Changes in the colonic temperature and metabolism during immobilization stress in repetitively immobilized or cold-acclimated rats.

Abstract

Effect of immobilization stress on the rat colonic temperature and metabolism was studied in a warm environment of 25°C. Immobilization for 3 hr caused hyperthermia accompanied by increased oxygen consumption (J'02) in the warm controls. The hyperthermic effect of immobilization was accelerated after 1 week repetition of daily immobilization and it was lessened after 2 to 4 week repetition of daily immobilization. The magnitude of Vo2 increase was the same throughout the experimental period of 4 weeks during the immobilization. Hypothermia was never observed during immobilization. Immobilizationinduced hyperthermia was significantly potentiated in the cold-acclimated rats, while V0, increase did not differ between cold-acclimated rats and warm controls. These results suggest that immobilization stress causes the changes in body temperature through thermogenic and heat-loss mechanisms.

Effects of cold and immobilization stress on noradrenaline turnover in brown adipose tissue of rat.

“…The body weights at the time of NA determination were 293 + 3.1, 253 + 2.9 g (p vs. NSWC <0.01), and 225+2.5 g (p vs. NSWC <0.01), respectively. As previously reported (KUROSHIMA et al, 1984;KUROSHIMA and YAHATA, 1985), the body growth was suppressed in CA and ST.…”

“…This finding suggests that the activated BAT function is closely associated with an enhanced thermogenesis observed during immobilization stress (KUROSHIMA and YAHATA, 1985). It also suggests that cross adaptation between cold and stress previously reported (KUROSHIMA et al, 1984) is mediated, at least in part, through an enhanced sympathetic activity in BAT.…”

Stress-induced attenuation of the hypercapnic ventilatory response in awake rats

“…In both series of experiments, V CO 2 and Pa CO 2 values were elevated in stressed rats vs. control animals. Although the increase in V CO 2 is in accordance with other reports suggesting that restraint stress increases metabolism (23,33), the lack of significant differences in resting minute ventilation between groups is consistent with a potential reduction in the resting hypercapnic ventilatory drive in stressed rats. These results are in agreement with plethysmographic measurements showing that previous exposure to a single immobilization stress session is sufficient to attenuate the ventilatory response to moderate hypercapnia in awake rats.…”

Repeated Immobilization Stress Increases Uncoupling Protein 1 Expression and Activity in Wistar Rats.

“…Acute immobilization induces hyperthermia in rats [43][44][45], which can be inhibited by BAT sympathectomy [46]. In the present experiment, core temperature increased after 3 h of acute immobilization, suggesting that BAT UCP1 activation may be directly linked to an increase of body temperature.…”