Changes in the Concentrations of Mediators of Inflammation and Oxidative Stress in Exhaled Breath Condensate During Liver Transplantation and Their Relations With Postoperative ARDS

Liu, Dezhao; Luo, Gangjian; Luo, Chenfang; Wang, Tao; Sun, Guoliang; Hei, Ziqing

doi:10.4187/respcare.03311

Cited by 19 publications

(12 citation statements)

References 32 publications

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“…Our findings are similar to those reported in patients with Acute Respiratory Distress Syndrome (ARDS) and to the results found in the bronchial washing and BAL of asthmatic patients , in whom airway inflammation has been related to an increase in GSSG levels. Mak et al .…”

Section: Discussionsupporting

confidence: 91%

Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Moreno‐Solís

Torre-Aguilar

Torres-Borrego

et al. 2016

Clinical Respiratory J

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Section: Discussionsupporting

confidence: 91%

Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Moreno‐Solís

Torre-Aguilar

Torres-Borrego

et al. 2016

Clinical Respiratory J

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“…Postoperative ARDS was diagnosed according to the 2012 Berlin definition of ARDS, specifically PaO 2 /FiO 2 < 300 and the acute onset of bilateral infiltrates on the chest radiograph during postoperative day 1 (POD1) to POD3, which were not fully explained by cardiac failure [22–24]. ARDS was based on degree of hypoxemia: mild (200 mm Hg < PaO2/FIO2 ≤ 300 mm Hg), moderate (100 mm Hg < PaO2/FIO2 ≤ 200 mm Hg), and severe (PaO2/FIO2 ≤ 100 mm Hg).…”

Section: Methodsmentioning

confidence: 99%

Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16

Cheng

Hung

et al. 2019

BioMed Research International

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Background. Acute respiratory distress syndrome (ARDS) after living-donor liver transplantation (LDLT) is not uncommon, but it lacks the biomarkers for early detection. Club cell protein 16 (CC16), high-motility group box 1 protein (HMGB1), interleukin-1β (IL-1β), and IL-10 have been reported as relevant to the development of ARDS. However, they have not been investigated during LDLT. Methods. Seventy-three consecutive recipients undergoing LDLT were enrolled and received the same perioperative care plan. Perioperative serum CC16, HMGB1, IL-1β, and IL-10 levels were measured at the pretransplant state, 30 minutes after reperfusion, postoperative day 1 (POD1), and POD3. ARDS was diagnosed according to the 2012 Berlin definition. Results. Of the 73 recipients, 13 developed ARDS with significantly longer durations of mechanical ventilation and intensive care unit stay. Serum CC16 levels on POD1 increased significantly from the pretransplant state in the ARDS group but not in the non-ARDS group. Pretransplant serum CC16 levels were also higher in the ARDS group. The area under the receiver operating characteristic curves for POD1 serum CC16 levels used to discriminate ARDS was 0.803 (95% confidence interval: 0.679 to 0.895; p < 0.001). By comparison, HMGB1, IL-1β, and IL-10 were not associated with ARDS after LDLT. Conclusion. The higher pretransplant serum CC16 level and its increased level on POD1 were associated with the development of early ARDS after LDLT. This trial is registered with NCT01936545, 27 August 2013.

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“…Biomarker levels in the exhaled breath condensate (EBC) can reflect pulmonary disease status. We used special glass equipment, which was devised by our team and has been described elsewhere [ 20 ], to collect EBC non-invasively for approximately 30 min at T1 (before surgery) and T2 (at the end of operation). Venous blood samples were collected at T1, T2, T3 (12 h after operation), and T4 (24 h after operation).…”

Section: Methodsmentioning

confidence: 99%

N-Acetylcysteine inhalation improves pulmonary function in patients received liver transplantation

Wei

Chen

et al. 2018

Bioscience Reports

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Postoperative pulmonary complications (PPCs) following orthotopic liver transplantation (OLT) are associated with high morbidity and mortality rates. The effect of N-acetylcysteine (NAC) inhalation on the incidence of PPCs and the outcomes of patients undergoing OLT is unknown. This prospective randomized controlled clinical trial was conducted to investigate the effect of NAC inhalation during OLT on PPCs. Sixty patients were randomly assigned to the NAC group (n = 30) or the control group (n = 30) to receive inhaled NAC or sterilized water, respectively, for 30 min before surgery and 3 h after reperfusion. The incidence of early PPCs and outcomes including survival rate were assessed. Biomarkers including tumor necrosis factor (TNF)-α, interleukin (IL)-8, Clara cell secretory protein (CC16), intercellular adhesion molecule (ICAM)-1, and superoxide dismutase (SOD) were measured in exhaled breath condensate (EBC) at T1 (before surgery) and T2 (at the end of operation) as well as in serum at T1, T2, T3 (12 h after operation), and T4 (24 h after operation). A total of 42 patients (20 in the NAC group and 22 in the control group) were enrolled in the final analysis. Atomization inhaled NAC significantly reduced the incidence of PPCs after OLT. The levels of TNF-α, IL-8, CC16, and ICAM-1 in EBC were significantly lower, and SOD activity was higher, at T2 in the NAC group; similar data were found in serum at T2, T3, and T4. In summary, perioperative NAC inhalation may reduce the incidence of PPCs and improve patient outcomes after OLT.

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Changes in the Concentrations of Mediators of Inflammation and Oxidative Stress in Exhaled Breath Condensate During Liver Transplantation and Their Relations With Postoperative ARDS

Cited by 19 publications

References 32 publications

Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis

Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16

N-Acetylcysteine inhalation improves pulmonary function in patients received liver transplantation

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