a2 chain is weak and irregular in the lesions, while the expression of the b1 and c1 laminin chains and collagen IV is normal. 20,21 Nevertheless, one can imagine that qualitative or quantitative change of laminin c1 expression, which is unique in psoriatic skin but could not be detected by previous immunohistochemical studies, may be involved in the production of anti-laminin c1 autoantibodies in psoriatic patients, and followed by the development of anti-laminin c1 pemphigoid (Fig. 5).…”

Section: Laminin and Psoriasismentioning

confidence: 99%

From anti‐p200 pemphigoid to anti‐laminin γ1 pemphigoid

Dainichi

Koga

Tsuji

et al. 2010

The Journal of Dermatology

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Anti-laminin c1 pemphigoid is an autoimmune subepidermal bullous disease first described in 1996, and has been distinct from previously known subepidermal blistering diseases, such as bullous pemphigoid and epidermolysis bullosa acquisita. Circulating autoantibodies of the patients do not react to any known autoantigen of the skin, but react to a 200-kDa molecule (p200) from dermal extracts. The identity of p200 was unmasked as laminin c1, an extracellular matrix glycoprotein composing several forms of laminin heterotrimers. We renamed this disease from the previously used anti-p200 pemphigoid to anti-laminin c1 pemphigoid, a new entity of an autoimmune bullous disease. In this decade, we have experienced over 70 cases of this disease. Although the number of the cases of anti-laminin c1 pemphigoid is half as many as the number of definitely diagnosed cases of epidermolysis bullosa acquisita in the same duration, a considerable number of the cases could be clinically misdiagnosed as epidermolysis bullosa acquisita. Unveiling the pathogenicity and development of a useful diagnostic method is necessary for appropriate management of this new disease.

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Changes in the distribution of laminin alpha1 chain in psoriatic skin: immunohistochemical study using confocal laser scanning microscopy

Abstract: The present study defines the location of the laminin alpha1 chain in involved and uninvolved psoriatic skin and suggests a possible role of the alteration of this chain, together with T-cell lymphokines and fibronectin, in the dysregulation of cell morphological processes.

Cited by 34 publications

References 22 publications

Development of an in vitro psoriatic skin model by tissue engineering

Development of an in vitro psoriatic skin model by tissue engineering

Interactive Role of Trauma Cytokines and Erythropoietin and Their Therapeutic Potential for Acute and Chronic Wounds

From anti‐p200 pemphigoid to anti‐laminin γ1 pemphigoid

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