Changes in the clinical characteristics, treatment options, and therapy outcomes in patients with phyllodes tumor of the breast during 55 years of experience

Mituś, Jerzy; Blecharz, Paweł; Reinfuss, Marian; Kulpa, J; Skotnicki, Piotr; Wysocki, Wojciech M.

doi:10.12659/msm.889687

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…Breast cancer is one of the most common malignant tumors in women. [ 16 ] During the past decade, there has been increasing scientific interest in understanding the complex relationship between breast cancer and renin-angiotensin system (RAS). [ 17 18 ] The RAS plays an important role in blood pressure and cardiovascular homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Imminent angiotensin-converting enzyme inhibitor from microbial source for cancer therapy

Ebrahimi

Alizadeh

et al. 2017

Int J Prev Med

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Background:Drugs targeting Angiotensin I-converting enzyme (ACE) have been used broadly in cancer chemotherapy. The recent past coupled with our results demonstrates the effective use of ACE inhibitors (ACEi) as anticancer agents, and they are potentially relevant in deriving new inhibitors.Methods:Bacterial strains were isolated from cow milk collected in Coimbatore, Tamil Nadu, India and plated on nutrient agar medium. The identity of the strain was ascertained by 16s rRNA gene sequencing method and was submitted to the NCBI GenBank nucleotide database. Various substrates were screened for ACEi production by the fermentation with the isolated strain. ACEi was purified by sequential steps of ethanol precipitation, ion exchange column chromatography and gel filtration column chromatography. The apparent molecular mass was determined by SDS-PAGE. The anticancer property was analyzed by studying the cytotoxicity effects of ACEi using Breast cancer MCF-7 cell linesResults:The isolate coded as BUCTL09 was selected and identified as Micrococcus luteus. Among the seven substrates, only beef extract fermented broth showed an inhibition of 79% and was reported as the best substrate. The peptide was purified and molecular mass was determined. The IC50 value of peptide was found to be 59.5 μg/ml. The purified peptide has demonstrated to induce apoptosis of cancer cell.Conclusions:The results of this study revealed that Peptide has been determined as an active compound that inhibited the activity of ACE. These properties indicate the possibilities of the use of purified protein as a potent anticancer agent.

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Section: Discussionmentioning

confidence: 99%

Imminent angiotensin-converting enzyme inhibitor from microbial source for cancer therapy

Ebrahimi

Alizadeh

et al. 2017

Int J Prev Med

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“…While the epithelial component of most PT contains estrogen and progesterone receptors, hormone therapy did not demonstrate any significant efficacy in the treatment of DM [ 4 , 6 , 8 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast

et al. 2015

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BackgroundHere, the treatment methods and results of patients with phyllodes tumor of the breast (PT) with distant metastases at a single institution are presented.MethodsA retrospective analysis was performed on a group of 295 patients with PT treated from 1952 to 2010.ResultsDistant metastases developed in 37 (12.5 %) patients; 3/160 (1.9 %) patients had benign PT, 6/36 (16.7 %) were considered borderline, and 28/99 (28.3 %) had malignant PT. Most frequently, the metastases were located in the lungs; 28 (75.7 %), bone 7 (18.9 %), brain 4 (10.8 %), and liver 2 (5.4 %). Metastases occurred on overage 21 months (2–57) after surgery. Patients with lung metastases were generally treated with monochemotherapy or polychemotherapy. In one patient Testosterone and in two patients resection of metastases combined with Doxorubicin were used. Patients with bones or brain metastases were treated with palliative radiotherapy only or combined with Doxorubicin. The mean survival (MS) from diagnosis of distant metastases (DM) was 7 months (2–17). The longest mean survival in patients with bones metastases was 11.8 months, the worst survival was for patients with brain metastases—2.8 months. Hormone therapy appeared to have low efficacy (MS: 2 months) as well as monochemotherapy (MS: 3–5 months). Improved MS was obtained using Doxorubicin (7 months) and Doxorubicin with Cisplatin, Cyclophosphamide, or Ifosfamide (9 months).ConclusionThe prognosis of patients with DM from PT is poor. The role of surgery and irradiation of such patients is very limited. There appears to be no role for the use of hormone therapy. This study showed that polychemotherapy with Doxorubicin and Ifosfamide suggest that it might be more effective than once thought.

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“…It is also worth mentioning that malignant PT tumors are becoming less frequent, with smaller tumor size at diagnosis and a younger patient age. These results were published recently by Mitus et al, after reviewing the data of 280 women from 1952 to 2007, who were treated surgically for PT at the Maria Sklodowska-Curie Memorial Institute of Oncology Cancer Center in Cracow, Poland [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is even less common in benign PT. Treatment options varies based on tumor size, age at diagnosis, and histology, with breast-conserving therapy being the preferred treatment in patients who were younger at diagnosis and in those with smaller tumors [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Invasive Ductal Carcinoma within a Benign Phyllodes Tumor

et al. 2017

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Patient: Female, 70Final Diagnosis: Benign phyllodes tumorSymptoms: FatigueMedication: —Clinical Procedure: Right breast lumpectomySpecialty: SurgeryObjective:Rare diseaseBackground:Phyllodes tumor (PT) is a rare neoplasm of the breast. Concomitant PT with invasive ductal carcinoma (IDC) is an even rarer occurrence. When ductal carcinoma in situ (DCIS) or IDC are detected within the specimen, the management changes from wide local excision to further staging work-up, including sentinel node biopsy and radiation.Case Report:We report the case of a 70-year-old presented with right breast mass whose pathology showed benign PT with concomitant IDC and DCIS. The patient elected for a wide excision of the mass with sentinel lymph node biopsy, which did not show any involvement. The patient was started on appropriate therapy. She is currently doing well.Conclusions:This case highlights the importance of wide local excision for PT as well as prudent histologic examination to rule out other malignant components, as the presence of IDC distinctly changes management.

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Changes in the clinical characteristics, treatment options, and therapy outcomes in patients with phyllodes tumor of the breast during 55 years of experience

Cited by 18 publications

References 25 publications

Imminent angiotensin-converting enzyme inhibitor from microbial source for cancer therapy

Imminent angiotensin-converting enzyme inhibitor from microbial source for cancer therapy

Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast

Invasive Ductal Carcinoma within a Benign Phyllodes Tumor

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